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• W2060097706 abstract "The regional distribution and chromatographic characteristics of somatostatin-like immunoreactivity (SLI) were studied in autopsy specimens of 8 human brains. SLI concentrations in 8 different regions of these brains ranged from (mean±S.E.) 756.3 ± 363.4 pmol/g tissue in anterior hypothalamus to 1.6 ± 0.6 pmol/g in cerebellum. Chromatography of the extracts of human brain cortex, anterior hypothalamus, thalamus and amygdala on Sephadex G-50 disclosed one major peak which corresponded to the elution peak of synthetic somatostatin. Since the human brains were obtained at autopsy 11–36 h after death, the effects of temperature and time lapse between death and tissue extraction on SLI concentration and chromatographic pattern in rat brain were examined. After storage at 4°C or 23°C for 2 h and 8 h, a significant increase in SLI concentration was noted, although by 24 h the increase was no longer observed. A gradual loss in the earlier eluting forms of SLI on gel chromatography was observed with storage at 4°C or 23°C." @default.
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• W2060097706 date "1981-12-01" @default.
• W2060097706 modified "2023-09-28" @default.
• W2060097706 title "Regional distribution of somatostatin-like immunoreactivity in the human brain" @default.
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• W2060097706 doi "https://doi.org/10.1016/0006-8993(81)90743-5" @default.
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