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- W2060106509 endingPage "1243" @default.
- W2060106509 startingPage "1230" @default.
- W2060106509 abstract "The antidepressant fluoxetine inhibits ceramide producing acid sphingomyelinase. Ceramide is in turn known to trigger eryptosis the suicidal death of erythrocytes characterized by cell shrinkage and exposure of phosphatidylserine at the erythrocyte surface. Ceramide is effective through sensitizing the erythrocytes to the pro-eryptotic effect of increased cytosolic Ca2+ activity ([Ca2+]i). In nucleated cells, fluoxetine could either inhibit or stimulate suicidal death or apoptosis. The present study tested whether fluoxetine influences eryptosis. To this end cell volume was estimated from forward scatter, phosphatidylserine exposure from annexin V binding, hemolysis from hemoglobin release and [Ca2+]i from Fluo-3 fluorescence intensity. As a result, a 48 h exposure of erythrocytes to fluoxetine (≥25 µM) significantly decreased forward scatter, increased annexin V binding and enhanced [Ca2+]i. The effect on annexin V binding was significantly blunted, but not abolished, in the absence of extracellular Ca2+. In conclusion, fluoxetine stimulates eryptosis, an effect at least in part due to increase of cytosolic Ca2+ activity." @default.
- W2060106509 created "2016-06-24" @default.
- W2060106509 creator A5004091570 @default.
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- W2060106509 creator A5046749073 @default.
- W2060106509 creator A5062621958 @default.
- W2060106509 creator A5084208566 @default.
- W2060106509 date "2013-07-15" @default.
- W2060106509 modified "2023-09-26" @default.
- W2060106509 title "Fluoxetine Induced Suicidal Erythrocyte Death" @default.
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