Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060062311> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2060062311 abstract "The epidermal growth factor receptor (EGFR) (ErbB1) and HER-2/neu (ErbB2) are members of the ErbB family of receptor tyrosine kinases. These receptors are overexpressed in a variety of human tumors and overexpression generally correlates with poor prognosis and decreased survival. Lapatinib, a reversible inhibitor of both EGFR and HER-2/neu, has shown some success in achieving clinical responses in heavily pretreated advanced cancer patients. GW2974 is a reversible dual inhibitor similar to lapatinib, but GW2974 was not progressed to clinical trials due to pharmacokinetic issues. Bcl-2, an anti-apoptotic protein, is also overexpressed in a number of human tumors. Bcl-2 inhibitors induce apoptosis and sensitize cancer cells to other therapies. The purpose of this study was to assess the effects of combining ErbB and Bcl-2 inhibitors on the growth of human breast cancer cell lines. EGFR/HER-2/neu tyrosine kinase inhibitors (lapatinib and GW2974) were combined with Bcl-2 inhibitors (HA14-1 or GX15-070) and the anti-proliferative effects were determined by the MTT tetrazolium dye assay. Combinations were tested in MCF-7 human breast cancer cells, a HER-2/neu transfected MCF-7 cell line (MCF/18), and a tamoxifen-resistant MCF-7 cell line (MTR-3). A synergistic inhibitory effect was observed with the combination of inhibitors of EGFR-HER-2/neu (lapatinib or GW2974) and Bcl-2 (GX15-070 or HA14-1) on the growth of the MCF-7, MCF/18, and MTR-3 human breast cancer cell lines. This study suggests that simultaneously blocking the ErbB family of receptor tyrosine kinases and Bcl-2 family of proteins may be a benefit to breast cancer patients." @default.
- W2060062311 created "2016-06-24" @default.
- W2060062311 creator A5034792070 @default.
- W2060062311 creator A5038569415 @default.
- W2060062311 creator A5047198395 @default.
- W2060062311 creator A5073311894 @default.
- W2060062311 creator A5076058689 @default.
- W2060062311 creator A5089969677 @default.
- W2060062311 date "2007-02-01" @default.
- W2060062311 modified "2023-10-14" @default.
- W2060062311 title "Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor" @default.
- W2060062311 doi "https://doi.org/10.3892/or.17.2.465" @default.
- W2060062311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17203189" @default.
- W2060062311 hasPublicationYear "2007" @default.
- W2060062311 type Work @default.
- W2060062311 sameAs 2060062311 @default.
- W2060062311 citedByCount "20" @default.
- W2060062311 countsByYear W20600623112012 @default.
- W2060062311 countsByYear W20600623112014 @default.
- W2060062311 countsByYear W20600623112015 @default.
- W2060062311 countsByYear W20600623112016 @default.
- W2060062311 countsByYear W20600623112018 @default.
- W2060062311 countsByYear W20600623112019 @default.
- W2060062311 countsByYear W20600623112021 @default.
- W2060062311 countsByYear W20600623112022 @default.
- W2060062311 crossrefType "journal-article" @default.
- W2060062311 hasAuthorship W2060062311A5034792070 @default.
- W2060062311 hasAuthorship W2060062311A5038569415 @default.
- W2060062311 hasAuthorship W2060062311A5047198395 @default.
- W2060062311 hasAuthorship W2060062311A5073311894 @default.
- W2060062311 hasAuthorship W2060062311A5076058689 @default.
- W2060062311 hasAuthorship W2060062311A5089969677 @default.
- W2060062311 hasBestOaLocation W20600623111 @default.
- W2060062311 hasConcept C101544691 @default.
- W2060062311 hasConcept C109541995 @default.
- W2060062311 hasConcept C121608353 @default.
- W2060062311 hasConcept C126322002 @default.
- W2060062311 hasConcept C184235292 @default.
- W2060062311 hasConcept C190283241 @default.
- W2060062311 hasConcept C2777329042 @default.
- W2060062311 hasConcept C2778820342 @default.
- W2060062311 hasConcept C2779251935 @default.
- W2060062311 hasConcept C2779438470 @default.
- W2060062311 hasConcept C2779786085 @default.
- W2060062311 hasConcept C2994423619 @default.
- W2060062311 hasConcept C502942594 @default.
- W2060062311 hasConcept C530470458 @default.
- W2060062311 hasConcept C55493867 @default.
- W2060062311 hasConcept C71924100 @default.
- W2060062311 hasConcept C86803240 @default.
- W2060062311 hasConcept C95444343 @default.
- W2060062311 hasConcept C96232424 @default.
- W2060062311 hasConceptScore W2060062311C101544691 @default.
- W2060062311 hasConceptScore W2060062311C109541995 @default.
- W2060062311 hasConceptScore W2060062311C121608353 @default.
- W2060062311 hasConceptScore W2060062311C126322002 @default.
- W2060062311 hasConceptScore W2060062311C184235292 @default.
- W2060062311 hasConceptScore W2060062311C190283241 @default.
- W2060062311 hasConceptScore W2060062311C2777329042 @default.
- W2060062311 hasConceptScore W2060062311C2778820342 @default.
- W2060062311 hasConceptScore W2060062311C2779251935 @default.
- W2060062311 hasConceptScore W2060062311C2779438470 @default.
- W2060062311 hasConceptScore W2060062311C2779786085 @default.
- W2060062311 hasConceptScore W2060062311C2994423619 @default.
- W2060062311 hasConceptScore W2060062311C502942594 @default.
- W2060062311 hasConceptScore W2060062311C530470458 @default.
- W2060062311 hasConceptScore W2060062311C55493867 @default.
- W2060062311 hasConceptScore W2060062311C71924100 @default.
- W2060062311 hasConceptScore W2060062311C86803240 @default.
- W2060062311 hasConceptScore W2060062311C95444343 @default.
- W2060062311 hasConceptScore W2060062311C96232424 @default.
- W2060062311 hasLocation W20600623111 @default.
- W2060062311 hasLocation W20600623112 @default.
- W2060062311 hasOpenAccess W2060062311 @default.
- W2060062311 hasPrimaryLocation W20600623111 @default.
- W2060062311 hasRelatedWork W159758821 @default.
- W2060062311 hasRelatedWork W2006253236 @default.
- W2060062311 hasRelatedWork W2048136894 @default.
- W2060062311 hasRelatedWork W2080550759 @default.
- W2060062311 hasRelatedWork W2091186091 @default.
- W2060062311 hasRelatedWork W2127154017 @default.
- W2060062311 hasRelatedWork W2161139034 @default.
- W2060062311 hasRelatedWork W2340787755 @default.
- W2060062311 hasRelatedWork W2415297221 @default.
- W2060062311 hasRelatedWork W2900933517 @default.
- W2060062311 isParatext "false" @default.
- W2060062311 isRetracted "false" @default.
- W2060062311 magId "2060062311" @default.
- W2060062311 workType "article" @default.