Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060202251> ?p ?o ?g. }
- W2060202251 endingPage "898" @default.
- W2060202251 startingPage "887" @default.
- W2060202251 abstract "The NMDA receptor NR1 subunit has four splice variants that differ in their C-terminal, cytoplasmic domain. We investigated the contribution of the C-terminal cassettes, C0, C1, C2, and C2', to trafficking of NR1 in heterologous cells and neurons. We identified an ER retention signal (RRR) in the C1 cassette of NR1, which is similar to the RXR motif in ATP-sensitive K(+) channels (Zerangue et al., 1999). We found that surface expression of NR1-3, which contains C1, is due to a site on the C2' cassette, which includes the terminal 4 amino acid PDZ-interacting domain. This site suppresses ER retention of the C1 cassette and leads to surface expression. These findings suggest a role for PDZ proteins in facilitating the transition of receptors from an intracellular pool to the surface of the neuron." @default.
- W2060202251 created "2016-06-24" @default.
- W2060202251 creator A5022304025 @default.
- W2060202251 creator A5028658442 @default.
- W2060202251 creator A5041982872 @default.
- W2060202251 creator A5071397864 @default.
- W2060202251 creator A5084536369 @default.
- W2060202251 date "2000-12-01" @default.
- W2060202251 modified "2023-10-18" @default.
- W2060202251 title "PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants" @default.
- W2060202251 cites W1482915690 @default.
- W2060202251 cites W1507029368 @default.
- W2060202251 cites W1513132249 @default.
- W2060202251 cites W1527543972 @default.
- W2060202251 cites W1561260712 @default.
- W2060202251 cites W1570789308 @default.
- W2060202251 cites W1648575050 @default.
- W2060202251 cites W1863375292 @default.
- W2060202251 cites W1876061808 @default.
- W2060202251 cites W1969155399 @default.
- W2060202251 cites W1976709744 @default.
- W2060202251 cites W1979586675 @default.
- W2060202251 cites W1986605182 @default.
- W2060202251 cites W1998225973 @default.
- W2060202251 cites W2001797086 @default.
- W2060202251 cites W2002518521 @default.
- W2060202251 cites W2004468088 @default.
- W2060202251 cites W2006851823 @default.
- W2060202251 cites W2015285707 @default.
- W2060202251 cites W2017273324 @default.
- W2060202251 cites W2018328247 @default.
- W2060202251 cites W2025700116 @default.
- W2060202251 cites W2030284957 @default.
- W2060202251 cites W2041024256 @default.
- W2060202251 cites W2042042218 @default.
- W2060202251 cites W2043088702 @default.
- W2060202251 cites W2045893780 @default.
- W2060202251 cites W2049517532 @default.
- W2060202251 cites W2050356515 @default.
- W2060202251 cites W2053695860 @default.
- W2060202251 cites W2053980736 @default.
- W2060202251 cites W2059334396 @default.
- W2060202251 cites W2073355679 @default.
- W2060202251 cites W2076880531 @default.
- W2060202251 cites W2091763641 @default.
- W2060202251 cites W2093573816 @default.
- W2060202251 cites W2102443549 @default.
- W2060202251 cites W2106766643 @default.
- W2060202251 cites W2108675544 @default.
- W2060202251 cites W2110304317 @default.
- W2060202251 cites W2111112233 @default.
- W2060202251 cites W2114871465 @default.
- W2060202251 cites W2114911095 @default.
- W2060202251 cites W2119542618 @default.
- W2060202251 cites W2121239869 @default.
- W2060202251 cites W2128971155 @default.
- W2060202251 cites W2132971431 @default.
- W2060202251 cites W2134044586 @default.
- W2060202251 cites W2134680445 @default.
- W2060202251 cites W2144874949 @default.
- W2060202251 cites W2150675831 @default.
- W2060202251 cites W2150796852 @default.
- W2060202251 cites W2152696633 @default.
- W2060202251 cites W2158271064 @default.
- W2060202251 cites W2159075930 @default.
- W2060202251 cites W2164674870 @default.
- W2060202251 cites W2167988140 @default.
- W2060202251 cites W2168239295 @default.
- W2060202251 cites W2408822320 @default.
- W2060202251 cites W86630917 @default.
- W2060202251 doi "https://doi.org/10.1016/s0896-6273(00)00161-6" @default.
- W2060202251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11163274" @default.
- W2060202251 hasPublicationYear "2000" @default.
- W2060202251 type Work @default.
- W2060202251 sameAs 2060202251 @default.
- W2060202251 citedByCount "334" @default.
- W2060202251 countsByYear W20602022512012 @default.
- W2060202251 countsByYear W20602022512013 @default.
- W2060202251 countsByYear W20602022512014 @default.
- W2060202251 countsByYear W20602022512015 @default.
- W2060202251 countsByYear W20602022512016 @default.
- W2060202251 countsByYear W20602022512017 @default.
- W2060202251 countsByYear W20602022512018 @default.
- W2060202251 countsByYear W20602022512019 @default.
- W2060202251 countsByYear W20602022512020 @default.
- W2060202251 countsByYear W20602022512021 @default.
- W2060202251 countsByYear W20602022512022 @default.
- W2060202251 countsByYear W20602022512023 @default.
- W2060202251 crossrefType "journal-article" @default.
- W2060202251 hasAuthorship W2060202251A5022304025 @default.
- W2060202251 hasAuthorship W2060202251A5028658442 @default.
- W2060202251 hasAuthorship W2060202251A5041982872 @default.
- W2060202251 hasAuthorship W2060202251A5071397864 @default.
- W2060202251 hasAuthorship W2060202251A5084536369 @default.
- W2060202251 hasBestOaLocation W20602022511 @default.
- W2060202251 hasConcept C104292427 @default.
- W2060202251 hasConcept C104317684 @default.
- W2060202251 hasConcept C12554922 @default.