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• W2060147007 abstract "You have accessJournal of UrologyProstate Cancer: Localized (I)1 Apr 2013364 IMPACT OF TREATMENT AND AGE ON QUALITY OF LIFE IN MEN UNDERGOING TREATMENT FOR PROSTATE CANCER Lindsay A. Hampson, Janet Cowan, Peter R. Carroll, and Matthew R. Cooperberg Lindsay A. HampsonLindsay A. Hampson San Francisco, CA More articles by this author , Janet CowanJanet Cowan San Francisco, CA More articles by this author , Peter R. CarrollPeter R. Carroll San Francisco, CA More articles by this author , and Matthew R. CooperbergMatthew R. Cooperberg San Francisco, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1751AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prostate cancer is the most common malignancy diagnosed in men, with a significant portion of new cases being diagnosed in men over the age of 65. We sought to describe quality of life (QOL) in men of all ages and evaluate the effect that treatment for prostate cancer has on their quality of life by age. METHODS Data were extracted from the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE). 3,354 patients in the analysis had localized disease and completed pre- and post-treatment quality of life assessments by the UCLA prostate cancer index (PCI) and the SF-36 survey. A clinically meaningful decline in QOL was defined as a decrease of at least half a standard deviation from pre- to 2 year post-treatment values. P-values <0.01 were considered statistically significant. RESULTS The percentage of patients who had a decline in QOL was highest for sexual function (56%), sexual bother (51%), and urinary function (50%), while a minority of patients noted worsening in urinary bother (30%), bowel function (24%), and bowel bother (24%). Only 17% and 21% of patients had a decline in physical function and mental health scores, respectively. Age at diagnosis was significantly associated with several QOL domains in logistic regression adjusted for diagnostic year, ethnicity, CAPRA clinical risk, and number of comorbid conditions at diagnosis as shown in Figure 1. Increasing age was associated with decline in urinary function in brachytherapy patients (OR 1.04 (95%CI 1.01-1.07)). Older RP patients were more likely to have declines in physical function (OR 1.05 (1.03-1.08)) and less likely to have worse sexual bother (OR 0.98 (0.96-0.99)). Older primary ADT patients were less likely to have worsening of urinary bother (OR 0.92 (0.86-0.97)) and sexual bother (OR 0.91 (0.86-0.97)). CONCLUSIONS Our data show that changes in quality of life after treatment for prostate cancer vary by age and treatment type. Increasing age is related to QOL outcomes at 2 years after treatment for some QOL measures. However, older patients do not necessarily experience the largest declines in QOL in all areas. These data provide valuable information to patients and physicians when considering treatment options. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e147 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lindsay A. Hampson San Francisco, CA More articles by this author Janet Cowan San Francisco, CA More articles by this author Peter R. Carroll San Francisco, CA More articles by this author Matthew R. Cooperberg San Francisco, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2060147007 title "364 IMPACT OF TREATMENT AND AGE ON QUALITY OF LIFE IN MEN UNDERGOING TREATMENT FOR PROSTATE CANCER" @default.
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