Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060143133> ?p ?o ?g. }
- W2060143133 endingPage "1080" @default.
- W2060143133 startingPage "1076" @default.
- W2060143133 abstract "The novel peptidasome, called presequence protease, PreP, was originally identified and characterized in Arabidopsis thaliana as a mitochondrial matrix and chloroplast stroma localized metalloprotease. PreP has a function as the organellar peptide clearing protease and is responsible for degrading free targeting peptides and also other unstructured peptides up to 65 amino acid residues that might be toxic to organellar functions. PreP contains an inverted Zn-binding motif and belongs to the pitrilysin protease family. The crystal structure of AtPreP refined at 2.1 A demonstrated a unique totally enclosed large cavity of 10000 A3 that opens and closes in response to peptide binding, revealing a novel catalytic mechanism for proteolysis. Homologues of PreP have been found in yeast and human mitochondria. Interestingly, the human PreP, hPreP, is the protease that is responsible for clearing the human brain mitochondria from the toxic amyloid-beta peptide (Abeta) associated with Alzheimer's disease (AD). Accumulation of Abeta has been shown in the brain mitochondria from AD patients and mutant transgenic mice overexpressing Abeta. Here, we present a review of our present knowledge on structural and functional characteristics of PreP and discuss its mitochondrial Abeta-degrading activity in the human brain mitochondria in relation to AD." @default.
- W2060143133 created "2016-06-24" @default.
- W2060143133 creator A5012282638 @default.
- W2060143133 creator A5039571825 @default.
- W2060143133 date "2010-06-01" @default.
- W2060143133 modified "2023-10-13" @default.
- W2060143133 title "The organellar peptidasome, PreP: A journey from Arabidopsis to Alzheimer's disease" @default.
- W2060143133 cites W1498716467 @default.
- W2060143133 cites W1502266823 @default.
- W2060143133 cites W1755765541 @default.
- W2060143133 cites W1968257316 @default.
- W2060143133 cites W1969118834 @default.
- W2060143133 cites W1979252213 @default.
- W2060143133 cites W1980637648 @default.
- W2060143133 cites W1984785948 @default.
- W2060143133 cites W1988640203 @default.
- W2060143133 cites W2007136766 @default.
- W2060143133 cites W2007815419 @default.
- W2060143133 cites W2014612827 @default.
- W2060143133 cites W2015675204 @default.
- W2060143133 cites W2016436495 @default.
- W2060143133 cites W2023531011 @default.
- W2060143133 cites W2029152058 @default.
- W2060143133 cites W2033309752 @default.
- W2060143133 cites W2040076595 @default.
- W2060143133 cites W2046847750 @default.
- W2060143133 cites W2047841805 @default.
- W2060143133 cites W2048027386 @default.
- W2060143133 cites W2053684471 @default.
- W2060143133 cites W2060712542 @default.
- W2060143133 cites W2066799580 @default.
- W2060143133 cites W2071803058 @default.
- W2060143133 cites W2072453593 @default.
- W2060143133 cites W2076241970 @default.
- W2060143133 cites W2077307563 @default.
- W2060143133 cites W2093081526 @default.
- W2060143133 cites W2096457861 @default.
- W2060143133 cites W2097424323 @default.
- W2060143133 cites W2102476265 @default.
- W2060143133 cites W2103024032 @default.
- W2060143133 cites W2107947829 @default.
- W2060143133 cites W2111757377 @default.
- W2060143133 cites W2118782857 @default.
- W2060143133 cites W2121807639 @default.
- W2060143133 cites W2124097986 @default.
- W2060143133 cites W2124955411 @default.
- W2060143133 cites W2132988134 @default.
- W2060143133 cites W2133019124 @default.
- W2060143133 cites W2152165298 @default.
- W2060143133 cites W2163757074 @default.
- W2060143133 cites W2170398463 @default.
- W2060143133 cites W259119803 @default.
- W2060143133 cites W328114118 @default.
- W2060143133 doi "https://doi.org/10.1016/j.bbabio.2009.12.016" @default.
- W2060143133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20036633" @default.
- W2060143133 hasPublicationYear "2010" @default.
- W2060143133 type Work @default.
- W2060143133 sameAs 2060143133 @default.
- W2060143133 citedByCount "23" @default.
- W2060143133 countsByYear W20601431332012 @default.
- W2060143133 countsByYear W20601431332013 @default.
- W2060143133 countsByYear W20601431332014 @default.
- W2060143133 countsByYear W20601431332015 @default.
- W2060143133 countsByYear W20601431332019 @default.
- W2060143133 countsByYear W20601431332022 @default.
- W2060143133 crossrefType "journal-article" @default.
- W2060143133 hasAuthorship W2060143133A5012282638 @default.
- W2060143133 hasAuthorship W2060143133A5039571825 @default.
- W2060143133 hasBestOaLocation W20601431331 @default.
- W2060143133 hasConcept C104317684 @default.
- W2060143133 hasConcept C143065580 @default.
- W2060143133 hasConcept C181199279 @default.
- W2060143133 hasConcept C185592680 @default.
- W2060143133 hasConcept C2776714187 @default.
- W2060143133 hasConcept C2779281246 @default.
- W2060143133 hasConcept C2781307694 @default.
- W2060143133 hasConcept C28859421 @default.
- W2060143133 hasConcept C55493867 @default.
- W2060143133 hasConcept C86803240 @default.
- W2060143133 hasConcept C95444343 @default.
- W2060143133 hasConceptScore W2060143133C104317684 @default.
- W2060143133 hasConceptScore W2060143133C143065580 @default.
- W2060143133 hasConceptScore W2060143133C181199279 @default.
- W2060143133 hasConceptScore W2060143133C185592680 @default.
- W2060143133 hasConceptScore W2060143133C2776714187 @default.
- W2060143133 hasConceptScore W2060143133C2779281246 @default.
- W2060143133 hasConceptScore W2060143133C2781307694 @default.
- W2060143133 hasConceptScore W2060143133C28859421 @default.
- W2060143133 hasConceptScore W2060143133C55493867 @default.
- W2060143133 hasConceptScore W2060143133C86803240 @default.
- W2060143133 hasConceptScore W2060143133C95444343 @default.
- W2060143133 hasFunder F4320322581 @default.
- W2060143133 hasIssue "6-7" @default.
- W2060143133 hasLocation W20601431331 @default.
- W2060143133 hasLocation W20601431332 @default.
- W2060143133 hasOpenAccess W2060143133 @default.
- W2060143133 hasPrimaryLocation W20601431331 @default.
- W2060143133 hasRelatedWork W2155835698 @default.