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• W2060139557 abstract "BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis. However, the exact mechanism by which BAG-1 inhibits apoptosis is unknown. In the current study, we comprehensively investigated BAG-1 mediated changes in gene expression by comparing the gene expression profile after BAG-1 siRNA silencing in the human lung adenocarcinoma cell line A549. Microarray assay revealed that expression of 589 genes was altered, including 177 upregulated and 412 downregulated genes. Real-time PCR assay of the changes in gene expression indicated a concordance of 86.48% (64/74) with that observed by microarray. The upregulated genes included EGFR, Jun, HSPA1A and CASP7, while the downregulated genes included Lyn, HRAS, and TGF-α. Furthermore, we confirmed by Western blot that the expression of EGFR, Jun, and HSPA1A were significantly increased, while expression of Lyn and HRAS were dramatically decreased after BAG-1 gene silencing. After transfection with BAG-1 siRNA, lung cancer cell lines A549 and L9981 exhibited significantly enhanced sensitivity to cisplatin-induced apoptosis. Thus, silencing of the BAG-1 gene resulted in changes in expression of apoptosis-related genes and sensitized A549 and L9981 cells to cisplatin-induced apoptosis." @default.
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• W2060139557 date "2010-05-15" @default.
• W2060139557 modified "2023-09-23" @default.
• W2060139557 title "Gene silencing of BAG-1 modulates apoptotic genes and sensitizes lung cancer cell lines to cisplatin-induced apoptosis" @default.
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• W2060139557 doi "https://doi.org/10.4161/cbt.9.10.11589" @default.
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• W2060139557 hasPublicationYear "2010" @default.
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