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- W2060186899 abstract "We conducted bioassay experiments to determine whether nitric oxide produced by endothelial cells (endothelial-derived nitric oxide, or EDNO) within large venules could act to dilate arterioles.In these experiments parallel segments of first-order arterioles and venules were isolated from skeletal muscle and were cannulated in series with a glass connecting tube (length: 300-500 microns). Arterioles were mechanically denuded of endothelium by a delicate yet abrasive rubbing technique. Venular endothelium remained intact. Endothelial denudation of arterioles was confirmed by the absence of dilation during exposure to acetylcholine (10(-6) mol/L). The cannulated vessels were pressurized to 30 cm H2O and the arterioles pre-constricted by approximately 50% with norepinephrine (10(-10) mol/L).Topical applications of acetylcholine (10(-6) mol/L) or bradykinin (10(-9) mol/L) during luminal perfusion from venule to arteriole produced significant arteriolar dilation. In contrast, a slight arteriolar constriction was observed when the direction of flow was reversed (i.e., arteriole to venule) in the presence of either acetylcholine (10(-6) mol/L) or bradykinin (10(-9) mol/L). Inhibition of venular EDNO with NG-monomethyl-L-arginine (L-NMMA; 10(-5) mol/L; 1 hour) completely abolished the arteriolar dilation observed in response to acetylcholine or bradykinin during venule to arteriole perfusion.These results demonstrate that venular-derived EDNO can relax arteriolar vascular smooth muscle." @default.
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- W2060186899 date "1997-01-01" @default.
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- W2060186899 title "Arteriolar Dilation Produced by Venule Endothelium-Derived Nitric Oxide" @default.
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- W2060186899 doi "https://doi.org/10.3109/10739689709146793" @default.
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