Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060196721> ?p ?o ?g. }
- W2060196721 endingPage "674" @default.
- W2060196721 startingPage "661" @default.
- W2060196721 abstract "Evidence suggests that the neural cell adhesion molecule (NCAM) is an important molecular constituent of adaptive and maladaptive circuit (re-)organization in the central nervous system. Here, we further investigate its putative involvement in amygdala and hippocampus functions during context fear memory formation. Using laser capture microdissection and quantitative RT-PCR, we show high NCAM mRNA expression levels in the lateral and basolateral subnuclei of the amygdala, as well as their training intensity- and context-dependent regulation during fear memory consolidation. Moreover, we demonstrate that deficits of NCAM-/- mice in context fear memory can be overcome through contextual pre-exposure, i.e. by reducing the modulatory influence of the amygdala on this hippocampus-dependent memory. On the contrary, NCAM-/- mice failed to increase contextual fear memory after salient overtraining, although they adequately increased their response to auditory-cued fear stimuli. Finally, we demonstrate a reduction of amygdalo-hippocampal theta synchronization in NCAM-/- mice during fear memory retrieval. Together, these results suggest an involvement of NCAM-mediated cell recognition processes in information processing of the amygdalo-hippocampal system and in the amygdala-mediated modulation of context fear memory according to stimulus salience." @default.
- W2060196721 created "2016-06-24" @default.
- W2060196721 creator A5018709602 @default.
- W2060196721 creator A5023323655 @default.
- W2060196721 creator A5067258427 @default.
- W2060196721 creator A5079620447 @default.
- W2060196721 date "2010-06-01" @default.
- W2060196721 modified "2023-10-18" @default.
- W2060196721 title "Role of the neural cell adhesion molecule (NCAM) in amygdalo-hippocampal interactions and salience determination of contextual fear memory" @default.
- W2060196721 cites W1583583812 @default.
- W2060196721 cites W1591353378 @default.
- W2060196721 cites W1601515225 @default.
- W2060196721 cites W1938841438 @default.
- W2060196721 cites W1963727074 @default.
- W2060196721 cites W1967887989 @default.
- W2060196721 cites W1973879284 @default.
- W2060196721 cites W1981495948 @default.
- W2060196721 cites W1989444063 @default.
- W2060196721 cites W1993364340 @default.
- W2060196721 cites W1997679949 @default.
- W2060196721 cites W1999086457 @default.
- W2060196721 cites W2007687184 @default.
- W2060196721 cites W2008326600 @default.
- W2060196721 cites W2009646296 @default.
- W2060196721 cites W2015067996 @default.
- W2060196721 cites W2015887503 @default.
- W2060196721 cites W2019297908 @default.
- W2060196721 cites W2020004640 @default.
- W2060196721 cites W2022880028 @default.
- W2060196721 cites W2026144668 @default.
- W2060196721 cites W2027120715 @default.
- W2060196721 cites W2029931657 @default.
- W2060196721 cites W2031471928 @default.
- W2060196721 cites W2035626388 @default.
- W2060196721 cites W2036642338 @default.
- W2060196721 cites W2037237842 @default.
- W2060196721 cites W2037877714 @default.
- W2060196721 cites W2040558271 @default.
- W2060196721 cites W2041613013 @default.
- W2060196721 cites W2051791863 @default.
- W2060196721 cites W2055772777 @default.
- W2060196721 cites W2057072761 @default.
- W2060196721 cites W2062476270 @default.
- W2060196721 cites W2065716997 @default.
- W2060196721 cites W2069142370 @default.
- W2060196721 cites W2072971762 @default.
- W2060196721 cites W2073030545 @default.
- W2060196721 cites W2076813149 @default.
- W2060196721 cites W2078522497 @default.
- W2060196721 cites W2085339001 @default.
- W2060196721 cites W2095154551 @default.
- W2060196721 cites W2102291779 @default.
- W2060196721 cites W2103084807 @default.
- W2060196721 cites W2107277218 @default.
- W2060196721 cites W2110240929 @default.
- W2060196721 cites W2116638184 @default.
- W2060196721 cites W2120596330 @default.
- W2060196721 cites W2129399226 @default.
- W2060196721 cites W2135801240 @default.
- W2060196721 cites W2136597648 @default.
- W2060196721 cites W2159488906 @default.
- W2060196721 cites W2340064264 @default.
- W2060196721 cites W4232755968 @default.
- W2060196721 doi "https://doi.org/10.1017/s1461145709991106" @default.
- W2060196721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20003620" @default.
- W2060196721 hasPublicationYear "2010" @default.
- W2060196721 type Work @default.
- W2060196721 sameAs 2060196721 @default.
- W2060196721 citedByCount "21" @default.
- W2060196721 countsByYear W20601967212012 @default.
- W2060196721 countsByYear W20601967212013 @default.
- W2060196721 countsByYear W20601967212014 @default.
- W2060196721 countsByYear W20601967212015 @default.
- W2060196721 countsByYear W20601967212016 @default.
- W2060196721 countsByYear W20601967212017 @default.
- W2060196721 countsByYear W20601967212018 @default.
- W2060196721 countsByYear W20601967212022 @default.
- W2060196721 countsByYear W20601967212023 @default.
- W2060196721 crossrefType "journal-article" @default.
- W2060196721 hasAuthorship W2060196721A5018709602 @default.
- W2060196721 hasAuthorship W2060196721A5023323655 @default.
- W2060196721 hasAuthorship W2060196721A5067258427 @default.
- W2060196721 hasAuthorship W2060196721A5079620447 @default.
- W2060196721 hasBestOaLocation W20601967211 @default.
- W2060196721 hasConcept C108154423 @default.
- W2060196721 hasConcept C122871604 @default.
- W2060196721 hasConcept C148762608 @default.
- W2060196721 hasConcept C1491633281 @default.
- W2060196721 hasConcept C151730666 @default.
- W2060196721 hasConcept C15744967 @default.
- W2060196721 hasConcept C169760540 @default.
- W2060196721 hasConcept C2779144063 @default.
- W2060196721 hasConcept C2779343474 @default.
- W2060196721 hasConcept C2780451725 @default.
- W2060196721 hasConcept C2781161787 @default.
- W2060196721 hasConcept C48455012 @default.
- W2060196721 hasConcept C54355233 @default.
- W2060196721 hasConcept C85789140 @default.