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- W2060178425 endingPage "2599" @default.
- W2060178425 startingPage "2590" @default.
- W2060178425 abstract "TP53 belongs to a small gene family that includes, in mammals, two additional paralogs, TP63 and TP73. The p63 and p73 proteins are structurally and functionally similar to p53 and their activity as transcription factors is regulated by a wide repertoire of shared and unique post-translational modifications and interactions with regulatory cofactors. p63 and p73 have important functions in embryonic development and differentiation but are also involved in tumor suppression. The biology of p63 and p73 is complex since both TP63 and TP73 genes are transcribed into a variety of different isoforms that give rise to proteins with antagonistic properties, the TA-isoforms that act as tumor-suppressors and DN-isoforms that behave as proto-oncogenes. The p53 family as a whole behaves as a signaling network that integrates developmental, metabolic and stress signals to control cell metabolism, differentiation, longevity, proliferation and death. Despite the progress of our knowledge, the unresolved puzzle of complexity, redundancy and hierarchy in the p53 family continues to represent a formidable challenge." @default.
- W2060178425 created "2016-06-24" @default.
- W2060178425 creator A5000431817 @default.
- W2060178425 creator A5024653835 @default.
- W2060178425 creator A5037397426 @default.
- W2060178425 creator A5053176930 @default.
- W2060178425 creator A5064563908 @default.
- W2060178425 creator A5067064486 @default.
- W2060178425 creator A5082265951 @default.
- W2060178425 creator A5085697674 @default.
- W2060178425 date "2014-06-28" @default.
- W2060178425 modified "2023-09-27" @default.
- W2060178425 title "<i>TP63</i>and<i>TP73</i>in cancer, an unresolved “family” puzzle of complexity, redundancy and hierarchy" @default.
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