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• W2060037527 abstract "With the growing number of patients suffering from central nervous system (CNS) diseases a suitable approach for drug targeting to the brain becomes more and more important. In the present study, the contribution of the nose–CSF pathway to the uptake of the model drug fluorescein isothiocyanate-labelled dextran with a molecular weight of 3.0 kDa (FD3) into the CSF was determined in rats. FD3 was administered intranasally (489 μg/rat) and by intravenous infusion (24.4 μg/ml; 119 μg/rat) in the same set of animals (n=6). Blood samples were taken from the tail vein and CSF was sampled by cisternal puncture using a stereotaxic frame. The contribution of the olfactory pathway to the uptake of FD3 into the CSF was determined by comparing the AUCCSF/AUCplasma ratios after intranasal and after intravenous application of FD3 mimicking the blood levels after intranasal delivery. No significant difference was observed between the AUCCSF/AUCplasma ratios of FD3 after intranasal administration (1.33±0.40%) and intravenous infusion (1.03±0.56%). This indicates that in rats about 1% of the amount of FD3 in plasma reaches the CSF both after nasal and intravenous administration and that no direct transport of FD3 from the nose–CSF could be found." @default.
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• W2060037527 date "2005-09-01" @default.
• W2060037527 modified "2023-10-15" @default.
• W2060037527 title "Uptake of fluorescein isothiocyanate-labelled dextran into the CSF after intranasal and intravenous administration to rats" @default.
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• W2060037527 doi "https://doi.org/10.1016/j.ejpb.2005.02.015" @default.
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