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- W2060026013 abstract "Glyoxal and Kethoxal (β-ethoxy-α-keto-butyraldehyde) are shown to inactivate tobacco mosaic virus and its isolated nucleic acid, the free nucleic acid being inactivated at much lower reagent concentrations. The inactivation is compared with that of formaldehyde and it is concluded that in the intact virus also it is the reaction with the nucleic acid which leads to inactivation. Spectrophotometrically it is shown that glyoxal and its derivatives react very rapidly with guanine derivatives. The properties of the reaction products of Kethoxal with guanosine and isocytosine are described and the nature of the chemical reaction is discussed. Various glyoxal derivatives which are active antiviral agents give rise to similar changes in the spectrum of guanylic acid, whereas inactive ones do not." @default.
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- W2060026013 date "1959-02-01" @default.
- W2060026013 modified "2023-09-25" @default.
- W2060026013 title "Inactivation of virus nucleic acid with glyoxal derivatives" @default.
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- W2060026013 doi "https://doi.org/10.1016/0006-3002(59)90019-8" @default.
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