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- W2060147807 abstract "Cocaine can produce antinociception in a number of animal models. The present experiments were designed to determine if opioid receptor agonists modulate cocaine-induced antinociception in rats. Cocaine produced a dose-dependent increase in antinociception in the hot-plate, but not paw-pressure, test. The combination of cocaine and morphine or [D-Pen2, D-Pen5]enkephalin (DPDPE) produced results no greater than simple additivity in the hot-plate test. However, the combination of cocaine and morphine produced greater antinociception than morphine alone in the paw-pressure test. A low dose of U69,593 potentiated the effects of cocaine in the hot-plate test. In contrast, cocaine attenuated the effect of U69,593 in the paw-pressure test. Both naltrexone and the selective κ-opioid receptor antagonist nor-binaltorphamine (nor-BNI) blocked the potentiation of cocaine-induced antinociception by U69,593. The combination of U69,593 and cocaine can produce superadditive or subadditive effects, depending upon the doses and antinciceptive assay used." @default.
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- W2060147807 date "1999-02-01" @default.
- W2060147807 modified "2023-09-27" @default.
- W2060147807 title "Modulation of Cocaine-Induced Antinociception by Opioid-Receptor Agonists" @default.
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- W2060147807 doi "https://doi.org/10.1016/s0091-3057(98)00161-0" @default.
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