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• W2060175990 abstract "The ability of surgeons to accelerate wound healing through pharmacologic intervention is limited. The effects of locally applied, biosynthetic human epidermal growth factor (EGF) and transforming growth factor-beta (TGF-β) on tensile strength of experimental incisions were investigated. A single dose of EGF in saline failed to increase tensile strength over controls. Thus, EGF was incorporated into multilamellar liposomes, which prolonged the exposure of incisions to EGF (p < 0.001). A single dose of EGF in multilamellar liposomes produced a 200% increase in wound tensile strength over controls between 7 and 14 days (p < 0.05). Light and electron microscopy of the wounds revealed increased collagen formation and fibroblast proliferation. A single dose of TGB-β in a collagen vehicle stimulated a 51% increase in wound tensile strength at 9 days (p < 0.01). We conclude that addition of EGF and TGF-β in appropriate vehicles stimulates early transient increases in wound tensile strength in normal rats." @default.
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• W2060175990 date "1988-12-01" @default.
• W2060175990 modified "2023-10-11" @default.
• W2060175990 title "Acceleration of Tensile Strength of Incisions Treated with EGF and TGF-β" @default.
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• W2060175990 doi "https://doi.org/10.1097/00000658-198812000-00019" @default.
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