Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060111273> ?p ?o ?g. }
- W2060111273 endingPage "3441" @default.
- W2060111273 startingPage "3431" @default.
- W2060111273 abstract "Ptx1 (Pitx1) is a bicoid-related homeobox transcription factor expressed from the onset of pituitary development. It was shown to cooperate with cell-restricted factors, such as Pit1, NeuroD1/PanI and steroidogenic factor 1 (SF-1), to establish a combinatorial code conferring lineage- and promoter-specific gene transcription in the pituitary. Transcriptional synergism between Ptx1 and SF-1 on two SF-1 target genes, pituitary luteinizing hormone beta and Müllerian-inhibiting substance (MIS), requires SF-1 binding to DNA and appears to result from direct physical interaction between these two proteins. The interaction between the C-terminus of Ptx1 and the N-terminal half of SF-1 results in transcriptional enhancement that equals the activity of a constitutively active SF-1 mutant and that may mimic the effect of a still unidentified SF-1 ligand. Thus, the unmasking of SF-1 activity by Ptx1 may represent a developmental mechanism to alleviate the need for SF-1 ligand in transcription and, possibly, at critical times during organogenesis." @default.
- W2060111273 created "2016-06-24" @default.
- W2060111273 creator A5089185756 @default.
- W2060111273 date "1999-06-15" @default.
- W2060111273 modified "2023-10-18" @default.
- W2060111273 title "Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain" @default.
- W2060111273 cites W1230182988 @default.
- W2060111273 cites W142333331 @default.
- W2060111273 cites W1518173022 @default.
- W2060111273 cites W1798563091 @default.
- W2060111273 cites W1872961786 @default.
- W2060111273 cites W1923485297 @default.
- W2060111273 cites W1927347481 @default.
- W2060111273 cites W1967424239 @default.
- W2060111273 cites W1970473343 @default.
- W2060111273 cites W1971960644 @default.
- W2060111273 cites W1976306783 @default.
- W2060111273 cites W1977873240 @default.
- W2060111273 cites W1978969746 @default.
- W2060111273 cites W1983067877 @default.
- W2060111273 cites W1985473949 @default.
- W2060111273 cites W1988557430 @default.
- W2060111273 cites W1989429141 @default.
- W2060111273 cites W1990307219 @default.
- W2060111273 cites W1992520994 @default.
- W2060111273 cites W2002661794 @default.
- W2060111273 cites W2004275727 @default.
- W2060111273 cites W2005608222 @default.
- W2060111273 cites W2007795192 @default.
- W2060111273 cites W2011189608 @default.
- W2060111273 cites W2018216158 @default.
- W2060111273 cites W2028545666 @default.
- W2060111273 cites W2038591490 @default.
- W2060111273 cites W2038677555 @default.
- W2060111273 cites W2042122554 @default.
- W2060111273 cites W2046696024 @default.
- W2060111273 cites W2054736204 @default.
- W2060111273 cites W2055723072 @default.
- W2060111273 cites W2056362365 @default.
- W2060111273 cites W2058877341 @default.
- W2060111273 cites W2060021615 @default.
- W2060111273 cites W2066928256 @default.
- W2060111273 cites W2069510441 @default.
- W2060111273 cites W2072386144 @default.
- W2060111273 cites W2072604483 @default.
- W2060111273 cites W2078503449 @default.
- W2060111273 cites W2100859941 @default.
- W2060111273 cites W2102105685 @default.
- W2060111273 cites W2106468261 @default.
- W2060111273 cites W2107688352 @default.
- W2060111273 cites W2121959490 @default.
- W2060111273 cites W2131079238 @default.
- W2060111273 cites W2137366551 @default.
- W2060111273 cites W2139723733 @default.
- W2060111273 cites W2143150139 @default.
- W2060111273 cites W2147292969 @default.
- W2060111273 cites W2148438925 @default.
- W2060111273 cites W2150462237 @default.
- W2060111273 cites W2152023496 @default.
- W2060111273 cites W2156744272 @default.
- W2060111273 cites W2156827271 @default.
- W2060111273 cites W2157309735 @default.
- W2060111273 cites W2157392359 @default.
- W2060111273 cites W2166056427 @default.
- W2060111273 cites W2167963456 @default.
- W2060111273 cites W2171030691 @default.
- W2060111273 cites W2464733971 @default.
- W2060111273 doi "https://doi.org/10.1093/emboj/18.12.3431" @default.
- W2060111273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171422" @default.
- W2060111273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10369682" @default.
- W2060111273 hasPublicationYear "1999" @default.
- W2060111273 type Work @default.
- W2060111273 sameAs 2060111273 @default.
- W2060111273 citedByCount "129" @default.
- W2060111273 countsByYear W20601112732012 @default.
- W2060111273 countsByYear W20601112732013 @default.
- W2060111273 countsByYear W20601112732014 @default.
- W2060111273 countsByYear W20601112732015 @default.
- W2060111273 countsByYear W20601112732016 @default.
- W2060111273 countsByYear W20601112732017 @default.
- W2060111273 countsByYear W20601112732020 @default.
- W2060111273 crossrefType "journal-article" @default.
- W2060111273 hasAuthorship W2060111273A5089185756 @default.
- W2060111273 hasBestOaLocation W20601112731 @default.
- W2060111273 hasConcept C104317684 @default.
- W2060111273 hasConcept C121587040 @default.
- W2060111273 hasConcept C138885662 @default.
- W2060111273 hasConcept C143065580 @default.
- W2060111273 hasConcept C153911025 @default.
- W2060111273 hasConcept C179926584 @default.
- W2060111273 hasConcept C27153228 @default.
- W2060111273 hasConcept C2777703421 @default.
- W2060111273 hasConcept C41895202 @default.
- W2060111273 hasConcept C54355233 @default.
- W2060111273 hasConcept C63932345 @default.
- W2060111273 hasConcept C86339819 @default.
- W2060111273 hasConcept C86803240 @default.
- W2060111273 hasConcept C94966510 @default.