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- W2060147785 abstract "Relapse has become the major cause of treatment failure after allogeneic hematopoietic stem cell transplantation. Outcome of patients with clinical relapse after transplantation generally remains poor, but intervention prior to florid relapse improves outcome for certain hematologic malignancies. To detect early relapse or minimal residual disease, sensitive methods such as molecular genetics, tumor-specific molecular primers, fluorescence in situ hybridization (FISH), and multiparameter flow cytometry (MFC) are commonly used after allogeneic stem cell transplantation to monitor patients, but not all of them are included in the commonly employed disease-specific response criteria. The highest sensitivity and specificity can be achieved by molecular monitoring of tumor- or patient-specific markers measured by polymerase chain reaction-based techniques, but not all diseases have such targets for monitoring. Similar high sensitivity can be achieved by determination of recipient-donor chimerism, but its specificity regarding detection of relapse is low and differs substantially among diseases. Here, we summarize the current knowledge about the utilization of such sensitive monitoring techniques in chronic leukemias, myeloproliferative neoplasms, and lymphoid malignancies based on tumor-specific markers and cell chimerism and how these methods might augment the standard definitions of posttransplant remission, persistence, progression, relapse, and the prediction of relapse. Critically important is the need for standardization of the different residual disease techniques and to assess the clinical relevance of minimal residual disease and chimerism surveillance in individual diseases, which in turn must be followed by studies to assess the potential impact of specific interventional strategies. Relapse has become the major cause of treatment failure after allogeneic hematopoietic stem cell transplantation. Outcome of patients with clinical relapse after transplantation generally remains poor, but intervention prior to florid relapse improves outcome for certain hematologic malignancies. To detect early relapse or minimal residual disease, sensitive methods such as molecular genetics, tumor-specific molecular primers, fluorescence in situ hybridization (FISH), and multiparameter flow cytometry (MFC) are commonly used after allogeneic stem cell transplantation to monitor patients, but not all of them are included in the commonly employed disease-specific response criteria. The highest sensitivity and specificity can be achieved by molecular monitoring of tumor- or patient-specific markers measured by polymerase chain reaction-based techniques, but not all diseases have such targets for monitoring. Similar high sensitivity can be achieved by determination of recipient-donor chimerism, but its specificity regarding detection of relapse is low and differs substantially among diseases. Here, we summarize the current knowledge about the utilization of such sensitive monitoring techniques in chronic leukemias, myeloproliferative neoplasms, and lymphoid malignancies based on tumor-specific markers and cell chimerism and how these methods might augment the standard definitions of posttransplant remission, persistence, progression, relapse, and the prediction of relapse. Critically important is the need for standardization of the different residual disease techniques and to assess the clinical relevance of minimal residual disease and chimerism surveillance in individual diseases, which in turn must be followed by studies to assess the potential impact of specific interventional strategies." @default.
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- W2060147785 date "2010-10-01" @default.
- W2060147785 modified "2023-10-18" @default.
- W2060147785 title "NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Disease-Specific Methods and Strategies for Monitoring Relapse Following Allogeneic Stem Cell Transplantation. Part II: Chronic Leukemias, Myeloproliferative Neoplasms, and Lymphoid Malignancies" @default.
- W2060147785 cites W1483173437 @default.
- W2060147785 cites W1511009642 @default.
- W2060147785 cites W1540355515 @default.
- W2060147785 cites W1589162162 @default.
- W2060147785 cites W1604672566 @default.
- W2060147785 cites W1754056873 @default.
- W2060147785 cites W1777438167 @default.
- W2060147785 cites W1914496726 @default.
- W2060147785 cites W1948519366 @default.
- W2060147785 cites W1966056550 @default.
- W2060147785 cites W1970476650 @default.
- W2060147785 cites W1973394001 @default.
- W2060147785 cites W1974451762 @default.
- W2060147785 cites W1975466309 @default.
- W2060147785 cites W1976851863 @default.
- W2060147785 cites W1977390830 @default.
- W2060147785 cites W1977950751 @default.
- W2060147785 cites W1978377409 @default.
- W2060147785 cites W1982415741 @default.
- W2060147785 cites W1982692505 @default.
- W2060147785 cites W1984585787 @default.
- W2060147785 cites W1985177017 @default.
- W2060147785 cites W1985600634 @default.
- W2060147785 cites W1987683792 @default.
- W2060147785 cites W1989188541 @default.
- W2060147785 cites W1990372450 @default.
- W2060147785 cites W1991644988 @default.
- W2060147785 cites W1994324689 @default.
- W2060147785 cites W2000676524 @default.
- W2060147785 cites W2001502135 @default.
- W2060147785 cites W2001965393 @default.
- W2060147785 cites W2004923784 @default.
- W2060147785 cites W2008182609 @default.
- W2060147785 cites W2010766702 @default.
- W2060147785 cites W2014443136 @default.
- W2060147785 cites W2016973656 @default.
- W2060147785 cites W2017073234 @default.
- W2060147785 cites W2017902684 @default.
- W2060147785 cites W2020094108 @default.
- W2060147785 cites W2020491471 @default.
- W2060147785 cites W2022682658 @default.
- W2060147785 cites W2022841233 @default.
- W2060147785 cites W2025691523 @default.
- W2060147785 cites W2032835397 @default.
- W2060147785 cites W2035375550 @default.
- W2060147785 cites W2037770288 @default.
- W2060147785 cites W2040040334 @default.
- W2060147785 cites W2040583441 @default.
- W2060147785 cites W2041811430 @default.
- W2060147785 cites W2041925366 @default.
- W2060147785 cites W2042714321 @default.
- W2060147785 cites W2044436186 @default.
- W2060147785 cites W2044696883 @default.
- W2060147785 cites W2045411075 @default.
- W2060147785 cites W2048333007 @default.
- W2060147785 cites W2050174398 @default.
- W2060147785 cites W2050281367 @default.
- W2060147785 cites W2052415602 @default.
- W2060147785 cites W2053750498 @default.
- W2060147785 cites W2054072333 @default.
- W2060147785 cites W2055925190 @default.
- W2060147785 cites W2057911436 @default.
- W2060147785 cites W2069586210 @default.
- W2060147785 cites W2071200397 @default.
- W2060147785 cites W2071741622 @default.
- W2060147785 cites W2071899049 @default.
- W2060147785 cites W2073060588 @default.
- W2060147785 cites W2074174622 @default.
- W2060147785 cites W2075706560 @default.
- W2060147785 cites W2076199422 @default.
- W2060147785 cites W2076584665 @default.
- W2060147785 cites W2079517811 @default.
- W2060147785 cites W2081251682 @default.
- W2060147785 cites W2085098635 @default.
- W2060147785 cites W2087843841 @default.
- W2060147785 cites W2088263025 @default.
- W2060147785 cites W2090911458 @default.