FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060323836> ?p ?o ?g. }

• W2060323836 endingPage "1054" @default.
• W2060323836 startingPage "1049" @default.
• W2060323836 abstract "S‐1 is an oral anticancer agent composed of tegafur (FT), 5‐chloro‐2,4‐dihydroxypyridine (CDHP), and potassium oxonate. CDHP is added to prevent degradation of 5‐fluorouracil (5‐FU) by inhibiting dihydropyrimidine dehydrogenase. CYP2A6 is involved in the biotransformation of FT to 5‐FU. Thus, we prospectively analyzed the effects of the CYP2A6 genotype, plasma level of CDHP, and patient characteristics on the pharmacokinetic (PK) variability of FT and 5‐FU. Fifty‐four Japanese patients with metastatic or recurrent cancers who received S‐1 were enrolled. The CYP2A6 polymorphisms (* 4A , * 7 , and * 9 ) with deficient or reduced activity were analyzed. All subjects were classified into three groups according to their CYP2A6 genotype: wild type (* 1/ * 1 ), one‐variant allele (* 1/any ), or two‐variant alleles (combination other than * 1 ). The PK of FT, 5‐FU, and CDHP were measured on day 1 of treatment. Multivariate regression analysis revealed that oral clearance of FT was associated with the CYP2A6 genotype (analysis of variance [ANOVA], P = 0.000838). The oral clearance of FT seen in patients with the two‐variant alleles was significantly lower than those in wild type and the one‐variant allele (95% confidence intervals 0.75–2.41 and 0.41–1.82, respectively; Tukey‐Kramer test). The area under the time–concentration curve (AUC) of 5‐FU was significantly correlated with the AUC of CDHP (ANOVA, P = 0.00126). The AUC of 5‐FU and CDHP were inversely correlated with creatinine clearance (ANOVA, P = 0.0164 and P = 0.000762, respectively). Although the CYP2A6 variants are the cause of the PK variability of FT, the AUC of CDHP affected by renal function is the key determinant of the variability in the PK of 5‐FU. ( Cancer Sci 2008; 99: 1049–1054)" @default.
• W2060323836 created "2016-06-24" @default.
• W2060323836 creator A5008014743 @default.
• W2060323836 creator A5013994958 @default.
• W2060323836 creator A5018753888 @default.
• W2060323836 creator A5019102133 @default.
• W2060323836 creator A5021070991 @default.
• W2060323836 creator A5025014729 @default.
• W2060323836 creator A5032933683 @default.
• W2060323836 creator A5034993620 @default.
• W2060323836 creator A5036329937 @default.
• W2060323836 creator A5048964506 @default.
• W2060323836 creator A5050623654 @default.
• W2060323836 creator A5052440202 @default.
• W2060323836 creator A5057518286 @default.
• W2060323836 creator A5066324189 @default.
• W2060323836 creator A5076349434 @default.
• W2060323836 creator A5079533730 @default.
• W2060323836 creator A5085463021 @default.
• W2060323836 creator A5086225100 @default.
• W2060323836 date "2008-04-01" @default.
• W2060323836 modified "2023-10-15" @default.
• W2060323836 title "CYP2A6 and the plasma level of 5-chloro-2, 4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1" @default.
• W2060323836 cites W1508983572 @default.
• W2060323836 cites W1968636004 @default.
• W2060323836 cites W1968703649 @default.
• W2060323836 cites W1969574631 @default.
• W2060323836 cites W1974957356 @default.
• W2060323836 cites W1977837291 @default.
• W2060323836 cites W1987502189 @default.
• W2060323836 cites W2009787497 @default.
• W2060323836 cites W2015658785 @default.
• W2060323836 cites W2019980810 @default.
• W2060323836 cites W2032540605 @default.
• W2060323836 cites W2057785324 @default.
• W2060323836 cites W2073131930 @default.
• W2060323836 cites W2078292625 @default.
• W2060323836 cites W2100021150 @default.
• W2060323836 cites W2112163451 @default.
• W2060323836 cites W2122226579 @default.
• W2060323836 cites W2129271383 @default.
• W2060323836 cites W2152256906 @default.
• W2060323836 cites W2162517914 @default.
• W2060323836 cites W2208638853 @default.
• W2060323836 cites W2229238935 @default.
• W2060323836 cites W2282703690 @default.
• W2060323836 doi "https://doi.org/10.1111/j.1349-7006.2008.00773.x" @default.
• W2060323836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18380793" @default.
• W2060323836 hasPublicationYear "2008" @default.
• W2060323836 type Work @default.
• W2060323836 sameAs 2060323836 @default.
• W2060323836 citedByCount "53" @default.
• W2060323836 countsByYear W20603238362012 @default.
• W2060323836 countsByYear W20603238362013 @default.
• W2060323836 countsByYear W20603238362014 @default.
• W2060323836 countsByYear W20603238362015 @default.
• W2060323836 countsByYear W20603238362016 @default.
• W2060323836 countsByYear W20603238362017 @default.
• W2060323836 countsByYear W20603238362018 @default.
• W2060323836 countsByYear W20603238362019 @default.
• W2060323836 countsByYear W20603238362020 @default.
• W2060323836 countsByYear W20603238362021 @default.
• W2060323836 countsByYear W20603238362022 @default.
• W2060323836 crossrefType "journal-article" @default.
• W2060323836 hasAuthorship W2060323836A5008014743 @default.
• W2060323836 hasAuthorship W2060323836A5013994958 @default.
• W2060323836 hasAuthorship W2060323836A5018753888 @default.
• W2060323836 hasAuthorship W2060323836A5019102133 @default.
• W2060323836 hasAuthorship W2060323836A5021070991 @default.
• W2060323836 hasAuthorship W2060323836A5025014729 @default.
• W2060323836 hasAuthorship W2060323836A5032933683 @default.
• W2060323836 hasAuthorship W2060323836A5034993620 @default.
• W2060323836 hasAuthorship W2060323836A5036329937 @default.
• W2060323836 hasAuthorship W2060323836A5048964506 @default.
• W2060323836 hasAuthorship W2060323836A5050623654 @default.
• W2060323836 hasAuthorship W2060323836A5052440202 @default.
• W2060323836 hasAuthorship W2060323836A5057518286 @default.
• W2060323836 hasAuthorship W2060323836A5066324189 @default.
• W2060323836 hasAuthorship W2060323836A5076349434 @default.
• W2060323836 hasAuthorship W2060323836A5079533730 @default.
• W2060323836 hasAuthorship W2060323836A5085463021 @default.
• W2060323836 hasAuthorship W2060323836A5086225100 @default.
• W2060323836 hasConcept C104317684 @default.
• W2060323836 hasConcept C112705442 @default.
• W2060323836 hasConcept C121608353 @default.
• W2060323836 hasConcept C123321153 @default.
• W2060323836 hasConcept C126322002 @default.
• W2060323836 hasConcept C135763542 @default.
• W2060323836 hasConcept C185592680 @default.
• W2060323836 hasConcept C196013638 @default.
• W2060323836 hasConcept C2777299880 @default.
• W2060323836 hasConcept C2778050828 @default.
• W2060323836 hasConcept C2780456651 @default.
• W2060323836 hasConcept C526171541 @default.
• W2060323836 hasConcept C55493867 @default.
• W2060323836 hasConcept C62231903 @default.
• W2060323836 hasConcept C71924100 @default.
• W2060323836 hasConcept C86745063 @default.

• next