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• W2060202313 abstract "ABSTRACT Autolysis plays an essential role in bacterial cell division and lysis with β-lactam antibiotics. Accordingly, the expression of autolysins is tightly regulated by several endogenous regulators, including ArlRS, a two component regulatory system that has been shown to negatively regulate autolysis in methicillin-sensitive Staphylococcus aureus (MSSA) strains. In this study, we found that inactivation of arlRS does not play a role in autolysis of methicillin-resistant S. aureus (MRSA) strains, such as community-acquired (CA)-MRSA strains USA300 and MW2 or the hospital-acquired (HA)-MRSA strain COL. This contrasts with MSSA strains, including Newman, SH1000, RN6390, and 8325-4, where autolysis is affected by ArlRS. We further demonstrated that the striking difference in the roles of arlRS between MSSA and MRSA strains is not due to the methicillin resistance determinant mecA . Among known autolysins and their regulators, we found that arlRS represses lytN , while no effect was seen on atl , lytM , and lytH expression in both CA- and HA-MRSA strains. Transcriptional-fusion assays showed that the agr transcripts, RNAII and RNAIII, were significantly more downregulated in the arlRS mutant of MW2 than the MSSA strain Newman. Importantly, provision of agr RNAIII in trans to the MW2 arlRS mutant via a multicopy plasmid induced autolysis in this MRSA strain. Also, the autolytic phenotype in the arlRS mutant of MSSA strain Newman could be rescued by a mutation in either atl or lytM . Together, these data showed that ArlRS impacts autolysis differently in MSSA and MRSA strains." @default.
• W2060202313 created "2016-06-24" @default.
• W2060202313 creator A5021692136 @default.
• W2060202313 creator A5082360434 @default.
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• W2060202313 date "2012-02-15" @default.
• W2060202313 modified "2023-10-01" @default.
• W2060202313 title "Role of ArlRS in Autolysis in Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Strains" @default.
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• W2060202313 doi "https://doi.org/10.1128/jb.06261-11" @default.
• W2060202313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3272946" @default.
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