FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060212567> ?p ?o ?g. }

• W2060212567 endingPage "196" @default.
• W2060212567 startingPage "191" @default.
• W2060212567 abstract "Circadian timing largely modifies efficacy of many medicinal drugs. This viewpoint has been applied in the clinical medicine, known as chronotherapy. We think this viewpoint should also be introduced into toxicology as “chronotoxicology”, however, information about the diurnal variation in toxicant sensitivity is still very scarce. We present here a clear and reproducible diurnal variation of cadmium (Cd)-induced mortality in mice. Male ICR mice kept under standard condition (12 hr light/dark cycle, lights on at 08:00) were injected with CdCl2 (7.2 mg/kg, one shot) intraperitoneally at different time points in the day (zeitgeber time (ZT) 0, 4, 8, 12, 16 or 20). Survival number was determined at 14 days after injection. Interestingly, mice were sensitive to Cd acute toxicity at ZT8, while tolerant at mid-dark to early-light phase (ZT16, ZT20 and ZT0). Hepatic GSH level showed small daily fluctuation, lowest at ZT8 and highest at ZT20, and this fluctuation was similar to the diurnal variation of Cd sensitivity. In contrast, hepatic metallothionein (MT) level was not significant in these time points, although their level also showed small daily fluctuation. Our results indicated that Cd-induced mortality had clear diurnal variation, and suggested that the hepatic GSH level was one of the important factors for determination of this Cd-induced diurnal mortality." @default.
• W2060212567 created "2016-06-24" @default.
• W2060212567 creator A5030623241 @default.
• W2060212567 creator A5032766776 @default.
• W2060212567 creator A5043734300 @default.
• W2060212567 creator A5054809004 @default.
• W2060212567 creator A5063405768 @default.
• W2060212567 creator A5068670495 @default.
• W2060212567 date "2012-01-01" @default.
• W2060212567 modified "2023-10-12" @default.
• W2060212567 title "Diurnal variation of cadmium-induced mortality in mice" @default.
• W2060212567 cites W1607214797 @default.
• W2060212567 cites W1664552158 @default.
• W2060212567 cites W1836945052 @default.
• W2060212567 cites W1987890337 @default.
• W2060212567 cites W1993304022 @default.
• W2060212567 cites W1996506892 @default.
• W2060212567 cites W1998398302 @default.
• W2060212567 cites W1998438854 @default.
• W2060212567 cites W2009523371 @default.
• W2060212567 cites W2017808300 @default.
• W2060212567 cites W2020485769 @default.
• W2060212567 cites W2030128793 @default.
• W2060212567 cites W2030996473 @default.
• W2060212567 cites W2032498368 @default.
• W2060212567 cites W2032949485 @default.
• W2060212567 cites W2034900642 @default.
• W2060212567 cites W2045904650 @default.
• W2060212567 cites W2050941212 @default.
• W2060212567 cites W2069605932 @default.
• W2060212567 cites W2082252534 @default.
• W2060212567 cites W2086215413 @default.
• W2060212567 cites W2098407672 @default.
• W2060212567 cites W2120740251 @default.
• W2060212567 cites W2136645014 @default.
• W2060212567 cites W2140425355 @default.
• W2060212567 cites W2142478420 @default.
• W2060212567 cites W2146242475 @default.
• W2060212567 cites W2146960723 @default.
• W2060212567 cites W2146987478 @default.
• W2060212567 cites W2152841401 @default.
• W2060212567 cites W2157611470 @default.
• W2060212567 cites W4376596268 @default.
• W2060212567 cites W3141743956 @default.
• W2060212567 doi "https://doi.org/10.2131/jts.37.191" @default.
• W2060212567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22293423" @default.
• W2060212567 hasPublicationYear "2012" @default.
• W2060212567 type Work @default.
• W2060212567 sameAs 2060212567 @default.
• W2060212567 citedByCount "20" @default.
• W2060212567 countsByYear W20602125672012 @default.
• W2060212567 countsByYear W20602125672013 @default.
• W2060212567 countsByYear W20602125672014 @default.
• W2060212567 countsByYear W20602125672015 @default.
• W2060212567 countsByYear W20602125672016 @default.
• W2060212567 countsByYear W20602125672017 @default.
• W2060212567 countsByYear W20602125672018 @default.
• W2060212567 countsByYear W20602125672019 @default.
• W2060212567 countsByYear W20602125672021 @default.
• W2060212567 countsByYear W20602125672022 @default.
• W2060212567 crossrefType "journal-article" @default.
• W2060212567 hasAuthorship W2060212567A5030623241 @default.
• W2060212567 hasAuthorship W2060212567A5032766776 @default.
• W2060212567 hasAuthorship W2060212567A5043734300 @default.
• W2060212567 hasAuthorship W2060212567A5054809004 @default.
• W2060212567 hasAuthorship W2060212567A5063405768 @default.
• W2060212567 hasAuthorship W2060212567A5068670495 @default.
• W2060212567 hasBestOaLocation W20602125671 @default.
• W2060212567 hasConcept C121446783 @default.
• W2060212567 hasConcept C126322002 @default.
• W2060212567 hasConcept C127313418 @default.
• W2060212567 hasConcept C134018914 @default.
• W2060212567 hasConcept C140793950 @default.
• W2060212567 hasConcept C167678106 @default.
• W2060212567 hasConcept C178790620 @default.
• W2060212567 hasConcept C181199279 @default.
• W2060212567 hasConcept C185592680 @default.
• W2060212567 hasConcept C21786239 @default.
• W2060212567 hasConcept C2780473477 @default.
• W2060212567 hasConcept C29730261 @default.
• W2060212567 hasConcept C33070731 @default.
• W2060212567 hasConcept C38606739 @default.
• W2060212567 hasConcept C42407357 @default.
• W2060212567 hasConcept C538909803 @default.
• W2060212567 hasConcept C544657597 @default.
• W2060212567 hasConcept C55493867 @default.
• W2060212567 hasConcept C71924100 @default.
• W2060212567 hasConcept C86803240 @default.
• W2060212567 hasConcept C91586092 @default.
• W2060212567 hasConcept C98274493 @default.
• W2060212567 hasConceptScore W2060212567C121446783 @default.
• W2060212567 hasConceptScore W2060212567C126322002 @default.
• W2060212567 hasConceptScore W2060212567C127313418 @default.
• W2060212567 hasConceptScore W2060212567C134018914 @default.
• W2060212567 hasConceptScore W2060212567C140793950 @default.
• W2060212567 hasConceptScore W2060212567C167678106 @default.
• W2060212567 hasConceptScore W2060212567C178790620 @default.
• W2060212567 hasConceptScore W2060212567C181199279 @default.

• next