FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060219370> ?p ?o ?g. }

• W2060219370 endingPage "779" @default.
• W2060219370 startingPage "773" @default.
• W2060219370 abstract "Our previous work has demonstrated that alterations in placental function are associated with changes in fetal development in pregnancies complicated by asthma. The pathophysiology of asthma in adults and children and intrauterine growth restriction during pregnancy are associated with oxidative stress. Based on this information, we examined whether placental anti-oxidant pathways and markers of biological oxidation were altered in pregnancies complicated by asthma. Anti-oxidant enzyme activities of superoxide dismutase, glutathione peroxidase and thioredoxin reductase, thioredoxin concentrations, lipid and protein oxidation levels were measured in placentae of pregnancies complicated by asthma and compared to uncomplicated, non-asthmatic pregnancies. Placental tissue homogenates of pregnancies complicated by asthma demonstrated significantly increased levels of lipid peroxidation (25.7+/-1.8 micromol/mg protein versus 12.1+/-1.6 micromol/mg protein, P=0.008) and protein carbonyl concentrations (414.6+/-51.4 units/mg protein versus 222.3+/-32.6 units/mg protein, P=0.0032) when compared to non-asthmatic controls. The activities of the anti-oxidant proteins superoxide dismutase (2.17+/-0.09 units/mg protein versus 1.67+/-0.09 units/mg protein, P=0.014) and thioredoxin reductase (54.0+/-6.9 units/mg protein versus 28.7+/-6.0 units/mg protein, P=0.009) were significantly increased in the presence of maternal asthma. Placental thioredoxin levels (102.9+/-5.3 ng/mg protein versus 92.9+/-8.6 ng/mg protein, P=0.37) and glutathione peroxidase activity (27.3+/-2.2 mmol/min/mg protein versus 28.3+/-2.2 mmol/min/mg, P=0.83) were not significantly different in pregnancies complicated by asthma and non-asthmatic pregnancies. There was no effect of fetal sex, asthma severity or treatment for asthma on these pathways. Maternal asthma during pregnancy is associated with increased placental enzymatic anti-oxidant capacity and also increased protein oxidation suggesting there is a compensatory increase in anti-oxidant activity in response to increased oxidative stress." @default.
• W2060219370 created "2016-06-24" @default.
• W2060219370 creator A5059908511 @default.
• W2060219370 creator A5062439270 @default.
• W2060219370 creator A5090518842 @default.
• W2060219370 date "2005-11-01" @default.
• W2060219370 modified "2023-09-26" @default.
• W2060219370 title "Increased anti-oxidant enzyme activity and biological oxidation in placentae of pregnancies complicated by maternal asthma" @default.
• W2060219370 cites W1536097609 @default.
• W2060219370 cites W1857502105 @default.
• W2060219370 cites W1973905104 @default.
• W2060219370 cites W1980734408 @default.
• W2060219370 cites W1984119010 @default.
• W2060219370 cites W1990730995 @default.
• W2060219370 cites W1996185139 @default.
• W2060219370 cites W2006228166 @default.
• W2060219370 cites W2009800909 @default.
• W2060219370 cites W2011322115 @default.
• W2060219370 cites W2019938547 @default.
• W2060219370 cites W2036287465 @default.
• W2060219370 cites W2038042834 @default.
• W2060219370 cites W2049268036 @default.
• W2060219370 cites W2049279081 @default.
• W2060219370 cites W2053616622 @default.
• W2060219370 cites W2059578393 @default.
• W2060219370 cites W2064623678 @default.
• W2060219370 cites W2065020384 @default.
• W2060219370 cites W2067410074 @default.
• W2060219370 cites W2077941158 @default.
• W2060219370 cites W2078592237 @default.
• W2060219370 cites W2081546032 @default.
• W2060219370 cites W2087025400 @default.
• W2060219370 cites W2090808570 @default.
• W2060219370 cites W2091829612 @default.
• W2060219370 cites W2094877101 @default.
• W2060219370 cites W2103581278 @default.
• W2060219370 cites W2107340075 @default.
• W2060219370 cites W2125006192 @default.
• W2060219370 cites W2140914037 @default.
• W2060219370 cites W2150201883 @default.
• W2060219370 cites W4242814566 @default.
• W2060219370 doi "https://doi.org/10.1016/j.placenta.2004.10.018" @default.
• W2060219370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16226128" @default.
• W2060219370 hasPublicationYear "2005" @default.
• W2060219370 type Work @default.
• W2060219370 sameAs 2060219370 @default.
• W2060219370 citedByCount "29" @default.
• W2060219370 countsByYear W20602193702012 @default.
• W2060219370 countsByYear W20602193702013 @default.
• W2060219370 countsByYear W20602193702014 @default.
• W2060219370 countsByYear W20602193702015 @default.
• W2060219370 countsByYear W20602193702016 @default.
• W2060219370 countsByYear W20602193702017 @default.
• W2060219370 countsByYear W20602193702018 @default.
• W2060219370 countsByYear W20602193702020 @default.
• W2060219370 countsByYear W20602193702022 @default.
• W2060219370 countsByYear W20602193702023 @default.
• W2060219370 crossrefType "journal-article" @default.
• W2060219370 hasAuthorship W2060219370A5059908511 @default.
• W2060219370 hasAuthorship W2060219370A5062439270 @default.
• W2060219370 hasAuthorship W2060219370A5090518842 @default.
• W2060219370 hasConcept C126322002 @default.
• W2060219370 hasConcept C134018914 @default.
• W2060219370 hasConcept C165069038 @default.
• W2060219370 hasConcept C16685009 @default.
• W2060219370 hasConcept C172680121 @default.
• W2060219370 hasConcept C181199279 @default.
• W2060219370 hasConcept C185592680 @default.
• W2060219370 hasConcept C2775838275 @default.
• W2060219370 hasConcept C2776042228 @default.
• W2060219370 hasConcept C2776151105 @default.
• W2060219370 hasConcept C2776953305 @default.
• W2060219370 hasConcept C2777737464 @default.
• W2060219370 hasConcept C2778760513 @default.
• W2060219370 hasConcept C2779234561 @default.
• W2060219370 hasConcept C2780829032 @default.
• W2060219370 hasConcept C3623737 @default.
• W2060219370 hasConcept C538909803 @default.
• W2060219370 hasConcept C54355233 @default.
• W2060219370 hasConcept C55493867 @default.
• W2060219370 hasConcept C71924100 @default.
• W2060219370 hasConcept C86803240 @default.
• W2060219370 hasConceptScore W2060219370C126322002 @default.
• W2060219370 hasConceptScore W2060219370C134018914 @default.
• W2060219370 hasConceptScore W2060219370C165069038 @default.
• W2060219370 hasConceptScore W2060219370C16685009 @default.
• W2060219370 hasConceptScore W2060219370C172680121 @default.
• W2060219370 hasConceptScore W2060219370C181199279 @default.
• W2060219370 hasConceptScore W2060219370C185592680 @default.
• W2060219370 hasConceptScore W2060219370C2775838275 @default.
• W2060219370 hasConceptScore W2060219370C2776042228 @default.
• W2060219370 hasConceptScore W2060219370C2776151105 @default.
• W2060219370 hasConceptScore W2060219370C2776953305 @default.
• W2060219370 hasConceptScore W2060219370C2777737464 @default.
• W2060219370 hasConceptScore W2060219370C2778760513 @default.
• W2060219370 hasConceptScore W2060219370C2779234561 @default.
• W2060219370 hasConceptScore W2060219370C2780829032 @default.
• W2060219370 hasConceptScore W2060219370C3623737 @default.

• next