FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060191723> ?p ?o ?g. }

• W2060191723 endingPage "264" @default.
• W2060191723 startingPage "255" @default.
• W2060191723 abstract "As part of our effort to study the role of reactive species in amyotrophic lateral sclerosis (ALS), the goal of this work is to explore the correlation between nitration and oxidation of proteins and mutation of Cu, Zn-superoxide dismutase (SOD1) in ALS. Transgenic mice overexpressing the mutant Cu, Zn-superoxide dismutase (mSOD1) gene from humans with familial ALS, wild-type mice overexpressing the normal human SOD1 gene and normal mice without gene overexpression were used. Brain sections from different regions of three groups of mice were double immunohistochemically stained with anti-neurofilament plus anti-nitrotyrosine or treated with 2,4-dinitrophenylhydrazine to label protein carbonyls, then double stained with anti-neurofilament plus anti-2,4-dinitrophenyl (anti-DNP). Neurons containing nitrated and oxidized proteins were visualized only in mSOD1 mice in the motor cortex, the cerebellar cortex and nucleus of hypoglossal nerves (regions related with movement). This correlates mutation of SOD1 to nitration and oxidation of neurons in the movement regions. By counting double-stained neurons, we demonstrated that the number of nitrotyrosine- and DNP-positive neurons was significantly higher in the brain sections of both motor and sensory cortex in mSOD1 mice than in the corresponding regions of control mice (P=0.005 to <0.001), further correlating nitration and oxidation of proteins to SOD1 mutation. Neurons underwent significantly more nitration and oxidation in the motor cortex than in the sensory cortex in mSOD1 mice (P=0.002 and 0.02 respectively), indicating enhanced susceptibility of the motor cortex to nitration and oxidation of proteins and thereby targeting oxidation and nitration of proteins in neurons of the motor cortex in ALS. Significantly elevated protein nitration and nitric oxide synthesis were also demonstrated biochemically in the brain tissues and in cerebrospinal fluid of mutant SOD1 mice. Our in vivo evidence correlates mutation of the SOD1 gene to increased nitric oxide, nitration and oxidation of proteins in ALS." @default.
• W2060191723 created "2016-06-24" @default.
• W2060191723 creator A5060409592 @default.
• W2060191723 creator A5083368899 @default.
• W2060191723 creator A5085503597 @default.
• W2060191723 creator A5091510217 @default.
• W2060191723 date "2007-04-01" @default.
• W2060191723 modified "2023-09-30" @default.
• W2060191723 title "Mutation of superoxide dismutase elevates reactive species: Comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis" @default.
• W2060191723 cites W1567614586 @default.
• W2060191723 cites W1585029221 @default.
• W2060191723 cites W1704536892 @default.
• W2060191723 cites W1722754210 @default.
• W2060191723 cites W1729930119 @default.
• W2060191723 cites W1872376120 @default.
• W2060191723 cites W1972406722 @default.
• W2060191723 cites W1975377124 @default.
• W2060191723 cites W1977069725 @default.
• W2060191723 cites W1977368803 @default.
• W2060191723 cites W1979180383 @default.
• W2060191723 cites W1982054375 @default.
• W2060191723 cites W1982167643 @default.
• W2060191723 cites W1988931872 @default.
• W2060191723 cites W1992229482 @default.
• W2060191723 cites W1998702457 @default.
• W2060191723 cites W1999649376 @default.
• W2060191723 cites W2008012309 @default.
• W2060191723 cites W2009125386 @default.
• W2060191723 cites W2011766911 @default.
• W2060191723 cites W2020914812 @default.
• W2060191723 cites W2023105087 @default.
• W2060191723 cites W2027080145 @default.
• W2060191723 cites W2027154982 @default.
• W2060191723 cites W2028697552 @default.
• W2060191723 cites W2029807159 @default.
• W2060191723 cites W2030654136 @default.
• W2060191723 cites W2038443620 @default.
• W2060191723 cites W2042308433 @default.
• W2060191723 cites W2047532953 @default.
• W2060191723 cites W2051587560 @default.
• W2060191723 cites W2053040219 @default.
• W2060191723 cites W2056123940 @default.
• W2060191723 cites W2058853472 @default.
• W2060191723 cites W2058977770 @default.
• W2060191723 cites W2059640915 @default.
• W2060191723 cites W2062384458 @default.
• W2060191723 cites W2063046332 @default.
• W2060191723 cites W2065541571 @default.
• W2060191723 cites W2068201081 @default.
• W2060191723 cites W2071921711 @default.
• W2060191723 cites W2074302310 @default.
• W2060191723 cites W2080228411 @default.
• W2060191723 cites W2081457844 @default.
• W2060191723 cites W2081879241 @default.
• W2060191723 cites W2087131420 @default.
• W2060191723 cites W2089456608 @default.
• W2060191723 cites W2096386031 @default.
• W2060191723 cites W2101056451 @default.
• W2060191723 cites W2102418949 @default.
• W2060191723 cites W2107768418 @default.
• W2060191723 cites W2132747770 @default.
• W2060191723 cites W2133164753 @default.
• W2060191723 cites W2137434543 @default.
• W2060191723 cites W2166155593 @default.
• W2060191723 cites W2316918019 @default.
• W2060191723 doi "https://doi.org/10.1016/j.neuroscience.2007.01.028" @default.
• W2060191723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17368952" @default.
• W2060191723 hasPublicationYear "2007" @default.
• W2060191723 type Work @default.
• W2060191723 sameAs 2060191723 @default.
• W2060191723 citedByCount "37" @default.
• W2060191723 countsByYear W20601917232012 @default.
• W2060191723 countsByYear W20601917232013 @default.
• W2060191723 countsByYear W20601917232014 @default.
• W2060191723 countsByYear W20601917232015 @default.
• W2060191723 countsByYear W20601917232016 @default.
• W2060191723 countsByYear W20601917232018 @default.
• W2060191723 countsByYear W20601917232019 @default.
• W2060191723 countsByYear W20601917232020 @default.
• W2060191723 crossrefType "journal-article" @default.
• W2060191723 hasAuthorship W2060191723A5060409592 @default.
• W2060191723 hasAuthorship W2060191723A5083368899 @default.
• W2060191723 hasAuthorship W2060191723A5085503597 @default.
• W2060191723 hasAuthorship W2060191723A5091510217 @default.
• W2060191723 hasConcept C102230213 @default.
• W2060191723 hasConcept C104317684 @default.
• W2060191723 hasConcept C141035611 @default.
• W2060191723 hasConcept C142724271 @default.
• W2060191723 hasConcept C153911025 @default.
• W2060191723 hasConcept C157207234 @default.
• W2060191723 hasConcept C169760540 @default.
• W2060191723 hasConcept C181199279 @default.
• W2060191723 hasConcept C185592680 @default.
• W2060191723 hasConcept C203014093 @default.
• W2060191723 hasConcept C204232928 @default.
• W2060191723 hasConcept C24998067 @default.
• W2060191723 hasConcept C2775838275 @default.
• W2060191723 hasConcept C2776151105 @default.

• next