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- W2060306388 abstract "Diabetes mellitus (DM) is a chronic metabolic disease characterized by the presence of hyperglycemia, which can lead to many complications over time. These complications, such as nephropathy, retinopathy, neuropathy, impaired wound healing and accelerated atherosclerosis, are implicated with a large number of cellular and subcellular changes on vessels. In agreement, evidence indicates that in retinopathy, nephropathy and atherosclerotic plaque, there is excessive angiogenesis, whereas in wound healing and myocardial perfusion, blood vessel growth is impaired. Despite the awareness of this angiogenic paradox, many questions remain unanswered. This review aims at highlighting the different microvascular and macrovascular complications that are often concurrent in diabetic patients. A revision of the recent findings published in the literature regarding the angiogenic paradox will be performed. Apparently, endothelial dysfunction, as well as molecules such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF) play a major role in diabetic vascular complications. Specific tissues with impaired angiogenesis exhibit microenvironment features, such as increased PAI-1/uPA ratio and decreased blood flow, whereas TGFbeta increases extracellular matrix deposition, preventing the vascularization process. In addition, the monocytes/macrophages are important in endothelium activation for arteriogenesis and its arteriogenic response is reduced, leading to impaired collateral artery growth. Moreover, molecular mechanisms involved will be addressed, including abnormalities in growth factor, cytokines and metabolic derangements." @default.
- W2060306388 created "2016-06-24" @default.
- W2060306388 creator A5028767906 @default.
- W2060306388 creator A5075332287 @default.
- W2060306388 date "2013-06-01" @default.
- W2060306388 modified "2023-10-17" @default.
- W2060306388 title "Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox" @default.
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- W2060306388 cites W154322005 @default.
- W2060306388 cites W1598235393 @default.
- W2060306388 cites W1763493018 @default.
- W2060306388 cites W1973411883 @default.
- W2060306388 cites W1973465872 @default.
- W2060306388 cites W1978282413 @default.
- W2060306388 cites W1980101105 @default.
- W2060306388 cites W1980837668 @default.
- W2060306388 cites W1984870157 @default.
- W2060306388 cites W1989159761 @default.
- W2060306388 cites W1998409162 @default.
- W2060306388 cites W2000322711 @default.
- W2060306388 cites W2003433134 @default.
- W2060306388 cites W2006931635 @default.
- W2060306388 cites W2012825701 @default.
- W2060306388 cites W2013260905 @default.
- W2060306388 cites W2016901718 @default.
- W2060306388 cites W2018008610 @default.
- W2060306388 cites W2019182002 @default.
- W2060306388 cites W2020267609 @default.
- W2060306388 cites W2021358426 @default.
- W2060306388 cites W2030537668 @default.
- W2060306388 cites W2030593202 @default.
- W2060306388 cites W2030631420 @default.
- W2060306388 cites W2030790832 @default.
- W2060306388 cites W2037344875 @default.
- W2060306388 cites W2041857857 @default.
- W2060306388 cites W2042046596 @default.
- W2060306388 cites W2045481776 @default.
- W2060306388 cites W2046741338 @default.
- W2060306388 cites W2047094134 @default.
- W2060306388 cites W2053609923 @default.
- W2060306388 cites W2054393454 @default.
- W2060306388 cites W2054569982 @default.
- W2060306388 cites W2061631515 @default.
- W2060306388 cites W2066469770 @default.
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- W2060306388 cites W2067701598 @default.
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- W2060306388 cites W2079617745 @default.
- W2060306388 cites W2080143715 @default.
- W2060306388 cites W2083922350 @default.
- W2060306388 cites W2084048949 @default.
- W2060306388 cites W2086067512 @default.
- W2060306388 cites W2086812462 @default.
- W2060306388 cites W2092537058 @default.
- W2060306388 cites W2100425244 @default.
- W2060306388 cites W2113531489 @default.
- W2060306388 cites W2114234975 @default.
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- W2060306388 cites W2124736173 @default.
- W2060306388 cites W2126713892 @default.
- W2060306388 cites W2134467550 @default.
- W2060306388 cites W2140908019 @default.
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- W2060306388 cites W2152068191 @default.
- W2060306388 cites W2155998401 @default.
- W2060306388 cites W2159932650 @default.
- W2060306388 cites W2163926528 @default.
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- W2060306388 doi "https://doi.org/10.1016/j.lfs.2013.04.001" @default.
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