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• W2060295116 abstract "Sustained activation of AMPA and kainate receptors in rat oligodendrocytes induces cytosolic calcium overload, mitochondrial depolarization, and an increase of reactive oxygen species, resulting in cell death. Here, we provide evidence that Bax, a proapoptotic member of the Bcl-2 protein family, is involved in excitotoxic apoptotic death of oligodendrocytes and that calpain mediates Bax activation. Cultured Bax(-/-) oligodendrocytes, obtained from the optic nerve of Bax knock-out mice, were resistant to AMPA and kainate receptor-mediated insults. In turn, both mitochondrial calcium uptake and mitochondrial alterations after excitotoxic insults were diminished in Bax-null oligodendrocytes. Moreover, pretreatment with furosemide, a blocker of Bax translocation to mitochondria, significantly protected rat and mouse oligodendrocytes from AMPA- and kainate-induced damage; in contrast, bongkrekic acid, a blocker of the mitochondrial permeability transition pore, had no effect. Finally, we analyzed the participation of calpain, which cleaves Bax and is activated by AMPA and kainate, in oligodendrocyte death. Pretreatment with 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD150606), a broad cell-permeable calpain inhibitor, and two additional calpain inhibitors diminished Bax activation, inhibited its translocation to mitochondria, and attenuated all apoptotic events resulting from excitotoxic insults to rat oligodendrocytes. Together, these results indicate that Bax and calpain are essential intermediaries of the mitochondria-dependent death pathway, triggered by AMPA and kainate receptor activation in oligodendrocytes." @default.
• W2060295116 created "2016-06-24" @default.
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• W2060295116 date "2011-02-23" @default.
• W2060295116 modified "2023-10-18" @default.
• W2060295116 title "Bax and Calpain Mediate Excitotoxic Oligodendrocyte Death Induced by Activation of Both AMPA and Kainate Receptors" @default.
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• W2060295116 cites W1522813904 @default.
• W2060295116 cites W1528634994 @default.
• W2060295116 cites W1560820741 @default.
• W2060295116 cites W1564601025 @default.
• W2060295116 cites W1607777232 @default.
• W2060295116 cites W1621337337 @default.
• W2060295116 cites W1638297412 @default.
• W2060295116 cites W1745634660 @default.
• W2060295116 cites W1963564407 @default.
• W2060295116 cites W1966734999 @default.
• W2060295116 cites W1970374401 @default.
• W2060295116 cites W1972673753 @default.
• W2060295116 cites W1981254140 @default.
• W2060295116 cites W1984156662 @default.
• W2060295116 cites W1985235409 @default.
• W2060295116 cites W1995874521 @default.
• W2060295116 cites W1997168663 @default.
• W2060295116 cites W2002091021 @default.
• W2060295116 cites W2007604900 @default.
• W2060295116 cites W2012076962 @default.
• W2060295116 cites W2014586657 @default.
• W2060295116 cites W2014999693 @default.
• W2060295116 cites W2016133409 @default.
• W2060295116 cites W2022889787 @default.
• W2060295116 cites W2030339393 @default.
• W2060295116 cites W2032279605 @default.
• W2060295116 cites W2033873142 @default.
• W2060295116 cites W2036734843 @default.
• W2060295116 cites W2036822121 @default.
• W2060295116 cites W2038436096 @default.
• W2060295116 cites W2047418898 @default.
• W2060295116 cites W2049359499 @default.
• W2060295116 cites W2049421129 @default.
• W2060295116 cites W2053440290 @default.
• W2060295116 cites W2057112578 @default.
• W2060295116 cites W2060184827 @default.
• W2060295116 cites W2060344069 @default.
• W2060295116 cites W2060457554 @default.
• W2060295116 cites W2062793260 @default.
• W2060295116 cites W2063663247 @default.
• W2060295116 cites W2063815034 @default.
• W2060295116 cites W2064011682 @default.
• W2060295116 cites W2064598952 @default.
• W2060295116 cites W2064621260 @default.
• W2060295116 cites W2068739854 @default.
• W2060295116 cites W2073706613 @default.
• W2060295116 cites W2077834260 @default.
• W2060295116 cites W2081560586 @default.
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• W2060295116 cites W2087877138 @default.
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• W2060295116 cites W2092590573 @default.
• W2060295116 cites W2093166812 @default.
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• W2060295116 cites W2103615857 @default.
• W2060295116 cites W2114001234 @default.
• W2060295116 cites W2117115489 @default.
• W2060295116 cites W2139081467 @default.
• W2060295116 cites W2141260882 @default.
• W2060295116 cites W2144139389 @default.
• W2060295116 cites W2145509877 @default.
• W2060295116 cites W2146060811 @default.
• W2060295116 cites W2149313534 @default.
• W2060295116 cites W2150315067 @default.
• W2060295116 cites W2159117404 @default.
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• W2060295116 cites W2167860852 @default.
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• W2060295116 doi "https://doi.org/10.1523/jneurosci.5578-10.2011" @default.
• W2060295116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6623763" @default.
• W2060295116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21414921" @default.
• W2060295116 hasPublicationYear "2011" @default.
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