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- W2060291260 abstract "Azole and carbodithioate hybrids were synthesized as alkyl 1H-azole-1-carbodithioates (7-27) and evaluated for spermicidal/microbicidal activities against human sperm, Trichomonas vaginalis and Candida species. Seventeen compounds (7-14, 16-18 and 20-25) showed spermicidal activity at MEC 1.0% (w/v) and permanently immobilized 100% normal human spermatozoa within ∼30 s. Seventeen compounds (7-11, 13-18 and 20-25) exhibited anti-Candida activity (IC50 1.26-47.69 μg/mL). All compounds were devoid of bactericidal activity against four bacterial strains (50.00 μg/mL) and antiprotozoal activity against Trichomonas vaginalis (200.00 μg/mL). Four promising compounds (10, 17, 20 and 22) have better safety profile as compared to Nonoxynol-9 (N-9). Docking study was done to visualize the possible interaction of designed scaffold with prospective receptor (Cyp51) of Candida albicans." @default.
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- W2060291260 date "2013-12-01" @default.
- W2060291260 modified "2023-09-25" @default.
- W2060291260 title "Azole–carbodithioate hybrids as vaginal anti-Candida contraceptive agents: Design, synthesis and docking studies" @default.
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- W2060291260 doi "https://doi.org/10.1016/j.ejmech.2013.09.007" @default.
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