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• W2060197675 abstract "The catalytic activities of recombinant cytochrome P450s expressed in E. coli have been impeded by the absence of endogenous P450 reductase. To solve this problem, we coexpressed P450 reductase with CYP3A4. Membranes from this strain contained 215 pmol P450/mg protein and a reductase activity of 1315 nmol cytochrome c reduced/min per mg. We detected 6β‐hydroxylation of testosterone and oxidation of nifedipine in vivo with turnover numbers of 15.2 and 17.3 min −1 , respectively. These values compare favourably with those obtained using an optimally reconstituted system. Our data demonstrate that a catalytically efficient human P450 system can be generated in E. coli ." @default.
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• W2060197675 date "1996-11-18" @default.
• W2060197675 modified "2023-09-26" @default.
• W2060197675 title "Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in<i>Escherichia coli</i>" @default.
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• W2060197675 doi "https://doi.org/10.1016/s0014-5793(96)01196-9" @default.
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