Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060093889> ?p ?o ?g. }
- W2060093889 endingPage "298" @default.
- W2060093889 startingPage "288" @default.
- W2060093889 abstract "Oxidative stress has been implicated in pesticide-induced neurotoxicity, based on its role in the cascade of biochemical changes that lead to dopaminergic neuronal cell death. We have, therefore, examined the role of oxidative stress caused by the pesticides endosulfan and zineb in human neuroblastoma cells (SH-SY5Y) in culture. Upon treatment with 50-200 μM concentrations of either of these pesticides, SH-SY5Y cells generated both superoxide anion and hydrogen peroxide in a dose-and time-dependent manner. Mixtures of the pesticides significantly enhanced the production of these reactive oxygen species compared to individual pesticide exposures. Pesticide treatment decreased superoxide dismutase, glutathione peroxidase, and catalase activities in SH-SY5Y cells. Additionally, these pesticides induced lipid peroxide (thiobarbituric acid reactive products) formation in these cells. While both pesticides individually (at 100 μM) increased caspase-3 activity, cells exposed to a mixture of the pesticides exhibited significantly low levels of this enzyme, probably due to excessive necrotic cell death. Furthermore, exposure to these pesticides increased nuclear NFκB activity. Taken together, these findings suggest that the cytotoxicity of endosulfan and zineb, both individually and in mixtures may, at least in part, be associated with the generation of reactive oxygen species with concomitant increased expression of NFκB." @default.
- W2060093889 created "2016-06-24" @default.
- W2060093889 creator A5016835731 @default.
- W2060093889 creator A5070551497 @default.
- W2060093889 date "2007-01-01" @default.
- W2060093889 modified "2023-10-14" @default.
- W2060093889 title "Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: Role of NFκB and caspase-3" @default.
- W2060093889 cites W1008129826 @default.
- W2060093889 cites W1497910723 @default.
- W2060093889 cites W1519250999 @default.
- W2060093889 cites W1519733404 @default.
- W2060093889 cites W1568529372 @default.
- W2060093889 cites W1569497692 @default.
- W2060093889 cites W1573635219 @default.
- W2060093889 cites W1577255033 @default.
- W2060093889 cites W1590514634 @default.
- W2060093889 cites W1734090629 @default.
- W2060093889 cites W1768247331 @default.
- W2060093889 cites W1911014954 @default.
- W2060093889 cites W1914572002 @default.
- W2060093889 cites W1966394241 @default.
- W2060093889 cites W1968303737 @default.
- W2060093889 cites W1971424572 @default.
- W2060093889 cites W1975416756 @default.
- W2060093889 cites W1975924701 @default.
- W2060093889 cites W1976385326 @default.
- W2060093889 cites W1976576980 @default.
- W2060093889 cites W1978324040 @default.
- W2060093889 cites W1979980294 @default.
- W2060093889 cites W1983442327 @default.
- W2060093889 cites W1987610744 @default.
- W2060093889 cites W1988993069 @default.
- W2060093889 cites W1989405078 @default.
- W2060093889 cites W1991040512 @default.
- W2060093889 cites W1991945233 @default.
- W2060093889 cites W2001790945 @default.
- W2060093889 cites W2004396549 @default.
- W2060093889 cites W2004798196 @default.
- W2060093889 cites W2005158018 @default.
- W2060093889 cites W2006704376 @default.
- W2060093889 cites W2007861801 @default.
- W2060093889 cites W2008935907 @default.
- W2060093889 cites W2009351391 @default.
- W2060093889 cites W2011913768 @default.
- W2060093889 cites W2014868323 @default.
- W2060093889 cites W2017857028 @default.
- W2060093889 cites W2019633700 @default.
- W2060093889 cites W2020567039 @default.
- W2060093889 cites W2020984846 @default.
- W2060093889 cites W2021620432 @default.
- W2060093889 cites W2025297620 @default.
- W2060093889 cites W2027593755 @default.
- W2060093889 cites W2028382049 @default.
- W2060093889 cites W2030518723 @default.
- W2060093889 cites W2032776260 @default.
- W2060093889 cites W2032971839 @default.
- W2060093889 cites W2035111849 @default.
- W2060093889 cites W2037977556 @default.
- W2060093889 cites W2039629489 @default.
- W2060093889 cites W2047641274 @default.
- W2060093889 cites W2048184052 @default.
- W2060093889 cites W2048719661 @default.
- W2060093889 cites W2049141234 @default.
- W2060093889 cites W2051471929 @default.
- W2060093889 cites W2051652489 @default.
- W2060093889 cites W2052583566 @default.
- W2060093889 cites W2052947854 @default.
- W2060093889 cites W2053032861 @default.
- W2060093889 cites W2053898989 @default.
- W2060093889 cites W2054351060 @default.
- W2060093889 cites W2054415450 @default.
- W2060093889 cites W2055718278 @default.
- W2060093889 cites W2056291273 @default.
- W2060093889 cites W2057323378 @default.
- W2060093889 cites W2060348975 @default.
- W2060093889 cites W2060508329 @default.
- W2060093889 cites W2062412222 @default.
- W2060093889 cites W2062895765 @default.
- W2060093889 cites W2065700794 @default.
- W2060093889 cites W2068994750 @default.
- W2060093889 cites W2072334716 @default.
- W2060093889 cites W2072415705 @default.
- W2060093889 cites W2073179464 @default.
- W2060093889 cites W2073756411 @default.
- W2060093889 cites W2075125380 @default.
- W2060093889 cites W2076689230 @default.
- W2060093889 cites W2077724894 @default.
- W2060093889 cites W2077834535 @default.
- W2060093889 cites W2080049988 @default.
- W2060093889 cites W2081088683 @default.
- W2060093889 cites W2082240251 @default.
- W2060093889 cites W2082798387 @default.
- W2060093889 cites W2083676758 @default.
- W2060093889 cites W2084542414 @default.
- W2060093889 cites W2089303587 @default.
- W2060093889 cites W2091375059 @default.
- W2060093889 cites W2093246591 @default.
- W2060093889 cites W2096298540 @default.