Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060264695> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2060264695 endingPage "843" @default.
- W2060264695 startingPage "839" @default.
- W2060264695 abstract "Aortic rings, 4 mm in length, were obtained from rats and placed on isometric force transducers in oxygenated Krebs buffer. Following a period of stabilization, the cumulative dose response relationship to norepinephrine was assessed. The vessels were washed and allowed to return to baseline in Krebs buffer containing xanthine (0.5 mM). Xanthine oxidase (0.1 U/ml) was then added to the bath and vessels incubated for 30 min. The vessels were resuspended in Krebs buffer and cumulative dose-response curves to norepinephrine reevaluated. The results indicate that generation of reactive oxygen metabolites by xanthine/xanthine oxidase decreases the pD2 from 7.80 ± 0.04 to 7.40 ± 0.09 with the endothelium intact. Removal of the endothelium did not attenuate the contractile dysfunction, indicating that endothelial-derived metabolites were not mediating the loss of vasoconstrictor effectiveness. Maximal tension development did not differ between normal and oxidized vessel rings. Introduction of oxypurinol (0.2 mg/ml) to the bath prevented the loss of constrictor responsiveness, thereby confirming that all of the oxidants were derived from the xanthine/xanthine oxidase reaction. Superoxide dismutase (200 U/ml) partially prevented the loss of norepinephrine responsiveness produced by xanthine oxidase-derived radicals. The pD2 in the SOD + xanthine/xanthine oxidase-treated vessels rings (7.19 ± 0.11) was significantly lower tan control vessel rings (7.49 ± 0.04) and significantly higher than xanthine/xanthine oxidase-treated vessels (6.89 ± 0.06). Catalase (1000 U/ml) also partially attenuated the loss of vascular norepinephrine responsiveness. The pD2 for the catalase + xanthine/xanthine oxidase-treated vessels (7.15 ± 0.02) was significantly lower than control vessels (7.39 ± 0.07)and significantly higher than the xanthine/xanthine oxidase-treated vessels (6.82 ± 0.11). The pD2 of vessels treated with a combination of SOD and catalase (7.40 ± 0.10) did not differ from control vessels (7.49 ± 0.12). The results of this study indicate that reactive species produced by the interaction of xanthine with xanthine oxidase depress norepinephrine-induced vasoconstriction. The loss of vasoconstrictor responsiveness appears to involve both superoxide and hydrogen peroxide." @default.
- W2060264695 created "2016-06-24" @default.
- W2060264695 creator A5020670999 @default.
- W2060264695 creator A5054700319 @default.
- W2060264695 creator A5073021091 @default.
- W2060264695 date "1994-06-01" @default.
- W2060264695 modified "2023-10-14" @default.
- W2060264695 title "Effects of reactive oxygen metabolites on norepinephrine-induced vasoconstriction" @default.
- W2060264695 cites W1522676079 @default.
- W2060264695 cites W1772472840 @default.
- W2060264695 cites W2050227443 @default.
- W2060264695 cites W2058137293 @default.
- W2060264695 cites W206156202 @default.
- W2060264695 cites W2073943368 @default.
- W2060264695 cites W2086610284 @default.
- W2060264695 cites W2135749989 @default.
- W2060264695 cites W2285708410 @default.
- W2060264695 cites W2412108779 @default.
- W2060264695 doi "https://doi.org/10.1016/0891-5849(94)90201-1" @default.
- W2060264695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8070689" @default.
- W2060264695 hasPublicationYear "1994" @default.
- W2060264695 type Work @default.
- W2060264695 sameAs 2060264695 @default.
- W2060264695 citedByCount "16" @default.
- W2060264695 countsByYear W20602646952018 @default.
- W2060264695 countsByYear W20602646952019 @default.
- W2060264695 crossrefType "journal-article" @default.
- W2060264695 hasAuthorship W2060264695A5020670999 @default.
- W2060264695 hasAuthorship W2060264695A5054700319 @default.
- W2060264695 hasAuthorship W2060264695A5073021091 @default.
- W2060264695 hasConcept C126322002 @default.
- W2060264695 hasConcept C134018914 @default.
- W2060264695 hasConcept C181199279 @default.
- W2060264695 hasConcept C185592680 @default.
- W2060264695 hasConcept C2775838275 @default.
- W2060264695 hasConcept C2776151105 @default.
- W2060264695 hasConcept C2776992346 @default.
- W2060264695 hasConcept C2778102346 @default.
- W2060264695 hasConcept C2778514916 @default.
- W2060264695 hasConcept C2778979269 @default.
- W2060264695 hasConcept C2779470414 @default.
- W2060264695 hasConcept C2779961880 @default.
- W2060264695 hasConcept C513476851 @default.
- W2060264695 hasConcept C55493867 @default.
- W2060264695 hasConcept C71924100 @default.
- W2060264695 hasConcept C86803240 @default.
- W2060264695 hasConceptScore W2060264695C126322002 @default.
- W2060264695 hasConceptScore W2060264695C134018914 @default.
- W2060264695 hasConceptScore W2060264695C181199279 @default.
- W2060264695 hasConceptScore W2060264695C185592680 @default.
- W2060264695 hasConceptScore W2060264695C2775838275 @default.
- W2060264695 hasConceptScore W2060264695C2776151105 @default.
- W2060264695 hasConceptScore W2060264695C2776992346 @default.
- W2060264695 hasConceptScore W2060264695C2778102346 @default.
- W2060264695 hasConceptScore W2060264695C2778514916 @default.
- W2060264695 hasConceptScore W2060264695C2778979269 @default.
- W2060264695 hasConceptScore W2060264695C2779470414 @default.
- W2060264695 hasConceptScore W2060264695C2779961880 @default.
- W2060264695 hasConceptScore W2060264695C513476851 @default.
- W2060264695 hasConceptScore W2060264695C55493867 @default.
- W2060264695 hasConceptScore W2060264695C71924100 @default.
- W2060264695 hasConceptScore W2060264695C86803240 @default.
- W2060264695 hasIssue "6" @default.
- W2060264695 hasLocation W20602646951 @default.
- W2060264695 hasLocation W20602646952 @default.
- W2060264695 hasOpenAccess W2060264695 @default.
- W2060264695 hasPrimaryLocation W20602646951 @default.
- W2060264695 hasRelatedWork W1534586762 @default.
- W2060264695 hasRelatedWork W1992809759 @default.
- W2060264695 hasRelatedWork W2020128704 @default.
- W2060264695 hasRelatedWork W2048336513 @default.
- W2060264695 hasRelatedWork W2076298828 @default.
- W2060264695 hasRelatedWork W2182283556 @default.
- W2060264695 hasRelatedWork W2275412511 @default.
- W2060264695 hasRelatedWork W2336230294 @default.
- W2060264695 hasRelatedWork W2374558055 @default.
- W2060264695 hasRelatedWork W2400265273 @default.
- W2060264695 hasVolume "16" @default.
- W2060264695 isParatext "false" @default.
- W2060264695 isRetracted "false" @default.
- W2060264695 magId "2060264695" @default.
- W2060264695 workType "article" @default.