Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060147356> ?p ?o ?g. }
- W2060147356 endingPage "61" @default.
- W2060147356 startingPage "57" @default.
- W2060147356 abstract "Recent evidence suggests that chylomicron remnants (CMRs), the lipoproteins which carry dietary lipids in the blood, may play a direct role in the initiation of atherosclerosis by influencing vascular function. Unlike low-density lipoprotein (LDL), CMR do not require prior oxidation to bring about potentially pro-atherogenic effects on vascular endothelial cell function and macrophage foam cell formation. However, CMR carry oxidized lipids from the diet and may also become oxidized in the body, thus it is important to establish how the oxidative state of the particles may modulate these effects. Pharmacological studies have demonstrated that oxidation of CMR significantly enhances their inhibitory effects on endothelium-dependent vascular relaxation and their potentiation of vasoconstriction in rat and pig arteries. In striking contrast to the effects of LDL oxidation, however, the induction of macrophage foam cell formation has been found to be inversely related to the oxidative state of CMR. Thus, oxidation of CMR has potentially pro-atherogenic effects on endothelial function, but appears to protect against foam cell generation. These findings indicate that the oxidative state of CMR may cause important changes in the atherogenicity of the particles." @default.
- W2060147356 created "2016-06-24" @default.
- W2060147356 creator A5016695439 @default.
- W2060147356 date "2008-09-01" @default.
- W2060147356 modified "2023-10-16" @default.
- W2060147356 title "Oxidation of chylomicron remnants and vascular dysfunction" @default.
- W2060147356 cites W126725029 @default.
- W2060147356 cites W1841159787 @default.
- W2060147356 cites W1965466397 @default.
- W2060147356 cites W1974901538 @default.
- W2060147356 cites W1975249997 @default.
- W2060147356 cites W1978688068 @default.
- W2060147356 cites W1978812931 @default.
- W2060147356 cites W1989743926 @default.
- W2060147356 cites W1992746781 @default.
- W2060147356 cites W2000962675 @default.
- W2060147356 cites W2002001172 @default.
- W2060147356 cites W2009771141 @default.
- W2060147356 cites W2027484057 @default.
- W2060147356 cites W2032166112 @default.
- W2060147356 cites W2036865106 @default.
- W2060147356 cites W2064237759 @default.
- W2060147356 cites W2065306179 @default.
- W2060147356 cites W2068891547 @default.
- W2060147356 cites W2069028832 @default.
- W2060147356 cites W2080229257 @default.
- W2060147356 cites W2087519096 @default.
- W2060147356 cites W2093059833 @default.
- W2060147356 cites W2099791620 @default.
- W2060147356 cites W2105812305 @default.
- W2060147356 cites W2116999983 @default.
- W2060147356 cites W2158020124 @default.
- W2060147356 cites W2167013890 @default.
- W2060147356 cites W2170446129 @default.
- W2060147356 cites W2333369237 @default.
- W2060147356 cites W4232990100 @default.
- W2060147356 cites W4256391306 @default.
- W2060147356 doi "https://doi.org/10.1016/j.atherosclerosissup.2008.05.009" @default.
- W2060147356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18621590" @default.
- W2060147356 hasPublicationYear "2008" @default.
- W2060147356 type Work @default.
- W2060147356 sameAs 2060147356 @default.
- W2060147356 citedByCount "14" @default.
- W2060147356 countsByYear W20601473562012 @default.
- W2060147356 countsByYear W20601473562014 @default.
- W2060147356 countsByYear W20601473562015 @default.
- W2060147356 countsByYear W20601473562016 @default.
- W2060147356 countsByYear W20601473562019 @default.
- W2060147356 crossrefType "journal-article" @default.
- W2060147356 hasAuthorship W2060147356A5016695439 @default.
- W2060147356 hasBestOaLocation W20601473562 @default.
- W2060147356 hasConcept C11772777 @default.
- W2060147356 hasConcept C123012128 @default.
- W2060147356 hasConcept C126322002 @default.
- W2060147356 hasConcept C134018914 @default.
- W2060147356 hasConcept C185592680 @default.
- W2060147356 hasConcept C202751555 @default.
- W2060147356 hasConcept C2776992346 @default.
- W2060147356 hasConcept C2777895019 @default.
- W2060147356 hasConcept C2778004101 @default.
- W2060147356 hasConcept C2778163477 @default.
- W2060147356 hasConcept C2779244956 @default.
- W2060147356 hasConcept C2779961880 @default.
- W2060147356 hasConcept C2780072125 @default.
- W2060147356 hasConcept C2994476132 @default.
- W2060147356 hasConcept C55493867 @default.
- W2060147356 hasConcept C57600042 @default.
- W2060147356 hasConcept C71924100 @default.
- W2060147356 hasConcept C8243546 @default.
- W2060147356 hasConcept C86803240 @default.
- W2060147356 hasConcept C95444343 @default.
- W2060147356 hasConceptScore W2060147356C11772777 @default.
- W2060147356 hasConceptScore W2060147356C123012128 @default.
- W2060147356 hasConceptScore W2060147356C126322002 @default.
- W2060147356 hasConceptScore W2060147356C134018914 @default.
- W2060147356 hasConceptScore W2060147356C185592680 @default.
- W2060147356 hasConceptScore W2060147356C202751555 @default.
- W2060147356 hasConceptScore W2060147356C2776992346 @default.
- W2060147356 hasConceptScore W2060147356C2777895019 @default.
- W2060147356 hasConceptScore W2060147356C2778004101 @default.
- W2060147356 hasConceptScore W2060147356C2778163477 @default.
- W2060147356 hasConceptScore W2060147356C2779244956 @default.
- W2060147356 hasConceptScore W2060147356C2779961880 @default.
- W2060147356 hasConceptScore W2060147356C2780072125 @default.
- W2060147356 hasConceptScore W2060147356C2994476132 @default.
- W2060147356 hasConceptScore W2060147356C55493867 @default.
- W2060147356 hasConceptScore W2060147356C57600042 @default.
- W2060147356 hasConceptScore W2060147356C71924100 @default.
- W2060147356 hasConceptScore W2060147356C8243546 @default.
- W2060147356 hasConceptScore W2060147356C86803240 @default.
- W2060147356 hasConceptScore W2060147356C95444343 @default.
- W2060147356 hasIssue "2" @default.
- W2060147356 hasLocation W20601473561 @default.
- W2060147356 hasLocation W20601473562 @default.
- W2060147356 hasLocation W20601473563 @default.
- W2060147356 hasOpenAccess W2060147356 @default.
- W2060147356 hasPrimaryLocation W20601473561 @default.
- W2060147356 hasRelatedWork W1976602105 @default.