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- W2060180962 abstract "Abstract The clinical efficacy of lithium to prophylactically reduce profound mood cycling inpatients with bipolar disorder is indicative of its ability to stabilize the underlying disease mechanism(s). Chronic lithium may exert its therapeutic effects by normalizing aberrant phosphoinositide signaling through its interactions with the phosphoinositide pathway and down-stream alterations in protein kinase C (PKC) activity and substrate phosphorylation. We have shown that chronic, but not acute, lithium treatment at clinically relevant concentrations significantly reduces the expression of MARCKS (myristoylated alanine rich C-kinase substrate), a primary and preferential PKC substrate, and that MARCKS gene expression is regulated by chronic lithium at the transcriptional level through a lithium-responsive element in the MARCKS promoter. The MARCKS protein is located in pre- and postsynaptic terminals where it has been implicated to regulate phosphoinositide hydrolysis, filamentous-actin cytoskeletal plasticity, vesicular trafficking and the release efficacy of several neurotransmitters. MARCKS is necessary for normal mouse brain development, and remains highly expressed in several key adult cortical, limbic, and subcortical brain regions. Several neuroplastic events are sensitive to alterations in MARCKS expression, and prolonged elevations in PKC activity, physiological stress, and proinflammatory factors induce alterations in MARCKS expression. The long-term mood-stabilizing effect, as well as some side-effects (memory impairment), of chronic lithium may stem from its capacity to down-regulate MARCKS expression and/or phosphorylation in dysregulated circuits of key brain regions." @default.
- W2060180962 created "2016-06-24" @default.
- W2060180962 creator A5061204435 @default.
- W2060180962 creator A5091032668 @default.
- W2060180962 date "2004-12-01" @default.
- W2060180962 modified "2023-10-13" @default.
- W2060180962 title "The myristoylated alanine-rich C kinase substrate: a lithium-regulated protein linking cellular signaling and cytoskeletal plasticity" @default.
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