Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060093119> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2060093119 endingPage "54" @default.
- W2060093119 startingPage "41" @default.
- W2060093119 abstract "Rapid detection of biologically active natural products plays a key role in the phytochemical investigation of crude plant extracts. In order to perform an efficient screening of the extracts, both biological assays and HPLC analysis with various detection methods are used. Techniques such as HPLC coupled to UV photodiode array detection (LC/DAD-UV) and to mass spectrometry (LC/MS or LC/MS/MS) provide numerous on-line structural data on the metabolites prior to isolation. The recent introduction of HPLC coupled to nuclear magnetic resonance (LC/NMR) represents a powerful complement to LC/UV/MS screening. Various plant species belonging to the Gentianaceae and Leguminosae have been analysed by LC/UV, LC/MS, LC/MS/MS and LC/NMR. These hyphenated techniques allow a rapid structural determination of known plant constituents with only a minute amount of plant material. Simple bioautographic assays such as those used for screening antifungal constituents can also be performed on-line directly by collecting HPLC peaks and measuring the activity against the fungi of interest. These bioassays permit a rapid localisation of the bioactive natural products. With such a combined approach, the time consuming isolation of common natural products is avoided and an efficient targeted isolation of compounds presenting interesting spectroscopical or biological features is performed. Several representative applications of the use of LC/MS and LC/NMR for the dereplication and identification of antifungal constituents are presented in the present paper." @default.
- W2060093119 created "2016-06-24" @default.
- W2060093119 creator A5052105510 @default.
- W2060093119 creator A5056051113 @default.
- W2060093119 creator A5063334549 @default.
- W2060093119 date "2000-12-01" @default.
- W2060093119 modified "2023-10-10" @default.
- W2060093119 title "The Importance Of LC-MS And LC-NMR In The Discovery Of New Lead Compounds From Plants" @default.
- W2060093119 cites W1967751465 @default.
- W2060093119 cites W1972085795 @default.
- W2060093119 cites W1979280039 @default.
- W2060093119 cites W1998313361 @default.
- W2060093119 cites W2000983103 @default.
- W2060093119 cites W2001109410 @default.
- W2060093119 cites W2008568054 @default.
- W2060093119 cites W2016270920 @default.
- W2060093119 cites W2035696576 @default.
- W2060093119 cites W2039969698 @default.
- W2060093119 cites W2057626669 @default.
- W2060093119 cites W2078344952 @default.
- W2060093119 cites W2082289906 @default.
- W2060093119 cites W2085148311 @default.
- W2060093119 cites W2091041815 @default.
- W2060093119 cites W2091211091 @default.
- W2060093119 cites W2092524308 @default.
- W2060093119 cites W2095600448 @default.
- W2060093119 cites W2137530063 @default.
- W2060093119 cites W2493744474 @default.
- W2060093119 doi "https://doi.org/10.1076/phbi.38.6.41.5957" @default.
- W2060093119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23531137" @default.
- W2060093119 hasPublicationYear "2000" @default.
- W2060093119 type Work @default.
- W2060093119 sameAs 2060093119 @default.
- W2060093119 citedByCount "29" @default.
- W2060093119 countsByYear W20600931192012 @default.
- W2060093119 countsByYear W20600931192015 @default.
- W2060093119 countsByYear W20600931192020 @default.
- W2060093119 countsByYear W20600931192021 @default.
- W2060093119 countsByYear W20600931192022 @default.
- W2060093119 crossrefType "journal-article" @default.
- W2060093119 hasAuthorship W2060093119A5052105510 @default.
- W2060093119 hasAuthorship W2060093119A5056051113 @default.
- W2060093119 hasAuthorship W2060093119A5063334549 @default.
- W2060093119 hasConcept C104488531 @default.
- W2060093119 hasConcept C162356407 @default.
- W2060093119 hasConcept C179998833 @default.
- W2060093119 hasConcept C185592680 @default.
- W2060093119 hasConcept C195475562 @default.
- W2060093119 hasConcept C2779548794 @default.
- W2060093119 hasConcept C43617362 @default.
- W2060093119 hasConcept C54355233 @default.
- W2060093119 hasConcept C55493867 @default.
- W2060093119 hasConcept C64489805 @default.
- W2060093119 hasConcept C86803240 @default.
- W2060093119 hasConcept C89423630 @default.
- W2060093119 hasConceptScore W2060093119C104488531 @default.
- W2060093119 hasConceptScore W2060093119C162356407 @default.
- W2060093119 hasConceptScore W2060093119C179998833 @default.
- W2060093119 hasConceptScore W2060093119C185592680 @default.
- W2060093119 hasConceptScore W2060093119C195475562 @default.
- W2060093119 hasConceptScore W2060093119C2779548794 @default.
- W2060093119 hasConceptScore W2060093119C43617362 @default.
- W2060093119 hasConceptScore W2060093119C54355233 @default.
- W2060093119 hasConceptScore W2060093119C55493867 @default.
- W2060093119 hasConceptScore W2060093119C64489805 @default.
- W2060093119 hasConceptScore W2060093119C86803240 @default.
- W2060093119 hasConceptScore W2060093119C89423630 @default.
- W2060093119 hasIssue "sup1" @default.
- W2060093119 hasLocation W20600931191 @default.
- W2060093119 hasLocation W20600931192 @default.
- W2060093119 hasOpenAccess W2060093119 @default.
- W2060093119 hasPrimaryLocation W20600931191 @default.
- W2060093119 hasRelatedWork W1814236319 @default.
- W2060093119 hasRelatedWork W1971600241 @default.
- W2060093119 hasRelatedWork W2026681536 @default.
- W2060093119 hasRelatedWork W2073076114 @default.
- W2060093119 hasRelatedWork W2136476259 @default.
- W2060093119 hasRelatedWork W2186086384 @default.
- W2060093119 hasRelatedWork W2368899332 @default.
- W2060093119 hasRelatedWork W2462695612 @default.
- W2060093119 hasRelatedWork W4386696306 @default.
- W2060093119 hasRelatedWork W3088223198 @default.
- W2060093119 hasVolume "38" @default.
- W2060093119 isParatext "false" @default.
- W2060093119 isRetracted "false" @default.
- W2060093119 magId "2060093119" @default.
- W2060093119 workType "article" @default.