Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060192637> ?p ?o ?g. }
- W2060192637 endingPage "12" @default.
- W2060192637 startingPage "1" @default.
- W2060192637 abstract "An industrial mutant of Streptomyces avermitilis produced avermectin at a high level in industrial complex culture medium. However, almost no avermectin was detected in the cultures of tryptone soya broth (TSB). Its wild-type strain could not synthesize avermectin. To elucidate the regulatory mechanism about avermectin production, proteomic analysis of S. avermitilis was carried out. Results showed that during avermectin biosynthesis, fatty acid metabolism and TCA cycle were repressed. Partial enrichment of glycolytic pathway indicated the critical role of glucose catabolism during avermectin biosynthesis. Some enriched enzymes in amino acid metabolic pathways (glnA, leuC) confirmed the leucine as the possible precursor of avermectin. Highly expressed stress or stress-related proteins indicated a global regulation mechanism at the onset of avermectin production. And highly expressed morphology control proteins revealed an association between hyphal morphology and avermectin production. Further, this study proofed strengthened capability to utilize carbon and nitrogen source in the industrial strain. Some stress or stress-related proteins (eshA, clpC, dnaK and grpE) expressed at low level in the industrial strain cultivated in non-production medium (lower than that in the wild-type strain), but these highly expressed at the onset of avermectin production. More sensible response to environmental stress may be responsible for it." @default.
- W2060192637 created "2016-06-24" @default.
- W2060192637 creator A5015550137 @default.
- W2060192637 creator A5016610139 @default.
- W2060192637 creator A5023117208 @default.
- W2060192637 creator A5042661279 @default.
- W2060192637 creator A5053551556 @default.
- W2060192637 creator A5057257864 @default.
- W2060192637 creator A5068396172 @default.
- W2060192637 creator A5070877846 @default.
- W2060192637 date "2013-02-01" @default.
- W2060192637 modified "2023-09-24" @default.
- W2060192637 title "Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production" @default.
- W2060192637 cites W1539580523 @default.
- W2060192637 cites W1865301229 @default.
- W2060192637 cites W1965481000 @default.
- W2060192637 cites W1969307731 @default.
- W2060192637 cites W1971784484 @default.
- W2060192637 cites W1975990801 @default.
- W2060192637 cites W1985388258 @default.
- W2060192637 cites W1991297887 @default.
- W2060192637 cites W1999838562 @default.
- W2060192637 cites W2001176819 @default.
- W2060192637 cites W2002821863 @default.
- W2060192637 cites W2014063695 @default.
- W2060192637 cites W2015732856 @default.
- W2060192637 cites W2021040301 @default.
- W2060192637 cites W2030731091 @default.
- W2060192637 cites W2030958510 @default.
- W2060192637 cites W2037767853 @default.
- W2060192637 cites W2045765725 @default.
- W2060192637 cites W2050444575 @default.
- W2060192637 cites W2051228317 @default.
- W2060192637 cites W2051793369 @default.
- W2060192637 cites W2053827071 @default.
- W2060192637 cites W2067128865 @default.
- W2060192637 cites W2067362549 @default.
- W2060192637 cites W2070672282 @default.
- W2060192637 cites W2072744250 @default.
- W2060192637 cites W2073553628 @default.
- W2060192637 cites W2081418090 @default.
- W2060192637 cites W2090719646 @default.
- W2060192637 cites W2091296476 @default.
- W2060192637 cites W2092227366 @default.
- W2060192637 cites W2092876690 @default.
- W2060192637 cites W2119999468 @default.
- W2060192637 cites W2123737628 @default.
- W2060192637 cites W2127478915 @default.
- W2060192637 cites W2141724213 @default.
- W2060192637 cites W2144214902 @default.
- W2060192637 cites W2150904764 @default.
- W2060192637 cites W2161574105 @default.
- W2060192637 cites W278895513 @default.
- W2060192637 cites W4293247451 @default.
- W2060192637 doi "https://doi.org/10.1016/j.jprot.2012.11.012" @default.
- W2060192637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23201115" @default.
- W2060192637 hasPublicationYear "2013" @default.
- W2060192637 type Work @default.
- W2060192637 sameAs 2060192637 @default.
- W2060192637 citedByCount "9" @default.
- W2060192637 countsByYear W20601926372014 @default.
- W2060192637 countsByYear W20601926372016 @default.
- W2060192637 countsByYear W20601926372017 @default.
- W2060192637 countsByYear W20601926372020 @default.
- W2060192637 countsByYear W20601926372022 @default.
- W2060192637 crossrefType "journal-article" @default.
- W2060192637 hasAuthorship W2060192637A5015550137 @default.
- W2060192637 hasAuthorship W2060192637A5016610139 @default.
- W2060192637 hasAuthorship W2060192637A5023117208 @default.
- W2060192637 hasAuthorship W2060192637A5042661279 @default.
- W2060192637 hasAuthorship W2060192637A5053551556 @default.
- W2060192637 hasAuthorship W2060192637A5057257864 @default.
- W2060192637 hasAuthorship W2060192637A5068396172 @default.
- W2060192637 hasAuthorship W2060192637A5070877846 @default.
- W2060192637 hasConcept C105702510 @default.
- W2060192637 hasConcept C185592680 @default.
- W2060192637 hasConcept C2777818436 @default.
- W2060192637 hasConcept C2778022156 @default.
- W2060192637 hasConcept C2779920670 @default.
- W2060192637 hasConcept C2780535491 @default.
- W2060192637 hasConcept C523546767 @default.
- W2060192637 hasConcept C54355233 @default.
- W2060192637 hasConcept C55493867 @default.
- W2060192637 hasConcept C86803240 @default.
- W2060192637 hasConceptScore W2060192637C105702510 @default.
- W2060192637 hasConceptScore W2060192637C185592680 @default.
- W2060192637 hasConceptScore W2060192637C2777818436 @default.
- W2060192637 hasConceptScore W2060192637C2778022156 @default.
- W2060192637 hasConceptScore W2060192637C2779920670 @default.
- W2060192637 hasConceptScore W2060192637C2780535491 @default.
- W2060192637 hasConceptScore W2060192637C523546767 @default.
- W2060192637 hasConceptScore W2060192637C54355233 @default.
- W2060192637 hasConceptScore W2060192637C55493867 @default.
- W2060192637 hasConceptScore W2060192637C86803240 @default.
- W2060192637 hasFunder F4320321001 @default.
- W2060192637 hasLocation W20601926371 @default.
- W2060192637 hasLocation W20601926372 @default.
- W2060192637 hasOpenAccess W2060192637 @default.