FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060065563> ?p ?o ?g. }

• W2060065563 endingPage "e1003231" @default.
• W2060065563 startingPage "e1003231" @default.
• W2060065563 abstract "Enterovirus 71 (EV71) is the major causative pathogen of hand, foot, and mouth disease (HFMD). Its pathogenicity is not fully understood, but innate immune evasion is likely a key factor. Strategies to circumvent the initiation and effector phases of anti-viral innate immunity are well known; less well known is whether EV71 evades the signal transduction phase regulated by a sophisticated interplay of cellular and viral proteins. Here, we show that EV71 inhibits anti-viral type I interferon (IFN) responses by targeting the mitochondrial anti-viral signaling (MAVS) protein—a unique adaptor molecule activated upon retinoic acid induced gene-I (RIG-I) and melanoma differentiation associated gene (MDA-5) viral recognition receptor signaling—upstream of type I interferon production. MAVS was cleaved and released from mitochondria during EV71 infection. An in vitro cleavage assay demonstrated that the viral 2A protease (2Apro), but not the mutant 2Apro (2Apro-110) containing an inactivated catalytic site, cleaved MAVS. The Protease-Glo assay revealed that MAVS was cleaved at 3 residues between the proline-rich and transmembrane domains, and the resulting fragmentation effectively inactivated downstream signaling. In addition to MAVS cleavage, we found that EV71 infection also induced morphologic and functional changes to the mitochondria. The EV71 structural protein VP1 was detected on purified mitochondria, suggesting not only a novel role for mitochondria in the EV71 replication cycle but also an explanation of how EV71-derived 2Apro could approach MAVS. Taken together, our findings reveal a novel strategy employed by EV71 to escape host anti-viral innate immunity that complements the known EV71-mediated immune-evasion mechanisms." @default.
• W2060065563 created "2016-06-24" @default.
• W2060065563 creator A5018551141 @default.
• W2060065563 creator A5020383361 @default.
• W2060065563 creator A5041204026 @default.
• W2060065563 creator A5042669318 @default.
• W2060065563 creator A5049849594 @default.
• W2060065563 creator A5056806990 @default.
• W2060065563 creator A5066332067 @default.
• W2060065563 creator A5072859441 @default.
• W2060065563 date "2013-03-21" @default.
• W2060065563 modified "2023-10-18" @default.
• W2060065563 title "Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses" @default.
• W2060065563 cites W1574729593 @default.
• W2060065563 cites W1627251303 @default.
• W2060065563 cites W1775199813 @default.
• W2060065563 cites W1912763515 @default.
• W2060065563 cites W1966062488 @default.
• W2060065563 cites W1966390603 @default.
• W2060065563 cites W1967686012 @default.
• W2060065563 cites W1968637854 @default.
• W2060065563 cites W1974363716 @default.
• W2060065563 cites W1977567283 @default.
• W2060065563 cites W1982254939 @default.
• W2060065563 cites W1986091547 @default.
• W2060065563 cites W1987375010 @default.
• W2060065563 cites W1988808478 @default.
• W2060065563 cites W1993205112 @default.
• W2060065563 cites W1998332163 @default.
• W2060065563 cites W2008200591 @default.
• W2060065563 cites W2009027960 @default.
• W2060065563 cites W2011265690 @default.
• W2060065563 cites W2013092102 @default.
• W2060065563 cites W2015130126 @default.
• W2060065563 cites W2018828712 @default.
• W2060065563 cites W2020942480 @default.
• W2060065563 cites W2031253712 @default.
• W2060065563 cites W2032539461 @default.
• W2060065563 cites W2040589516 @default.
• W2060065563 cites W2044006050 @default.
• W2060065563 cites W2044105820 @default.
• W2060065563 cites W2047478551 @default.
• W2060065563 cites W2059395206 @default.
• W2060065563 cites W2061792582 @default.
• W2060065563 cites W2068518836 @default.
• W2060065563 cites W2071670416 @default.
• W2060065563 cites W2073092202 @default.
• W2060065563 cites W2091978007 @default.
• W2060065563 cites W2093579074 @default.
• W2060065563 cites W2094999489 @default.
• W2060065563 cites W2095401221 @default.
• W2060065563 cites W2099315132 @default.
• W2060065563 cites W2100008113 @default.
• W2060065563 cites W2100145928 @default.
• W2060065563 cites W2102606446 @default.
• W2060065563 cites W2107513655 @default.
• W2060065563 cites W2109265999 @default.
• W2060065563 cites W2111205315 @default.
• W2060065563 cites W2120633733 @default.
• W2060065563 cites W2121971955 @default.
• W2060065563 cites W2128175717 @default.
• W2060065563 cites W2132669016 @default.
• W2060065563 cites W2137303998 @default.
• W2060065563 cites W2140530928 @default.
• W2060065563 cites W2140700343 @default.
• W2060065563 cites W2144611757 @default.
• W2060065563 cites W2147727360 @default.
• W2060065563 cites W2149276150 @default.
• W2060065563 cites W2151901780 @default.
• W2060065563 cites W2152964042 @default.
• W2060065563 cites W2158389997 @default.
• W2060065563 cites W2159779332 @default.
• W2060065563 cites W2162245456 @default.
• W2060065563 cites W2163279527 @default.
• W2060065563 cites W2165748936 @default.
• W2060065563 cites W2166454224 @default.
• W2060065563 cites W2170643754 @default.
• W2060065563 doi "https://doi.org/10.1371/journal.ppat.1003231" @default.
• W2060065563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3605153" @default.
• W2060065563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23555247" @default.
• W2060065563 hasPublicationYear "2013" @default.
• W2060065563 type Work @default.
• W2060065563 sameAs 2060065563 @default.
• W2060065563 citedByCount "191" @default.
• W2060065563 countsByYear W20600655632013 @default.
• W2060065563 countsByYear W20600655632014 @default.
• W2060065563 countsByYear W20600655632015 @default.
• W2060065563 countsByYear W20600655632016 @default.
• W2060065563 countsByYear W20600655632017 @default.
• W2060065563 countsByYear W20600655632018 @default.
• W2060065563 countsByYear W20600655632019 @default.
• W2060065563 countsByYear W20600655632020 @default.
• W2060065563 countsByYear W20600655632021 @default.
• W2060065563 countsByYear W20600655632022 @default.
• W2060065563 countsByYear W20600655632023 @default.
• W2060065563 crossrefType "journal-article" @default.
• W2060065563 hasAuthorship W2060065563A5018551141 @default.
• W2060065563 hasAuthorship W2060065563A5020383361 @default.

• next