FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060147676> ?p ?o ?g. }

• W2060147676 endingPage "332" @default.
• W2060147676 startingPage "322" @default.
• W2060147676 abstract "Inflammatory processes can stimulate renal epithelial cells to release cytokines, chemoattractants and matrix proteins into the interstitium, thus contributing to interstitial injury during acute allograft rejection. To test the role of interleukin 17 (IL-17) in this process, cultured human renal epithelial cells (hRECs) were first established and treated with or without human IL-17 (hIL-17) for 2, 4, 8 and 10 h in vitro. Significant elevations of IL-6 and IL-8 levels were noted in the supernatants in a dose-dependent and time-dependent manner, as also for IL-6 mRNA expression. Secondly, using a rat acute allograft rejection model, the correlation between IL-17 expression and histopathological changes was serially studied. The results demonstrated that increased expression of IL-17 protein on infiltrating mononuclear cells (MNCs) was detectable on day 2. This corresponds to the borderline change of acute rejection according to the Banff classification, and it increased progressively to day 5. Serial study of IL-6, IL-8 and IL-17 mRNA expression of the renal allograft confirmed IL-17 mRNA expression in the allograft early on post-transplant day 2, whereas IL-6 and IL-8 expression started on day 3. Thirdly, IL-17 expression was observed in human renal allograft and urinary sediment. IL-17 protein expression was found in human subclinical (borderline) rejection renal allograft biopsy tissue and none in biopsy tissue not showing any evidence of rejection. There was also a 100% detectable rate of IL-17 mRNA expression in the MNCs of urinary sediment of patients with subclinical borderline rejection. These results demonstrate that hRECs exposed to IL-17 can produce inflammatory mediators with the potential to stimulate early alloimmune responses, which may also serve to give warning of acute renal allograft rejection." @default.
• W2060147676 created "2016-06-24" @default.
• W2060147676 creator A5000562074 @default.
• W2060147676 creator A5034387687 @default.
• W2060147676 creator A5059063515 @default.
• W2060147676 creator A5066929308 @default.
• W2060147676 creator A5085273267 @default.
• W2060147676 date "2002-04-16" @default.
• W2060147676 modified "2023-10-17" @default.
• W2060147676 title "<i>Retracted:</i>Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection" @default.
• W2060147676 cites W1543653831 @default.
• W2060147676 cites W1904996112 @default.
• W2060147676 cites W1911161962 @default.
• W2060147676 cites W1948195609 @default.
• W2060147676 cites W1976977140 @default.
• W2060147676 cites W1995791071 @default.
• W2060147676 cites W2000086986 @default.
• W2060147676 cites W2012974971 @default.
• W2060147676 cites W2013817592 @default.
• W2060147676 cites W2022383898 @default.
• W2060147676 cites W2022782025 @default.
• W2060147676 cites W2027443462 @default.
• W2060147676 cites W2033748051 @default.
• W2060147676 cites W2046369608 @default.
• W2060147676 cites W2055564572 @default.
• W2060147676 cites W2059727397 @default.
• W2060147676 cites W2074364259 @default.
• W2060147676 cites W2080005818 @default.
• W2060147676 cites W2158854771 @default.
• W2060147676 cites W2185221141 @default.
• W2060147676 cites W2462486598 @default.
• W2060147676 cites W4244540936 @default.
• W2060147676 cites W4313331748 @default.
• W2060147676 cites W4313333839 @default.
• W2060147676 cites W4321258628 @default.
• W2060147676 doi "https://doi.org/10.1002/path.1117" @default.
• W2060147676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12115878" @default.
• W2060147676 hasPublicationYear "2002" @default.
• W2060147676 type Work @default.
• W2060147676 sameAs 2060147676 @default.
• W2060147676 citedByCount "167" @default.
• W2060147676 countsByYear W20601476762012 @default.
• W2060147676 countsByYear W20601476762013 @default.
• W2060147676 countsByYear W20601476762014 @default.
• W2060147676 countsByYear W20601476762015 @default.
• W2060147676 countsByYear W20601476762016 @default.
• W2060147676 countsByYear W20601476762017 @default.
• W2060147676 countsByYear W20601476762018 @default.
• W2060147676 countsByYear W20601476762019 @default.
• W2060147676 countsByYear W20601476762020 @default.
• W2060147676 countsByYear W20601476762021 @default.
• W2060147676 countsByYear W20601476762022 @default.
• W2060147676 countsByYear W20601476762023 @default.
• W2060147676 crossrefType "journal-article" @default.
• W2060147676 hasAuthorship W2060147676A5000562074 @default.
• W2060147676 hasAuthorship W2060147676A5034387687 @default.
• W2060147676 hasAuthorship W2060147676A5059063515 @default.
• W2060147676 hasAuthorship W2060147676A5066929308 @default.
• W2060147676 hasAuthorship W2060147676A5085273267 @default.
• W2060147676 hasConcept C104317684 @default.
• W2060147676 hasConcept C105580179 @default.
• W2060147676 hasConcept C113280763 @default.
• W2060147676 hasConcept C126322002 @default.
• W2060147676 hasConcept C137061746 @default.
• W2060147676 hasConcept C142724271 @default.
• W2060147676 hasConcept C202751555 @default.
• W2060147676 hasConcept C203014093 @default.
• W2060147676 hasConcept C2775934546 @default.
• W2060147676 hasConcept C2778690821 @default.
• W2060147676 hasConcept C2781087799 @default.
• W2060147676 hasConcept C2911091166 @default.
• W2060147676 hasConcept C47348012 @default.
• W2060147676 hasConcept C55493867 @default.
• W2060147676 hasConcept C71924100 @default.
• W2060147676 hasConcept C74172505 @default.
• W2060147676 hasConcept C77411442 @default.
• W2060147676 hasConcept C86803240 @default.
• W2060147676 hasConcept C8891405 @default.
• W2060147676 hasConceptScore W2060147676C104317684 @default.
• W2060147676 hasConceptScore W2060147676C105580179 @default.
• W2060147676 hasConceptScore W2060147676C113280763 @default.
• W2060147676 hasConceptScore W2060147676C126322002 @default.
• W2060147676 hasConceptScore W2060147676C137061746 @default.
• W2060147676 hasConceptScore W2060147676C142724271 @default.
• W2060147676 hasConceptScore W2060147676C202751555 @default.
• W2060147676 hasConceptScore W2060147676C203014093 @default.
• W2060147676 hasConceptScore W2060147676C2775934546 @default.
• W2060147676 hasConceptScore W2060147676C2778690821 @default.
• W2060147676 hasConceptScore W2060147676C2781087799 @default.
• W2060147676 hasConceptScore W2060147676C2911091166 @default.
• W2060147676 hasConceptScore W2060147676C47348012 @default.
• W2060147676 hasConceptScore W2060147676C55493867 @default.
• W2060147676 hasConceptScore W2060147676C71924100 @default.
• W2060147676 hasConceptScore W2060147676C74172505 @default.
• W2060147676 hasConceptScore W2060147676C77411442 @default.
• W2060147676 hasConceptScore W2060147676C86803240 @default.
• W2060147676 hasConceptScore W2060147676C8891405 @default.
• W2060147676 hasFunder F4320327358 @default.

• next