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• W2060219375 abstract "Among the recently cloned serotonin (5-hydroxytryptamine, 5-HT) receptors, the 5-HT6subtype is of special interest for at least two reasons: 1) it is abundant in limbic areas which participate in the control of mood and emotion; and 2) some antidepressants and antipsychotics are potent 5-HT6receptor antagonists. Studies using polyclonal anti-5-HT6receptor antibodies and an antisense oligonucleotide were performed in order to investigate further the function(s) of 5-HT6receptors in the rat brain. Immunocytochemistry at the light and electron microscope levels showed that 5-HT6receptors are mainly confined to the dendritic compartment, suggesting that they could mediate 5-HT actions on neuronal firing. In some limbic areas, 5-HT6receptor-like immunoreactivity is also associated with neuronal cilia with yet unknown functions. Continuous i.c.v. infusion with an antisense oligonucleotide for 3–4 days resulted in decreased 5-HT6receptor-like immunostaining of the nucleus accumbens and anxiogenic behaviours in the social interaction and elevated plus maze tests. Selective 5-HT6 receptor ligands are eagerly expected to investigate further the potential implication of these receptors in limbic-dependent behaviours." @default.
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• W2060219375 date "1999-08-01" @default.
• W2060219375 modified "2023-10-15" @default.
• W2060219375 title "Antibodies and Antisense Oligonucleotide for Probing the Distribution and Putative Functions of Central 5-HT6 Receptors" @default.
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• W2060219375 doi "https://doi.org/10.1016/s0893-133x(99)00044-5" @default.
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