Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060075520> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2060075520 endingPage "455" @default.
- W2060075520 startingPage "443" @default.
- W2060075520 abstract "Two hydroxylation reactions of m-cresol, an intermediate in the secondary biosynthesis of the antibiotic patulin, have been characterised in cell-free preparations of Penicillium patulum. The ability to convert m-cresol to 2,5-dihydroxytoluene and m-hydroxybenzyl alcohol is located in separable fractions of the 105000 × g microsomal pellet. The activities had Km values for m-cresol of 80 μM and 5 μM, respectively. Both reactions require molecular oxygen and NADPH for activity. Inhibition of m-cresol hydroxylases by carbon monoxide is reversible by light with a photochemical action spectrum maximal at 450 nm. Carbon monoxide difference spectra of mycel extracts show the presence of absorbing pigments at 422 and 450–455 nm. The enzymes are not appreciably inhibited by cyanide but are inhibited by cytochrome c. m-Cresol hydroxylation therefore appears to be catalysed by typical mixed-function oxidases involving an NADPH-dependent reductase and a pigment like cytochrome P-450. In the light of studies on the utilisation of radioactively labelled intermediates, the methyl hydroxylation of m-cresol to m-hydroxybenzyl alcohol probably represents an important reaction in the sequence leading to patulin formation. Ring hydroxylation of m-cresol to 2,5-dihydroxytoluene appears to be a side reaction functional at higher concentrations of m-cresol." @default.
- W2060075520 created "2016-06-24" @default.
- W2060075520 creator A5010008030 @default.
- W2060075520 creator A5014900027 @default.
- W2060075520 creator A5016235541 @default.
- W2060075520 creator A5087773365 @default.
- W2060075520 date "1974-11-01" @default.
- W2060075520 modified "2023-10-03" @default.
- W2060075520 title "Patulin Biosynthesis: The Role of Mixed-Function Oxidases in the Hydroxylation of m-Cresol" @default.
- W2060075520 cites W1482154419 @default.
- W2060075520 cites W1483556659 @default.
- W2060075520 cites W1503485436 @default.
- W2060075520 cites W1506043065 @default.
- W2060075520 cites W1527521375 @default.
- W2060075520 cites W1577480508 @default.
- W2060075520 cites W1673905022 @default.
- W2060075520 cites W1859731575 @default.
- W2060075520 cites W1951469402 @default.
- W2060075520 cites W1975784551 @default.
- W2060075520 cites W1980314952 @default.
- W2060075520 cites W1983654116 @default.
- W2060075520 cites W1996833801 @default.
- W2060075520 cites W2012289596 @default.
- W2060075520 cites W2012933367 @default.
- W2060075520 cites W2037848761 @default.
- W2060075520 cites W2043126260 @default.
- W2060075520 cites W2045471061 @default.
- W2060075520 cites W2046559874 @default.
- W2060075520 cites W2058855637 @default.
- W2060075520 cites W2059836007 @default.
- W2060075520 cites W2072415579 @default.
- W2060075520 cites W2073892634 @default.
- W2060075520 cites W2080810588 @default.
- W2060075520 cites W2086032175 @default.
- W2060075520 cites W2168575702 @default.
- W2060075520 cites W2332740222 @default.
- W2060075520 cites W4240517159 @default.
- W2060075520 doi "https://doi.org/10.1111/j.1432-1033.1974.tb03849.x" @default.
- W2060075520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4442421" @default.
- W2060075520 hasPublicationYear "1974" @default.
- W2060075520 type Work @default.
- W2060075520 sameAs 2060075520 @default.
- W2060075520 citedByCount "35" @default.
- W2060075520 countsByYear W20600755202017 @default.
- W2060075520 crossrefType "journal-article" @default.
- W2060075520 hasAuthorship W2060075520A5010008030 @default.
- W2060075520 hasAuthorship W2060075520A5014900027 @default.
- W2060075520 hasAuthorship W2060075520A5016235541 @default.
- W2060075520 hasAuthorship W2060075520A5087773365 @default.
- W2060075520 hasBestOaLocation W20600755201 @default.
- W2060075520 hasConcept C134651460 @default.
- W2060075520 hasConcept C178790620 @default.
- W2060075520 hasConcept C181199279 @default.
- W2060075520 hasConcept C185592680 @default.
- W2060075520 hasConcept C2777401367 @default.
- W2060075520 hasConcept C2777702071 @default.
- W2060075520 hasConcept C2778455166 @default.
- W2060075520 hasConcept C2779550045 @default.
- W2060075520 hasConcept C2780768313 @default.
- W2060075520 hasConcept C2781109383 @default.
- W2060075520 hasConcept C31903555 @default.
- W2060075520 hasConcept C71240020 @default.
- W2060075520 hasConcept C84699730 @default.
- W2060075520 hasConceptScore W2060075520C134651460 @default.
- W2060075520 hasConceptScore W2060075520C178790620 @default.
- W2060075520 hasConceptScore W2060075520C181199279 @default.
- W2060075520 hasConceptScore W2060075520C185592680 @default.
- W2060075520 hasConceptScore W2060075520C2777401367 @default.
- W2060075520 hasConceptScore W2060075520C2777702071 @default.
- W2060075520 hasConceptScore W2060075520C2778455166 @default.
- W2060075520 hasConceptScore W2060075520C2779550045 @default.
- W2060075520 hasConceptScore W2060075520C2780768313 @default.
- W2060075520 hasConceptScore W2060075520C2781109383 @default.
- W2060075520 hasConceptScore W2060075520C31903555 @default.
- W2060075520 hasConceptScore W2060075520C71240020 @default.
- W2060075520 hasConceptScore W2060075520C84699730 @default.
- W2060075520 hasIssue "2" @default.
- W2060075520 hasLocation W20600755201 @default.
- W2060075520 hasLocation W20600755202 @default.
- W2060075520 hasOpenAccess W2060075520 @default.
- W2060075520 hasPrimaryLocation W20600755201 @default.
- W2060075520 hasRelatedWork W1515458478 @default.
- W2060075520 hasRelatedWork W154223318 @default.
- W2060075520 hasRelatedWork W1943555017 @default.
- W2060075520 hasRelatedWork W2000231925 @default.
- W2060075520 hasRelatedWork W2000728040 @default.
- W2060075520 hasRelatedWork W2024218710 @default.
- W2060075520 hasRelatedWork W2066899148 @default.
- W2060075520 hasRelatedWork W2072745548 @default.
- W2060075520 hasRelatedWork W2073720507 @default.
- W2060075520 hasRelatedWork W2091954047 @default.
- W2060075520 hasVolume "49" @default.
- W2060075520 isParatext "false" @default.
- W2060075520 isRetracted "false" @default.
- W2060075520 magId "2060075520" @default.
- W2060075520 workType "article" @default.