FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060208016> ?p ?o ?g. }

• W2060208016 endingPage "411" @default.
• W2060208016 startingPage "403" @default.
• W2060208016 abstract "Free tissue transfers and replantation of amputated limbs are better tolerated by young adolescents than mature adults. The authors hypothesized that this observation may be, in part, because of an attenuated ischemia-reperfusion (IR) injury in younger patients. Because neutrophils have been identified as a critical cell line responsible for IR injury, the authors investigated the effects of animal age on the degree of neutrophil activation in a rat model. Activation was evaluated by monitoring expression of integrin surface markers (mean fluorescence intensity [MFI] of CD11b) and oxidative burst potential (MFI of dihydrorhodamine [DHR] oxidation) by flow cytometry in neutrophils analyzed after 4 hours of ischemia and 1, 4, and 16 hours of reperfusion in a gracilis muscle flap model in mature adult and young adolescent rats. Neutrophil activation was also evaluated in control sham-operated animals, which underwent elevation of gracilis muscle flaps without exposure to an ischemic insult. Muscle edema, determined by wet-to-dry muscle weight ratio, and muscle viability, determined by nitro blue tetrazolium (NBT) staining, were completed for gracilis muscles exposed to ischemia after 24 hours of reperfusion for each of the groups. Integrin expression, assessed by MFI of CD11b, was increased significantly in ischemic muscles of mature adult rats at 4 hours of reperfusion (71.10+/-3.53 MFI vs. 54.88+/-12.73 MFI, p=0.025). Neutrophil oxidative potential, assessed by MFI of DHR oxidation, was increased significantly in ischemic muscles of mature adult rats compared with young adolescent rats at 1 hour of reperfusion (78.10+/-9.53 MFI vs. 51.78+/-16.91 MFI, p=0.035) and 4 hours of reperfusion (83.69+/-15.29 MFI vs. 46.55+/-8.09 MFI, p=0.005). Increased edema formation was observed in the ischemic muscles of mature adult rats when compared with young adolescent rats (1.25+/-0.04 vs. 1.12+/-0.05, p=0.031) after 24 hours of reperfusion. A trend toward decreased muscle viability was observed in the mature adult rats when compared with young adolescent rats (23.7+/-3.1% NBT staining vs. 32.3+/-13.7% NBT staining, p=0.189) after 24 hours of reperfusion. The authors present evidence of an attenuated IR injury in young adolescent animals when compared with mature adult rats. These findings emphasize the importance that studies involving IR injury should be performed with consideration of animal age." @default.
• W2060208016 created "2016-06-24" @default.
• W2060208016 creator A5001044926 @default.
• W2060208016 creator A5008416673 @default.
• W2060208016 creator A5009307150 @default.
• W2060208016 creator A5014117531 @default.
• W2060208016 creator A5048015583 @default.
• W2060208016 creator A5073172718 @default.
• W2060208016 creator A5079867434 @default.
• W2060208016 creator A5089216871 @default.
• W2060208016 date "2003-04-01" @default.
• W2060208016 modified "2023-09-27" @default.
• W2060208016 title "Age-Related Differences of Neutrophil Activation in a Skeletal Muscle Ischemia–Reperfusion Model" @default.
• W2060208016 cites W1423878457 @default.
• W2060208016 cites W1537490335 @default.
• W2060208016 cites W1978180398 @default.
• W2060208016 cites W1983430625 @default.
• W2060208016 cites W1984989435 @default.
• W2060208016 cites W1991219464 @default.
• W2060208016 cites W2003877077 @default.
• W2060208016 cites W2004056423 @default.
• W2060208016 cites W2018206247 @default.
• W2060208016 cites W2026192524 @default.
• W2060208016 cites W2029433148 @default.
• W2060208016 cites W2029457093 @default.
• W2060208016 cites W2032413380 @default.
• W2060208016 cites W2039348809 @default.
• W2060208016 cites W2043354933 @default.
• W2060208016 cites W2045307242 @default.
• W2060208016 cites W2059229138 @default.
