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- W2060098434 abstract "A newly purified peptide from porcine intestine (PHI) was found to be a potent stimulant of the flow of pancreatic juice in anaesthetized turkeys (D50 75 ng/kg), and was about half as active as chicken vasoactive intestinal peptide (VIP, D50 47 ng/kg) to which it is structurally related. However, in anaesthetized rats, PHI, like VIP, was a weak stimulant of the flow of pancreatic juice. In contrast, porcine secretin, which is also structurally related to PHI, is a potent stimulant of the rat pancreas and a weak stimulant in birds. PHI had less than 0.01% immunochemical potency in a VIP radioimmunoassay. We conclude that PHI has VIP-like rather than secretin-like actions on the pancreas in birds and mammals; an avian counterpart of PHI could play a physiological role in the control of the exocrine pancreas." @default.
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- W2060098434 date "1980-11-01" @default.
- W2060098434 modified "2023-09-26" @default.
- W2060098434 title "Actions of a new peptide from porcine intestine (PHI) on pancreatic secretion in the rat and turkey" @default.
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- W2060098434 doi "https://doi.org/10.1016/0024-3205(80)90413-0" @default.
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