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- W2060082213 abstract "Women with a prior spontaneous preterm birth (SPTB) and/or prior or current cervical insufficiency may be candidates for both supplementation with 17-alpha hydroxyprogesterone caproate (17P) and cervical cerclage placement. However, the relationship between the simultaneous use of these interventions and SPTB is uncertain. We sought to examine pregnancy outcomes among women with cerclage with and without 17P. Retrospective cohort of women with singleton pregnancies from 2 tertiary-care centers 2009-2012. Women undergoing cervical cerclage placement for any indication <26 weeks were included. Women who also received 17P prophylaxis (cerclage+17P group) were compared to those who did not receive 17P (cerclage-only group). Data were analyzed with Chi-square, Student's t-test, and logistic regression. 87 women were included; 39 (44.8%) received 17P. Women in the cerclage+17P group did not differ from those in the cerclage-only group with regards to earliest prior SPTB (23.3 vs. 23.2, p=0.96) or number of prior PTB (median=1 for both groups). Other characteristics and outcomes also were similar among groups (Table). Survival analysis revealed no differences in delivery gestational age based on 17P (Figure). In regression analyses controlling for potential confounders, 17P use was not associated with pregnancy prolongation.Tabled 1Antenatal characteristics and pregnancy outcomes among women with cerclage, stratified by 17P supplementationData are n (%) unless otherwise indicatedView Large Image Figure ViewerDownload Hi-res image Download (PPT) Among women with a cervical cerclage, the addition of 17P does not appear to prolong pregnancy, and overall rates of prematurity are high. Larger studies should confirm this finding and further investigate additional preventative strategies for women with cervical insufficiency." @default.
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- W2060082213 date "2013-01-01" @default.
- W2060082213 modified "2023-09-23" @default.
- W2060082213 title "529: Cervical cerclage, progesterone supplementation, and spontaneous preterm birth" @default.
- W2060082213 doi "https://doi.org/10.1016/j.ajog.2012.10.695" @default.
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