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- W2060129154 endingPage "e2745" @default.
- W2060129154 startingPage "e2745" @default.
- W2060129154 abstract "Background New interventions tools are a priority for schistosomiasis control and elimination, as the disease is still highly prevalent. The identification of proteins associated with active infection and protective immune response may constitute the basis for the development of a successful vaccine and could also indicate new diagnostic candidates. In this context, post-genomic technologies have been progressing, resulting in a more rational discovery of new biomarkers of resistance and antigens for diagnosis. Methodology/Principal Findings Two-dimensional electrophoresed Schistosoma mansoni adult worm protein extracts were probed with pooled sera of infected and non-infected (naturally resistant) individuals from a S. mansoni endemic area. A total of 47 different immunoreactive proteins were identified by mass spectrometry. Although the different pooled sera shared most of the immunoreactive protein spots, nine protein spots reacted exclusively with the serum pool of infected individuals, which correspond to annexin, major egg antigen, troponin T, filamin, disulphide-isomerase ER-60 precursor, actin and reticulocalbin. One protein spot, corresponding to eukaryotic translation elongation factor, reacted exclusively with the pooled sera of non-infected individuals living in the endemic area. Western blotting of two selected recombinant proteins, major egg antigen and hemoglobinase, showed a similar recognition pattern of that of the native protein. Concluding/Significance Using a serological proteome analysis, a group of antigens related to the different infection status of the endemic area residents was identified and may be related to susceptibility or resistance to infection." @default.
- W2060129154 created "2016-06-24" @default.
- W2060129154 creator A5011732165 @default.
- W2060129154 creator A5033071702 @default.
- W2060129154 creator A5048496084 @default.
- W2060129154 creator A5072160302 @default.
- W2060129154 creator A5076736965 @default.
- W2060129154 creator A5076974084 @default.
- W2060129154 creator A5079519238 @default.
- W2060129154 creator A5080779968 @default.
- W2060129154 creator A5081141400 @default.
- W2060129154 date "2014-03-20" @default.
- W2060129154 modified "2023-10-14" @default.
- W2060129154 title "Serological Screening of the Schistosoma mansoni Adult Worm Proteome" @default.
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