Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060141808> ?p ?o ?g. }
- W2060141808 endingPage "279" @default.
- W2060141808 startingPage "273" @default.
- W2060141808 abstract "High helium pressure of more than 2 MPa produces central neuroexcitatory motor behavior. In rodents, symptoms comprise locomotor and motor activity (LMA), myoclonia, and, at pressure greater than 9-10 MPa, convulsions and tonic-clonic seizures. We studied the behavioral effects of bilateral injection of the glutamate uptake inhibitor L-trans-pyrollidine-2,4-dicarboxylic acid (L-trans-PDC), in either the substantia nigra reticulata (SNr), the globus pallidus (GP), or the striatum on high helium pressure-induced LMA and myoclonia. Injection of L-trans-PDC in the GP and the SNr attenuated LMA, whereas injection in the striatum enhanced it. Alternatively, injection of L-trans-PDC in the SNr increased myoclonia, whereas injection in the GP or the striatum showed no effects on myoclonia. These results confirm that helium pressure-induced LMA and myoclonia have different neural origins. According to current thinking on basal ganglia function and previous data, it is suggested that high helium pressure would lead to a reduction of glutamate transmission in the SNr that could contribute to a reduction in activity of the nigrothalamic GABA pathway and then to the occurrence of LMA. It is further suggested that glutamate and DA transmissions in the striatum could have synergistic, rather than antagonistic, influences on motor activity." @default.
- W2060141808 created "2016-06-24" @default.
- W2060141808 creator A5050074385 @default.
- W2060141808 creator A5072879300 @default.
- W2060141808 creator A5075968525 @default.
- W2060141808 date "1999-12-01" @default.
- W2060141808 modified "2023-09-25" @default.
- W2060141808 title "Administration of the glutamate uptake inhibitor l-trans-PDC in the globus pallidus and the substantia nigra, but not in the striatum, attenuates the psychostimulant effect of high helium pressure on locomotor activity in the rat" @default.
- W2060141808 cites W1970569351 @default.
- W2060141808 cites W1977426021 @default.
- W2060141808 cites W1979937921 @default.
- W2060141808 cites W1983338277 @default.
- W2060141808 cites W1991300513 @default.
- W2060141808 cites W1992045034 @default.
- W2060141808 cites W2003465923 @default.
- W2060141808 cites W2004035808 @default.
- W2060141808 cites W2004951089 @default.
- W2060141808 cites W2006104436 @default.
- W2060141808 cites W2006952007 @default.
- W2060141808 cites W2010102500 @default.
- W2060141808 cites W2018242042 @default.
- W2060141808 cites W2023520518 @default.
- W2060141808 cites W2025125621 @default.
- W2060141808 cites W2025205835 @default.
- W2060141808 cites W2026347337 @default.
- W2060141808 cites W2030311149 @default.
- W2060141808 cites W2045350986 @default.
- W2060141808 cites W2046731705 @default.
- W2060141808 cites W2053904036 @default.
- W2060141808 cites W2055160986 @default.
- W2060141808 cites W2060255734 @default.
- W2060141808 cites W2060588252 @default.
- W2060141808 cites W2064473500 @default.
- W2060141808 cites W2065104855 @default.
- W2060141808 cites W2066093807 @default.
- W2060141808 cites W2069050766 @default.
- W2060141808 cites W2070435244 @default.
- W2060141808 cites W2077912746 @default.
- W2060141808 cites W2084639891 @default.
- W2060141808 cites W2085447577 @default.
- W2060141808 cites W2092290689 @default.
- W2060141808 cites W2093899264 @default.
- W2060141808 cites W2114116729 @default.
- W2060141808 cites W2129091202 @default.
- W2060141808 cites W2242042400 @default.
- W2060141808 cites W2344261471 @default.
- W2060141808 cites W2413448208 @default.
- W2060141808 cites W56637078 @default.
- W2060141808 cites W646277892 @default.
- W2060141808 doi "https://doi.org/10.1016/s0168-0102(99)00095-4" @default.
- W2060141808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10617318" @default.
- W2060141808 hasPublicationYear "1999" @default.
- W2060141808 type Work @default.
- W2060141808 sameAs 2060141808 @default.
- W2060141808 citedByCount "9" @default.
- W2060141808 countsByYear W20601418082012 @default.
- W2060141808 crossrefType "journal-article" @default.
- W2060141808 hasAuthorship W2060141808A5050074385 @default.
- W2060141808 hasAuthorship W2060141808A5072879300 @default.
- W2060141808 hasAuthorship W2060141808A5075968525 @default.
- W2060141808 hasConcept C126322002 @default.
- W2060141808 hasConcept C137183658 @default.
- W2060141808 hasConcept C169760540 @default.
- W2060141808 hasConcept C170493617 @default.
- W2060141808 hasConcept C185592680 @default.
- W2060141808 hasConcept C2778187257 @default.
- W2060141808 hasConcept C2780062018 @default.
- W2060141808 hasConcept C2780278869 @default.
- W2060141808 hasConcept C2780938664 @default.
- W2060141808 hasConcept C42219234 @default.
- W2060141808 hasConcept C513476851 @default.
- W2060141808 hasConcept C529278444 @default.
- W2060141808 hasConcept C55493867 @default.
- W2060141808 hasConcept C61174792 @default.
- W2060141808 hasConcept C71924100 @default.
- W2060141808 hasConcept C86803240 @default.
- W2060141808 hasConcept C98274493 @default.
- W2060141808 hasConceptScore W2060141808C126322002 @default.
- W2060141808 hasConceptScore W2060141808C137183658 @default.
- W2060141808 hasConceptScore W2060141808C169760540 @default.
- W2060141808 hasConceptScore W2060141808C170493617 @default.
- W2060141808 hasConceptScore W2060141808C185592680 @default.
- W2060141808 hasConceptScore W2060141808C2778187257 @default.
- W2060141808 hasConceptScore W2060141808C2780062018 @default.
- W2060141808 hasConceptScore W2060141808C2780278869 @default.
- W2060141808 hasConceptScore W2060141808C2780938664 @default.
- W2060141808 hasConceptScore W2060141808C42219234 @default.
- W2060141808 hasConceptScore W2060141808C513476851 @default.
- W2060141808 hasConceptScore W2060141808C529278444 @default.
- W2060141808 hasConceptScore W2060141808C55493867 @default.
- W2060141808 hasConceptScore W2060141808C61174792 @default.
- W2060141808 hasConceptScore W2060141808C71924100 @default.
- W2060141808 hasConceptScore W2060141808C86803240 @default.
- W2060141808 hasConceptScore W2060141808C98274493 @default.
- W2060141808 hasIssue "4" @default.
- W2060141808 hasLocation W20601418081 @default.
- W2060141808 hasLocation W20601418082 @default.
- W2060141808 hasOpenAccess W2060141808 @default.