FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060162390> ?p ?o ?g. }

• W2060162390 abstract "Airway epithelial NF-kB activation is observed in asthmatic subjects and is a cause of airway inflammation in mouse models of allergic asthma. Combination therapy with inhaled short-acting b2-agonists and corticosteroids significantly improves lung function and reduces inflammation in asthmatic subjects. Corticosteroids operate through a number of mechanisms to potently inhibit NF-kB activity. Since b-agonists can induce expression of 11b-HSD1, which converts inactive 11-keto corticosteroids into active 11-hydroxy corticosteroids, thereby potentiating the effects of endogenous glucocorticoids, we examined whether this mechanism is involved in the inhibition of NF-kB activation induced by the b-agonist albuterol in airway epithelial cells. Treatment of transformed murine Club cells (MTCC) with (R)-albuterol (levalbuterol), but not with (S)- or a mixture of (R+S)- (racemic) albuterol, augmented mRNA expression of 11b-HSD1. MTCC were stably transfected with luciferase (luc) reporter constructs under transcriptional regulation by NF-kB (NF-kB/luc) or glucocorticoid response element (GRE/luc) consensus motifs. Stimulation of NF-kB/luc MTCC with lipopolysaccharide (LPS) or tumor necrosis factor-α (TNFα) induced luciferase activity, which was inhibited by pretreatment with (R)-, but not (S)- or racemic albuterol. Furthermore, pretreatment of GRE/luc MTCC with (R)-albuterol augmented 11-keto corticosteroid (cortisone) induced luciferase activity, which was diminished by the 11β-HSD inhibitor glycyrrhetinic acid (18β-GA). LPS- and TNFα-induced NF-kB/luc activity was diminished in MTCC cells treated with a combination of cortisone and (R)-albuterol, an effect that was inhibited by 18β-GA. Finally, pretreatment of MTCC cells with the combination of cortisone and (R)-albuterol diminished LPS- and TNFα-induced pro-inflammatory cytokine production. These results demonstrate that levalbuterol augments conversion of inactive 11-keto corticosteroids into the active 11-hydroxy form." @default.
• W2060162390 created "2016-06-24" @default.
• W2060162390 creator A5000180839 @default.
• W2060162390 creator A5029862853 @default.
• W2060162390 creator A5033875251 @default.
• W2060162390 creator A5063373290 @default.
• W2060162390 creator A5065900243 @default.
• W2060162390 creator A5068975754 @default.
• W2060162390 creator A5079684259 @default.
• W2060162390 date "2015-01-12" @default.
• W2060162390 modified "2023-09-26" @default.
• W2060162390 title "Anti-Inflammatory Effects of Levalbuterol-Induced 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Airway Epithelial Cells" @default.
• W2060162390 cites W1486583206 @default.
• W2060162390 cites W1605768991 @default.
• W2060162390 cites W1928868997 @default.
• W2060162390 cites W1958721249 @default.
• W2060162390 cites W1963709111 @default.
• W2060162390 cites W1967075652 @default.
• W2060162390 cites W1967959196 @default.
• W2060162390 cites W1969175500 @default.
• W2060162390 cites W1970717416 @default.
• W2060162390 cites W1976408380 @default.
• W2060162390 cites W1985236271 @default.
• W2060162390 cites W1991119065 @default.
• W2060162390 cites W1992521252 @default.
• W2060162390 cites W1993309780 @default.
• W2060162390 cites W1995257163 @default.
• W2060162390 cites W1997586209 @default.
• W2060162390 cites W2003109370 @default.
• W2060162390 cites W2010507765 @default.
• W2060162390 cites W2016125985 @default.
• W2060162390 cites W2019933043 @default.
• W2060162390 cites W2021711796 @default.
• W2060162390 cites W2022188895 @default.
• W2060162390 cites W2027455537 @default.
• W2060162390 cites W2030960902 @default.
• W2060162390 cites W2041115416 @default.
• W2060162390 cites W2052874934 @default.
• W2060162390 cites W2057335633 @default.
• W2060162390 cites W2059237923 @default.
• W2060162390 cites W2072451386 @default.
• W2060162390 cites W2072937570 @default.
• W2060162390 cites W2082985983 @default.
• W2060162390 cites W2083979379 @default.
• W2060162390 cites W2087098545 @default.
• W2060162390 cites W2090066423 @default.
• W2060162390 cites W2092184308 @default.
• W2060162390 cites W2093713190 @default.
• W2060162390 cites W2099876496 @default.
• W2060162390 cites W2101110303 @default.
• W2060162390 cites W2101664092 @default.
• W2060162390 cites W2108759223 @default.
• W2060162390 cites W2110708610 @default.
• W2060162390 cites W2114671974 @default.
• W2060162390 cites W2116097770 @default.
• W2060162390 cites W2125966954 @default.
• W2060162390 cites W2144944593 @default.
• W2060162390 cites W2148930555 @default.
• W2060162390 cites W2153236387 @default.
• W2060162390 cites W2153965794 @default.
• W2060162390 cites W2157487693 @default.
• W2060162390 cites W2157902472 @default.
• W2060162390 cites W2161938158 @default.
• W2060162390 cites W2164549076 @default.
• W2060162390 cites W2176025269 @default.
• W2060162390 cites W2185196942 @default.
• W2060162390 cites W223433465 @default.
• W2060162390 cites W2412329568 @default.
• W2060162390 cites W4234347340 @default.
• W2060162390 cites W4235755338 @default.
• W2060162390 cites W4239218095 @default.
• W2060162390 cites W4252967859 @default.
• W2060162390 doi "https://doi.org/10.3389/fendo.2014.00236" @default.
• W2060162390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4290686" @default.
• W2060162390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25628603" @default.
• W2060162390 hasPublicationYear "2015" @default.
• W2060162390 type Work @default.
• W2060162390 sameAs 2060162390 @default.
• W2060162390 citedByCount "4" @default.
• W2060162390 countsByYear W20601623902017 @default.
• W2060162390 countsByYear W20601623902022 @default.
• W2060162390 countsByYear W20601623902023 @default.
• W2060162390 crossrefType "journal-article" @default.
• W2060162390 hasAuthorship W2060162390A5000180839 @default.
• W2060162390 hasAuthorship W2060162390A5029862853 @default.
• W2060162390 hasAuthorship W2060162390A5033875251 @default.
• W2060162390 hasAuthorship W2060162390A5063373290 @default.
• W2060162390 hasAuthorship W2060162390A5065900243 @default.
• W2060162390 hasAuthorship W2060162390A5068975754 @default.
• W2060162390 hasAuthorship W2060162390A5079684259 @default.
• W2060162390 hasBestOaLocation W20601623901 @default.
• W2060162390 hasConcept C104317684 @default.
• W2060162390 hasConcept C111335760 @default.
• W2060162390 hasConcept C126322002 @default.
• W2060162390 hasConcept C134018914 @default.
• W2060162390 hasConcept C164027704 @default.
• W2060162390 hasConcept C166075782 @default.
• W2060162390 hasConcept C170493617 @default.
• W2060162390 hasConcept C17991360 @default.
• W2060162390 hasConcept C181199279 @default.

• next