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• W2060028989 abstract "The double-stranded RNA dependent protein kinase (PKR) is a negative regulator of cell proliferation and thus itself a target for modulation. We show that a cell-permeable peptide (PRI), containing a conserved double-stranded RNA binding motif found in PKR, inhibits activation of the kinase and activity to phosphorylate its substrate. Further, the PRI-peptide localizes to the cytoplasm of murine embryonic fibroblasts and ablates cellular PKR activation. The PRI-peptide enhances cell proliferation compared to treatment with a variant control peptide, resulting in cultures with increased cell density. We conclude that peptides that interfere with PKR may be useful tools for regulating cell proliferation." @default.
• W2060028989 created "2016-06-24" @default.
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• W2060028989 date "2000-10-01" @default.
• W2060028989 modified "2023-09-26" @default.
• W2060028989 title "A cell-permeable peptide inhibits activation of PKR and enhances cell proliferation" @default.
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• W2060028989 doi "https://doi.org/10.1016/s0196-9781(00)00297-7" @default.
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