FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060203844> ?p ?o ?g. }

• W2060203844 endingPage "151" @default.
• W2060203844 startingPage "145" @default.
• W2060203844 abstract "We investigated the anti-inflammatory and immunomodulatory effect of simvastatin on articular cartilage via the inhibition of matrix metalloproteinase-3 (MMP-3), a matrix-degrading enzyme, in a mechanically induced experimental osteoarthritis (OA) animal model.Twenty-seven albino Wistar rats were divided in three groups of equal number. Unphysiologic loading of articular cartilage was simulated by transecting anterior cruciate ligaments of the right knees of 18 rats consisting of groups 1 and 2. Nine animals in group 2 received orally administered simvastatin 20 mg/kg per day by gavage for 8 weeks. Animals in group 3 were sham operated. All animals were sacrificed at postoperative 8 weeks. Effects of simvastatin on disease progression was evaluated by documenting OA changes in cartilage specimens using Osteoarthritis Research Society International (OARSI) OA cartilage histopathology assessment system scores combined with the percentage of MMP-3 expression in chondrocytes.Simvastatin treatment significantly down-regulated the percentage of MMP-3 expression in chondrocytes as assessed by immunohistochemistry methods. Suppression of this matrix-degrading enzyme by simvastatin also reduced OARSI scores, suggesting the potential for statins against OA progression.Following knee trauma, OA initiates at the molecular level in a short period of time. Irreversible structural changes in cartilage that require demanding treatment strategies led us to focus on effective measures to prevent OA. Statins have immunomodulatory and anti-inflammatory properties independent from their serum-cholesterol-lowering effects. One of these widely used drugs, simvastatin, showed beneficial effects on OA progression and extent by reducing cartilage degradation in our experimental setting. If these results are confirmed by human trials, simvastatin might be considered by orthopedic surgeons as a disease-modifying drug during the early inflammatory phase of posttraumatic OA." @default.
• W2060203844 created "2016-06-24" @default.
• W2060203844 creator A5020511041 @default.
• W2060203844 creator A5042269781 @default.
• W2060203844 creator A5083773991 @default.
• W2060203844 date "2011-08-24" @default.
• W2060203844 modified "2023-10-01" @default.
• W2060203844 title "Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3" @default.
• W2060203844 cites W118851396 @default.
• W2060203844 cites W1975549541 @default.
• W2060203844 cites W1978511310 @default.
• W2060203844 cites W1992845429 @default.
• W2060203844 cites W1996970202 @default.
• W2060203844 cites W2031942183 @default.
• W2060203844 cites W2034919108 @default.
• W2060203844 cites W2044651570 @default.
• W2060203844 cites W2055361189 @default.
• W2060203844 cites W2075572679 @default.
• W2060203844 cites W2088132299 @default.
• W2060203844 cites W2090593219 @default.
• W2060203844 cites W2095426237 @default.
• W2060203844 cites W2099427592 @default.
• W2060203844 cites W2101397851 @default.
• W2060203844 cites W2111554916 @default.
• W2060203844 cites W2120221873 @default.
• W2060203844 cites W2125933583 @default.
• W2060203844 cites W2142925530 @default.
• W2060203844 cites W2153192975 @default.
• W2060203844 cites W2155440953 @default.
• W2060203844 cites W2157852649 @default.
• W2060203844 cites W2167301035 @default.
• W2060203844 doi "https://doi.org/10.1007/s10195-011-0154-y" @default.
• W2060203844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3163794" @default.
• W2060203844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21863259" @default.
• W2060203844 hasPublicationYear "2011" @default.
• W2060203844 type Work @default.
• W2060203844 sameAs 2060203844 @default.
• W2060203844 citedByCount "31" @default.
• W2060203844 countsByYear W20602038442012 @default.
• W2060203844 countsByYear W20602038442013 @default.
• W2060203844 countsByYear W20602038442014 @default.
• W2060203844 countsByYear W20602038442015 @default.
• W2060203844 countsByYear W20602038442016 @default.
• W2060203844 countsByYear W20602038442017 @default.
• W2060203844 countsByYear W20602038442018 @default.
• W2060203844 countsByYear W20602038442019 @default.
• W2060203844 countsByYear W20602038442020 @default.
• W2060203844 countsByYear W20602038442021 @default.
• W2060203844 countsByYear W20602038442022 @default.
• W2060203844 countsByYear W20602038442023 @default.
• W2060203844 crossrefType "journal-article" @default.
• W2060203844 hasAuthorship W2060203844A5020511041 @default.
• W2060203844 hasAuthorship W2060203844A5042269781 @default.
• W2060203844 hasAuthorship W2060203844A5083773991 @default.
• W2060203844 hasBestOaLocation W20602038441 @default.
• W2060203844 hasConcept C105702510 @default.
• W2060203844 hasConcept C109523444 @default.
• W2060203844 hasConcept C126322002 @default.
• W2060203844 hasConcept C142724271 @default.
• W2060203844 hasConcept C198451711 @default.
• W2060203844 hasConcept C204787440 @default.
• W2060203844 hasConcept C2776164576 @default.
• W2060203844 hasConcept C2776329913 @default.
• W2060203844 hasConcept C2780550940 @default.
• W2060203844 hasConcept C2781403057 @default.
• W2060203844 hasConcept C71924100 @default.
• W2060203844 hasConcept C98274493 @default.
• W2060203844 hasConceptScore W2060203844C105702510 @default.
• W2060203844 hasConceptScore W2060203844C109523444 @default.
• W2060203844 hasConceptScore W2060203844C126322002 @default.
• W2060203844 hasConceptScore W2060203844C142724271 @default.
• W2060203844 hasConceptScore W2060203844C198451711 @default.
• W2060203844 hasConceptScore W2060203844C204787440 @default.
• W2060203844 hasConceptScore W2060203844C2776164576 @default.
• W2060203844 hasConceptScore W2060203844C2776329913 @default.
• W2060203844 hasConceptScore W2060203844C2780550940 @default.
• W2060203844 hasConceptScore W2060203844C2781403057 @default.
• W2060203844 hasConceptScore W2060203844C71924100 @default.
• W2060203844 hasConceptScore W2060203844C98274493 @default.
• W2060203844 hasIssue "3" @default.
• W2060203844 hasLocation W20602038441 @default.
• W2060203844 hasLocation W20602038442 @default.
• W2060203844 hasLocation W20602038443 @default.
• W2060203844 hasLocation W20602038444 @default.
• W2060203844 hasOpenAccess W2060203844 @default.
• W2060203844 hasPrimaryLocation W20602038441 @default.
• W2060203844 hasRelatedWork W2033329636 @default.
• W2060203844 hasRelatedWork W2321334548 @default.
• W2060203844 hasRelatedWork W2351601386 @default.
• W2060203844 hasRelatedWork W2365956654 @default.
• W2060203844 hasRelatedWork W2789338801 @default.
• W2060203844 hasRelatedWork W2789533472 @default.
• W2060203844 hasRelatedWork W2943357046 @default.
• W2060203844 hasRelatedWork W2982601852 @default.
• W2060203844 hasRelatedWork W3032819791 @default.
• W2060203844 hasRelatedWork W3151134744 @default.
• W2060203844 hasVolume "12" @default.
• W2060203844 isParatext "false" @default.

• next