• W2060208016 cites W2063518265 @default.
• W2060208016 cites W2067281820 @default.
• W2060208016 cites W2080664825 @default.
• W2060208016 cites W2088315418 @default.
• W2060208016 cites W2106176667 @default.
• W2060208016 cites W2107748719 @default.
• W2060208016 cites W2130312879 @default.
• W2060208016 cites W2150802228 @default.
• W2060208016 cites W2151280704 @default.
• W2060208016 cites W2153450942 @default.
• W2060208016 cites W2160236069 @default.
• W2060208016 cites W2171423597 @default.
• W2060208016 cites W2277205276 @default.
• W2060208016 cites W2341557366 @default.
• W2060208016 cites W2344640730 @default.
• W2060208016 cites W2409886837 @default.
• W2060208016 cites W2414721476 @default.
• W2060208016 cites W4230693812 @default.
• W2060208016 cites W4233728890 @default.
• W2060208016 doi "https://doi.org/10.1097/01.sap.0000041663.28703.54" @default.
• W2060208016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12671384" @default.
• W2060208016 hasPublicationYear "2003" @default.
• W2060208016 type Work @default.
• W2060208016 sameAs 2060208016 @default.
• W2060208016 citedByCount "6" @default.
• W2060208016 countsByYear W20602080162013 @default.
• W2060208016 countsByYear W20602080162014 @default.
• W2060208016 countsByYear W20602080162018 @default.
• W2060208016 crossrefType "journal-article" @default.
• W2060208016 hasAuthorship W2060208016A5001044926 @default.
• W2060208016 hasAuthorship W2060208016A5008416673 @default.
• W2060208016 hasAuthorship W2060208016A5009307150 @default.
• W2060208016 hasAuthorship W2060208016A5014117531 @default.
• W2060208016 hasAuthorship W2060208016A5048015583 @default.
• W2060208016 hasAuthorship W2060208016A5073172718 @default.
• W2060208016 hasAuthorship W2060208016A5079867434 @default.
• W2060208016 hasAuthorship W2060208016A5089216871 @default.
• W2060208016 hasConcept C126322002 @default.
• W2060208016 hasConcept C134018914 @default.
• W2060208016 hasConcept C16685009 @default.
• W2060208016 hasConcept C171779818 @default.
• W2060208016 hasConcept C203014093 @default.
• W2060208016 hasConcept C2779959927 @default.
• W2060208016 hasConcept C2780114680 @default.
• W2060208016 hasConcept C2780371428 @default.
• W2060208016 hasConcept C2780886150 @default.
• W2060208016 hasConcept C541997718 @default.
• W2060208016 hasConcept C553184892 @default.
• W2060208016 hasConcept C55493867 @default.
• W2060208016 hasConcept C57600042 @default.
• W2060208016 hasConcept C71924100 @default.
• W2060208016 hasConcept C86803240 @default.
• W2060208016 hasConceptScore W2060208016C126322002 @default.
• W2060208016 hasConceptScore W2060208016C134018914 @default.
• W2060208016 hasConceptScore W2060208016C16685009 @default.
• W2060208016 hasConceptScore W2060208016C171779818 @default.
• W2060208016 hasConceptScore W2060208016C203014093 @default.
• W2060208016 hasConceptScore W2060208016C2779959927 @default.
• W2060208016 hasConceptScore W2060208016C2780114680 @default.
• W2060208016 hasConceptScore W2060208016C2780371428 @default.
• W2060208016 hasConceptScore W2060208016C2780886150 @default.
• W2060208016 hasConceptScore W2060208016C541997718 @default.
• W2060208016 hasConceptScore W2060208016C553184892 @default.
• W2060208016 hasConceptScore W2060208016C55493867 @default.
• W2060208016 hasConceptScore W2060208016C57600042 @default.
• W2060208016 hasConceptScore W2060208016C71924100 @default.
• W2060208016 hasConceptScore W2060208016C86803240 @default.
• W2060208016 hasIssue "4" @default.

• next