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- W2060034577 abstract "Abstract A number of laboratories have modeled aspects of synaptic plasticity using neuronal networks established on micro‐electrode arrays. Such studies demonstrate that external stimulation can increase or hasten maturation of network signaling as evidenced an increase in complex bursts. Herein, we demonstrate that repetitive stimulation with a recorded synaptic signal was capable of increasing overall signaling, including the percentage of bursts, over a 5‐day period, but that this increase was completely prevented by the presence of the GABAergic antagonist bicuculline. These findings demonstrate a critical role for inhibitory neurons in signal maturation following stimulation, which supports the purported role for inhibitory neuronal activity in long‐term potentiation and learning in situ ." @default.
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- W2060034577 date "2013-04-03" @default.
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- W2060034577 title "Critical role for inhibitory neurons in modulation of synaptic signaling in ex vivo neuronal networks" @default.
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- W2060034577 doi "https://doi.org/10.1016/j.ijdevneu.2013.03.011" @default.
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