FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060299210> ?p ?o ?g. }

• W2060299210 endingPage "2059" @default.
• W2060299210 startingPage "2053" @default.
• W2060299210 abstract "The present studies examined the temporal sequence of inducible nitric oxide synthase (iNOS) gene expression and the cellular sources of iNOS protein and of 3-nitrotyrosine, as a marker of production of nitric oxide-derived reactive nitrogen intermediates during murine multi-stage carcinogenesis. Levels of iNOS mRNA in dorsal skin isolated from acetone-treated female Sencar mice were 2.5-fold higher than iNOS gene expression detected in cutaneous tissue isolated from Sencar mice at 1, 3, 6, 10, 16 and 22 weeks after exposure to a single topical application of 25 nmol 7,12-dimethylbenz[a]anthracene (DMBA) followed by repetitive applications of 2 microgram 17-O-tetradecanoylphorbol-13-acetate (TPA). Papillomas isolated at 16 and 22 weeks of a tumor promotion protocol also had low levels of iNOS mRNA. The diminished levels of iNOS mRNA inversely correlated with the extent of TPA-induced epidermal hyperplasia. In acetone-treated mouse skin, iNOS immunospecific antibody binding was localized to the stratum corneum and suprabasal keratinocytes. In contrast, iNOS protein was present in lower amounts and was localized to the upper-most suprabasal keratinocytes in cutaneous tissue isolated at 22 weeks following a single exposure to either 25 nmol DMBA or acetone and repetitive applications of 2 microgram TPA. At all time points examined over the 22 week time period of papilloma growth, infiltrating neutrophils within the dermis bound significant levels of anti-iNOS antibodies. The production of iNOS by neutrophils within the dermis correlated with the formation of protein nitrotyrosination within the dermal tissue, as detected by 3-nitrotyrosine-specific antibodies. The present studies indicate that NOS and reactive nitrogen intermediates, including peroxynitrite, are produced specifically by dermal neutrophils during the tumor promotion process at time points that correspond to simultaneous production of reactive oxygen intermediates. Conversely, iNOS is simultaneously down-regulated in hyperplastic epidermis and in papillomas." @default.
• W2060299210 created "2016-06-24" @default.
• W2060299210 creator A5007549562 @default.
• W2060299210 creator A5014740424 @default.
• W2060299210 creator A5018747376 @default.
• W2060299210 creator A5044032694 @default.
• W2060299210 creator A5084870740 @default.
• W2060299210 date "1996-09-01" @default.
• W2060299210 modified "2023-09-23" @default.
• W2060299210 title "Gene expression and cellular sources of inducible nitric oxide synthase during tumor promotion" @default.
• W2060299210 cites W1484882395 @default.
• W2060299210 cites W1488616816 @default.
• W2060299210 cites W1563668204 @default.
• W2060299210 cites W1564354136 @default.
• W2060299210 cites W1653031648 @default.
• W2060299210 cites W1664175075 @default.
• W2060299210 cites W180529491 @default.
• W2060299210 cites W1834041853 @default.
• W2060299210 cites W1929009802 @default.
• W2060299210 cites W1950662099 @default.
• W2060299210 cites W1967245379 @default.
• W2060299210 cites W1969192989 @default.
• W2060299210 cites W1978038466 @default.
• W2060299210 cites W1979230311 @default.
• W2060299210 cites W1979780797 @default.
• W2060299210 cites W1983039463 @default.
• W2060299210 cites W1984775666 @default.
• W2060299210 cites W1984997174 @default.
• W2060299210 cites W1990134662 @default.
• W2060299210 cites W1991000309 @default.
• W2060299210 cites W1992390260 @default.
• W2060299210 cites W1994303699 @default.
• W2060299210 cites W1999589434 @default.
• W2060299210 cites W2012100682 @default.
• W2060299210 cites W2015803272 @default.
• W2060299210 cites W2020638356 @default.
• W2060299210 cites W2023170094 @default.
• W2060299210 cites W2023670376 @default.
• W2060299210 cites W2024191096 @default.
• W2060299210 cites W2038208478 @default.
• W2060299210 cites W2038443620 @default.
• W2060299210 cites W2042196624 @default.
• W2060299210 cites W2042763203 @default.
• W2060299210 cites W2043285825 @default.
• W2060299210 cites W2047724809 @default.
• W2060299210 cites W2055354965 @default.
• W2060299210 cites W2061303270 @default.
• W2060299210 cites W2063419502 @default.
• W2060299210 cites W2067338751 @default.
• W2060299210 cites W2067577602 @default.
• W2060299210 cites W2076279613 @default.
• W2060299210 cites W2080950878 @default.
• W2060299210 cites W2082654358 @default.
• W2060299210 cites W2092126340 @default.
• W2060299210 cites W2093344987 @default.
• W2060299210 cites W2099048452 @default.
• W2060299210 cites W2099213973 @default.
• W2060299210 cites W2103517120 @default.
• W2060299210 cites W2104740411 @default.
• W2060299210 cites W2124922337 @default.
• W2060299210 cites W2140220133 @default.
• W2060299210 cites W2140365442 @default.
• W2060299210 cites W2159795301 @default.
• W2060299210 cites W2162455056 @default.
• W2060299210 cites W2313326603 @default.
• W2060299210 cites W2343387207 @default.
• W2060299210 cites W2398767988 @default.
• W2060299210 cites W596724494 @default.
• W2060299210 cites W89326209 @default.
• W2060299210 cites W2911737113 @default.
• W2060299210 doi "https://doi.org/10.1093/carcin/17.9.2053" @default.
• W2060299210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8824534" @default.
• W2060299210 hasPublicationYear "1996" @default.
• W2060299210 type Work @default.
• W2060299210 sameAs 2060299210 @default.
• W2060299210 citedByCount "48" @default.
• W2060299210 countsByYear W20602992102014 @default.
• W2060299210 countsByYear W20602992102016 @default.
• W2060299210 countsByYear W20602992102020 @default.
• W2060299210 countsByYear W20602992102023 @default.
• W2060299210 crossrefType "journal-article" @default.
• W2060299210 hasAuthorship W2060299210A5007549562 @default.
• W2060299210 hasAuthorship W2060299210A5014740424 @default.
• W2060299210 hasAuthorship W2060299210A5018747376 @default.
• W2060299210 hasAuthorship W2060299210A5044032694 @default.
• W2060299210 hasAuthorship W2060299210A5084870740 @default.
• W2060299210 hasConcept C104317684 @default.
• W2060299210 hasConcept C105702510 @default.
• W2060299210 hasConcept C134018914 @default.
• W2060299210 hasConcept C150194340 @default.
• W2060299210 hasConcept C153911025 @default.
• W2060299210 hasConcept C181199279 @default.
• W2060299210 hasConcept C185592680 @default.
• W2060299210 hasConcept C195794163 @default.
• W2060299210 hasConcept C2777168633 @default.
• W2060299210 hasConcept C2777622882 @default.
• W2060299210 hasConcept C2777624698 @default.
• W2060299210 hasConcept C2778326061 @default.

• next