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• W2060237555 endingPage "5054" @default.
• W2060237555 startingPage "5039" @default.
• W2060237555 abstract "Cotia virus (COTV) SPAn232 was isolated in 1961 from sentinel mice at Cotia field station, São Paulo, Brazil. Attempts to classify COTV within a recognized genus of the Poxviridae have generated contradictory findings. Studies by different researchers suggested some similarity to myxoma virus and swinepox virus, whereas another investigation characterized COTV SPAn232 as a vaccinia virus strain. Because of the lack of consensus, we have conducted an independent biological and molecular characterization of COTV. Virus growth curves reached maximum yields at approximately 24 to 48 h and were accompanied by virus DNA replication and a characteristic early/late pattern of viral protein synthesis. Interestingly, COTV did not induce detectable cytopathic effects in BSC-40 cells until 4 days postinfection and generated viral plaques only after 8 days. We determined the complete genomic sequence of COTV by using a combination of the next-generation DNA sequencing technologies 454 and Illumina. A unique contiguous sequence of 185,139 bp containing 185 genes, including the 90 genes conserved in all chordopoxviruses, was obtained. COTV has an interesting panel of open reading frames (ORFs) related to the evasion of host defense, including two novel genes encoding C-C chemokine-like proteins, each present in duplicate copies. Phylogenetic analysis revealed the highest amino acid identity scores with Cervidpoxvirus, Capripoxvirus, Suipoxvirus, Leporipoxvirus, and Yatapoxvirus. However, COTV grouped as an independent branch within this clade, which clearly excluded its classification as an Orthopoxvirus. Therefore, our data suggest that COTV could represent a new poxvirus genus." @default.
• W2060237555 created "2016-06-24" @default.
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• W2060237555 date "2012-05-01" @default.
• W2060237555 modified "2023-09-27" @default.
• W2060237555 title "Biological Characterization and Next-Generation Genome Sequencing of the Unclassified Cotia Virus SPAn232 (Poxviridae)" @default.
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• W2060237555 doi "https://doi.org/10.1128/jvi.07162-11" @default.
• W2060237555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3347363" @default.
• W2060237555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22345477" @default.
• W2060237555 hasPublicationYear "2012" @default.
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