FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060219173> ?p ?o ?g. }

• W2060219173 endingPage "614" @default.
• W2060219173 startingPage "608" @default.
• W2060219173 abstract "Hydroxylations of dehydroepiandrosterone (DHEA) at the 7 alpha- and 7 beta- positions have been reported in numerous murine tissues and organs, including liver, and the responsible cytochrome P450 (P450) species await identification. Using thin layer chromatography and gas chromatography-mass spectrometry, we report identification of 7 alpha-hydroxy-DHEA and 7 beta-hydroxy-DHEA metabolites produced in mouse liver microsome digests and kinetic studies of their production with apparent KM values of 3.19 +/- 0.292 microM and 2.82 +/- 0.241 microM for 7 alpha- and 7 beta-hydroxylation, respectively. Investigation of P450 inhibitor and of steroid hormone effects on both 7 alpha- and 7 beta-hydroxylation of DHEA showed that, 1) different P450s were involved in 7 alpha- and 7 beta-hydroxylation of DHEA because metyrapone inhibited solely 7 alpha-hydroxylation, 2) P450 2D6, 2B1, and 2B11 were not responsible for 7 alpha- and 7 beta-hydroxylation of DHEA because respective specific inhibitors quinidine and chloramphenicol triggered no inhibition, 3) aside from P450 7b, P450 1A1, and 1A2 may be responsible for a fraction of DHEA 7 alpha- and 7 beta-hydroxylation because alpha-naphthoflavone and furafylline, which inhibit specifically P450 1A1 and 1A2, decreased the 7 alpha- and 7 beta-hydroxylation partly, 4) comparison of these findings with those obtained with brain microsomes suggested that tissue-specific P450 species are responsible for the 7 alpha- and 7 beta-hydroxylation of DHEA, 5) 7 alpha-hydroxylation of DHEA may be shared with other 3 beta-hydroxysteroids, such as 3 beta-hydroxy-5 alpha-androstan-17-one, 5-androstene-3 beta,17 beta-diol and pregnenolone, which acted in a noncompetitive manner. Taken together, these findings will be of use for identification of the P450 species responsible for 7 alpha- and 7 beta-hydroxylation of DHEA and for studies of their activities in liver." @default.
• W2060219173 created "2016-06-24" @default.
• W2060219173 creator A5029283562 @default.
• W2060219173 creator A5037554997 @default.
• W2060219173 creator A5063610325 @default.
• W2060219173 creator A5073974324 @default.
• W2060219173 date "1998-11-01" @default.
• W2060219173 modified "2023-09-27" @default.
• W2060219173 title "Inhibition studies of dehydroepiandrosterone 7α- and 7β-hydroxylation in mouse liver microsomes" @default.
• W2060219173 cites W1489599147 @default.
• W2060219173 cites W1775749144 @default.
• W2060219173 cites W1964717152 @default.
• W2060219173 cites W1978172456 @default.
• W2060219173 cites W1978630815 @default.
• W2060219173 cites W1983288060 @default.
• W2060219173 cites W1987756608 @default.
• W2060219173 cites W2000053492 @default.
• W2060219173 cites W2001360811 @default.
• W2060219173 cites W2001456437 @default.
• W2060219173 cites W2006869450 @default.
• W2060219173 cites W2016782169 @default.
• W2060219173 cites W2017242560 @default.
• W2060219173 cites W2027233092 @default.
• W2060219173 cites W2037812043 @default.
• W2060219173 cites W2044719874 @default.
• W2060219173 cites W2049770869 @default.
• W2060219173 cites W2051638979 @default.
• W2060219173 cites W2053481602 @default.
• W2060219173 cites W2061895817 @default.
• W2060219173 cites W2063518072 @default.
• W2060219173 cites W2065717171 @default.
• W2060219173 cites W2067405103 @default.
• W2060219173 cites W2076136095 @default.
• W2060219173 cites W2082746241 @default.
