FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060319604> ?p ?o ?g. }

• W2060319604 endingPage "209" @default.
• W2060319604 startingPage "201" @default.
• W2060319604 abstract "Cherubism (OMIM#118400) is a genetic disorder in children characterized by excessive jawbone destruction with proliferation of fibro-osseous lesions containing a large number of osteoclasts. Mutations in the SH3-domain binding protein 2 (SH3BP2) are responsible for cherubism. Analysis of the knock-in (KI) mouse model of cherubism showed that homozygous cherubism mice (Sh3bp2KI/KI) spontaneously develop systemic autoinflammation and inflammatory bone loss and that cherubism is a TNF-α-dependent hematopoietic disorder. In this study, we investigated whether bone marrow transplantation (BMT) is effective for the treatment of inflammation and bone loss in Sh3bp2KI/KI mice. Bone marrow (BM) cells from wild-type (Sh3bp2+/+) mice were transplanted to 6-week-old Sh3bp2KI/KI mice with developing inflammation and to 10-week-old Sh3bp2KI/KI mice with established inflammation. Six-week-old Sh3bp2KI/KI mice transplanted with Sh3bp2+/+ BM cells exhibited improved body weight loss, facial swelling, and survival rate. Inflammatory lesions in the liver and lung as well as bone loss in calvaria and mandibula were ameliorated at 10 weeks after BMT compared to Sh3bp2KI/KI mice transplanted with Sh3bp2KI/KI BM cells. Elevation of serum TNF-α levels was not detected after BMT. BMT was effective for up to 20 weeks in 6-week-old Sh3bp2KI/KI mice transplanted with Sh3bp2+/+ BM cells. BMT also ameliorated the inflammation and bone loss in 10-week-old Sh3bp2KI/KI mice. Thus our study demonstrates that BMT improves the inflammation and bone loss in cherubism mice. BMT may be effective for the treatment of cherubism patients." @default.
• W2060319604 created "2016-06-24" @default.
• W2060319604 creator A5008308268 @default.
• W2060319604 creator A5011044077 @default.
• W2060319604 creator A5015646777 @default.
• W2060319604 creator A5030695626 @default.
• W2060319604 creator A5068152432 @default.
• W2060319604 creator A5072734104 @default.
• W2060319604 date "2015-02-01" @default.
• W2060319604 modified "2023-09-26" @default.
• W2060319604 title "Bone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism mice" @default.
• W2060319604 cites W1274344746 @default.
• W2060319604 cites W1489733444 @default.
• W2060319604 cites W1544569979 @default.
• W2060319604 cites W1579111286 @default.
• W2060319604 cites W1593734057 @default.
• W2060319604 cites W1602280846 @default.
• W2060319604 cites W1785649545 @default.
• W2060319604 cites W1964536733 @default.
• W2060319604 cites W1967406643 @default.
• W2060319604 cites W1972471049 @default.
• W2060319604 cites W1979054122 @default.
• W2060319604 cites W1982402871 @default.
• W2060319604 cites W1986153051 @default.
• W2060319604 cites W1993218448 @default.
• W2060319604 cites W1995500501 @default.
• W2060319604 cites W1997353354 @default.
• W2060319604 cites W1997851205 @default.
• W2060319604 cites W2003171404 @default.
• W2060319604 cites W2010777991 @default.
• W2060319604 cites W2012290736 @default.
• W2060319604 cites W2015027277 @default.
• W2060319604 cites W2018827685 @default.
• W2060319604 cites W2019520088 @default.
• W2060319604 cites W2019576909 @default.
• W2060319604 cites W2027799335 @default.
• W2060319604 cites W2032602780 @default.
• W2060319604 cites W2040621454 @default.
• W2060319604 cites W2043636512 @default.
• W2060319604 cites W2052605694 @default.
• W2060319604 cites W2052898605 @default.
• W2060319604 cites W2053419680 @default.
• W2060319604 cites W2054243858 @default.
• W2060319604 cites W2060496255 @default.
• W2060319604 cites W2062941136 @default.
• W2060319604 cites W2066749771 @default.
• W2060319604 cites W2074477988 @default.
• W2060319604 cites W2074963908 @default.
• W2060319604 cites W2076191063 @default.
• W2060319604 cites W2076246571 @default.
• W2060319604 cites W2076630716 @default.
• W2060319604 cites W2080907365 @default.
• W2060319604 cites W2088816616 @default.
• W2060319604 cites W2098854099 @default.
• W2060319604 cites W2108088303 @default.
• W2060319604 cites W2108749719 @default.
• W2060319604 cites W2122387317 @default.
• W2060319604 cites W2125987139 @default.
• W2060319604 cites W2127403047 @default.
• W2060319604 cites W2135791851 @default.
• W2060319604 cites W2137271664 @default.
• W2060319604 cites W2137884823 @default.
• W2060319604 cites W2146932786 @default.
• W2060319604 cites W2148607491 @default.
• W2060319604 cites W2148872227 @default.
• W2060319604 cites W2149898137 @default.
• W2060319604 cites W2156176482 @default.
• W2060319604 cites W2159823307 @default.
• W2060319604 cites W2167798404 @default.
• W2060319604 cites W2169051446 @default.
• W2060319604 cites W2299378181 @default.
• W2060319604 cites W2324840046 @default.
• W2060319604 cites W2396330878 @default.
• W2060319604 cites W977069352 @default.
• W2060319604 doi "https://doi.org/10.1016/j.bone.2014.10.021" @default.
• W2060319604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4274253" @default.
• W2060319604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25445458" @default.
• W2060319604 hasPublicationYear "2015" @default.
• W2060319604 type Work @default.
• W2060319604 sameAs 2060319604 @default.
• W2060319604 citedByCount "9" @default.
• W2060319604 countsByYear W20603196042015 @default.
• W2060319604 countsByYear W20603196042016 @default.
• W2060319604 countsByYear W20603196042017 @default.
• W2060319604 countsByYear W20603196042018 @default.
• W2060319604 countsByYear W20603196042019 @default.
• W2060319604 crossrefType "journal-article" @default.
• W2060319604 hasAuthorship W2060319604A5008308268 @default.
• W2060319604 hasAuthorship W2060319604A5011044077 @default.
• W2060319604 hasAuthorship W2060319604A5015646777 @default.
• W2060319604 hasAuthorship W2060319604A5030695626 @default.
• W2060319604 hasAuthorship W2060319604A5068152432 @default.
• W2060319604 hasAuthorship W2060319604A5072734104 @default.
• W2060319604 hasBestOaLocation W20603196042 @default.
• W2060319604 hasConcept C109159458 @default.
• W2060319604 hasConcept C126322002 @default.
• W2060319604 hasConcept C142724271 @default.
• W2060319604 hasConcept C202751555 @default.

• next