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• W2060095154 abstract "Difluoromethylated arenes are one of the privileged structural motifs that are important for fine tuning the biological properties of drug molecules. No general catalytic method exists for the formation of difluoromethylarenes. Previous methods for the preparation of difluoromethylarenes typically required harsh conditions, multiple steps or stoichiometric amount of catalysts. Here we report a cooperative dual palladium/silver catalyst system for direct difluoromethylation of aryl bromides and iodides under mild conditions. We develop the system by initial preparation of the putative intermediates in the dual-catalytic cycles, followed by studying the elemental steps to demonstrate the viability of the proposed cooperative catalytic cycle. The reaction is compatible with a variety of functional groups such as ester, amide, protected phenoxide, protected ketone, cyclopropyl, bromide and heteroaryl subunits such as pyrrole, benzothiazole, carbazole or pyridine. Difluoromethylation of organic molecules typically requires stoichiometric metal salts or harsh conditions. Here, the authors report a dual metal catalytic system for difluoromethylation allowing mild and direct functionalization of aryl halides, including highly functionalized molecules." @default.
• W2060095154 created "2016-06-24" @default.
• W2060095154 creator A5010215438 @default.
• W2060095154 creator A5019368353 @default.
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• W2060095154 date "2014-11-07" @default.
• W2060095154 modified "2023-10-06" @default.
• W2060095154 title "Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides" @default.
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• W2060095154 doi "https://doi.org/10.1038/ncomms6405" @default.
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