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- W2060216508 abstract "INTRODUCTION: Juvenile Onset Recurrent Respiratory Papillomatosis (JORRP) is a rare condition characterized by recurrent growth of squamous papillomas in the upper and lower airways of children younger than twelve years old. It is caused by the cytopathogenic effect of human papilloma virus (HPV) 6, 11, 16/18 and 31/35/51, which is transmitted from active vaginal lesions of the infected mother at the time of birth. JORRP has a prevalence of 1.7–2.6/100,000 children. It typically presents with hoarseness which can progress to stridor. Multiple surgical interventions are often required to achieve local control of the disease and avoid airway obstruction. Involvement of the upper airway is common, especially the larynx. However, papillomas can also spread to the distal trachea and lung parenchyma in 5% of the cases. Several cases of malignant transformation have been reported in patients with JORRP in the setting of concomitant risk factors such as radiation or smoking. However, only few cases have been published describing malignant transformation of papillomas of the lung in the absence of these risks factors. We present a case of a 19 year-old woman with history of JORRP, who developed squamous cell carcinoma of the lung after being in clinical remission since the age of 5." @default.
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- W2060216508 date "2009-10-01" @default.
- W2060216508 modified "2023-10-14" @default.
- W2060216508 title "A CASE OF A 19 YEAR OLD WOMAN WITH SQUAMOUS CELL CARCINOMA OF THE LUNG" @default.
- W2060216508 cites W2016006753 @default.
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- W2060216508 doi "https://doi.org/10.1378/chest.136.4_meetingabstracts.31s-d" @default.
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