• W2060219173 cites W2083003126 @default.
• W2060219173 cites W2088079257 @default.
• W2060219173 cites W2112351867 @default.
• W2060219173 cites W2140093413 @default.
• W2060219173 cites W2156112350 @default.
• W2060219173 cites W2164646340 @default.
• W2060219173 cites W30137230 @default.
• W2060219173 doi "https://doi.org/10.1016/s0039-128x(98)00071-3" @default.
• W2060219173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9830688" @default.
• W2060219173 hasPublicationYear "1998" @default.
• W2060219173 type Work @default.
• W2060219173 sameAs 2060219173 @default.
• W2060219173 citedByCount "29" @default.
• W2060219173 countsByYear W20602191732012 @default.
• W2060219173 countsByYear W20602191732015 @default.
• W2060219173 countsByYear W20602191732016 @default.
• W2060219173 countsByYear W20602191732017 @default.
• W2060219173 countsByYear W20602191732020 @default.
• W2060219173 crossrefType "journal-article" @default.
• W2060219173 hasAuthorship W2060219173A5029283562 @default.
• W2060219173 hasAuthorship W2060219173A5037554997 @default.
• W2060219173 hasAuthorship W2060219173A5063610325 @default.
• W2060219173 hasAuthorship W2060219173A5073974324 @default.
• W2060219173 hasConcept C126322002 @default.
• W2060219173 hasConcept C134018914 @default.
• W2060219173 hasConcept C159110408 @default.
• W2060219173 hasConcept C181199279 @default.
• W2060219173 hasConcept C185592680 @default.
• W2060219173 hasConcept C199360897 @default.
• W2060219173 hasConcept C2775944032 @default.
• W2060219173 hasConcept C2776174256 @default.
• W2060219173 hasConcept C2776992908 @default.
• W2060219173 hasConcept C2777911890 @default.
• W2060219173 hasConcept C2781109383 @default.
• W2060219173 hasConcept C41008148 @default.
• W2060219173 hasConcept C49453240 @default.
• W2060219173 hasConcept C526171541 @default.
• W2060219173 hasConcept C55493867 @default.
• W2060219173 hasConcept C62231903 @default.
• W2060219173 hasConcept C64943373 @default.
• W2060219173 hasConcept C71315377 @default.
• W2060219173 hasConcept C71924100 @default.
• W2060219173 hasConcept C86803240 @default.
• W2060219173 hasConcept C87644729 @default.
• W2060219173 hasConceptScore W2060219173C126322002 @default.
• W2060219173 hasConceptScore W2060219173C134018914 @default.
• W2060219173 hasConceptScore W2060219173C159110408 @default.
• W2060219173 hasConceptScore W2060219173C181199279 @default.
• W2060219173 hasConceptScore W2060219173C185592680 @default.
• W2060219173 hasConceptScore W2060219173C199360897 @default.
• W2060219173 hasConceptScore W2060219173C2775944032 @default.
• W2060219173 hasConceptScore W2060219173C2776174256 @default.
• W2060219173 hasConceptScore W2060219173C2776992908 @default.
• W2060219173 hasConceptScore W2060219173C2777911890 @default.
• W2060219173 hasConceptScore W2060219173C2781109383 @default.
• W2060219173 hasConceptScore W2060219173C41008148 @default.
• W2060219173 hasConceptScore W2060219173C49453240 @default.
• W2060219173 hasConceptScore W2060219173C526171541 @default.
• W2060219173 hasConceptScore W2060219173C55493867 @default.
• W2060219173 hasConceptScore W2060219173C62231903 @default.
• W2060219173 hasConceptScore W2060219173C64943373 @default.
• W2060219173 hasConceptScore W2060219173C71315377 @default.
• W2060219173 hasConceptScore W2060219173C71924100 @default.
• W2060219173 hasConceptScore W2060219173C86803240 @default.

• next